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Recombinant Human MAPKAPK2 Protein, MYC/DDK-tagged

Cat.No. : MAPKAPK2-550H
Product Overview : Recombinant human MAPKAPK2 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 45.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : mitogen-activated protein kinase-activated protein kinase 2[ Homo sapiens ]
Official Symbol : MAPKAPK2
Synonyms : MAPKAP-K2; MK-2; MK2
Gene ID : 9261
mRNA Refseq : NM_004759.4
Protein Refseq : NP_004750.1
MIM : 602006
UniProt ID : P49137

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What structural features of MAPKAPK2 are critical for its kinase activity, and how do these features influence its interactions with substrates and regulatory partners? 05/11/2022

MAPKAPK2's kinase activity is influenced by its structural features, including the catalytic domain. These features determine substrate interactions and regulatory partnerships, providing insights into its molecular functions.

What is known about the role of MAPKAPK2 in the immune response, particularly in the regulation of cytokine production and immune cell functions? 06/29/2020

MAPKAPK2 plays a role in the immune response by regulating cytokine production and immune cell functions. It influences the activity of transcription factors involved in immune-related gene expression.

How does MAPKAPK2 contribute to cellular motility, and what molecular mechanisms are involved in its regulation of the cytoskeleton and cell migration? 12/17/2019

MAPKAPK2 regulates cellular motility by influencing the cytoskeleton and cell migration. It phosphorylates proteins involved in cytoskeletal dynamics, impacting cell motility and invasive behavior.

Can you elaborate on the regulatory mechanisms controlling MAPKAPK2 activation and its substrate specificity? 01/15/2019

MAPKAPK2 activation is regulated by p38 MAP kinase through phosphorylation. Its substrate specificity is determined by specific phosphorylation motifs, and its activity is influenced by interacting proteins.

In cancer research, how is MAPKAPK2 implicated in tumor development and progression, and are there potential therapeutic strategies targeting this kinase? 04/18/2018

MAPKAPK2 has been associated with tumor development and progression. Understanding its role in cancer biology may lead to the development of targeted therapies, although challenges exist in achieving specificity.

Customer Reviews (3)

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04/15/2022

    The lab product sets a new standard for quality. Delivery was speedy, and the customer service team was exceptionally helpful.

    11/23/2020

      Reliable product, friendly customer service, and efficient delivery.

      08/06/2019

        Precision in quality, responsive customer service, and fast, secure delivery

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