Recombinant Human MAPKAPK2
Cat.No. : | MAPKAPK2-27128TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 46-end of Human MAPKAP Kinase 2, expressed by baculovirus in Sf9 insect cells, with an N-terminal tag, MW 68 kDa. |
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Description : | This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. |
Tissue specificity : | Expressed in all tissues examined. |
Biological activity : | Specific activity: 254 nmol/min/mg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Contains 1 protein kinase domain. |
Tag : | Non |
Gene Name : | MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 [ Homo sapiens ] |
Official Symbol : | MAPKAPK2 |
Synonyms : | MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MAP kinase-activated protein kinase 2; |
Gene ID : | 9261 |
mRNA Refseq : | NM_004759 |
Protein Refseq : | NP_004750 |
MIM : | 602006 |
Uniprot ID : | P49137 |
Chromosome Location : | 1q32 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CREB phosphorylation, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem; |
Function : | ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
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MAPKAPK2-5356M | Recombinant Mouse MAPKAPK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPKAPK2-1366H | Recombinant Human MAPKAPK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPKAPK2-1227H | Recombinant Human MAPKAPK2 Protein (H47-R364, ΔH217-P237, S216G), Tag Free | +Inquiry |
MAPKAPK2-1228H | Recombinant Human MAPKAPK2 Protein (H47-R364, ΔH217-P237, S216G), His tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe lab product sets a new standard for quality. Delivery was speedy, and the customer service team was exceptionally helpful.
Reliable product, friendly customer service, and efficient delivery.
Precision in quality, responsive customer service, and fast, secure delivery
Q&As (5)
Ask a questionMAPKAPK2's kinase activity is influenced by its structural features, including the catalytic domain. These features determine substrate interactions and regulatory partnerships, providing insights into its molecular functions.
MAPKAPK2 plays a role in the immune response by regulating cytokine production and immune cell functions. It influences the activity of transcription factors involved in immune-related gene expression.
MAPKAPK2 regulates cellular motility by influencing the cytoskeleton and cell migration. It phosphorylates proteins involved in cytoskeletal dynamics, impacting cell motility and invasive behavior.
MAPKAPK2 activation is regulated by p38 MAP kinase through phosphorylation. Its substrate specificity is determined by specific phosphorylation motifs, and its activity is influenced by interacting proteins.
MAPKAPK2 has been associated with tumor development and progression. Understanding its role in cancer biology may lead to the development of targeted therapies, although challenges exist in achieving specificity.
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