mchr1
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  • Official Full Name
  • melanin-concentrating hormone receptor 1
  • Background
  • The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
  • Synonyms
  • MCHR1; melanin-concentrating hormone receptor 1; G protein coupled receptor 24 , GPR24; MCH1R; SLC1; SLC-1; MCH-1R; MCH receptor 1; G protein-coupled receptor 24; somatostatin receptor-like protein; GPR24; MGC32129
Cat.#:MCHR1-5224HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MCHR1 Protein, GST-tagged
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Cat.#:MCHR1-778HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MCHR1, GST-tagged
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Cat.#:MCHR1-3617RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MCHR1 Protein
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Cat.#:MCHR1-2700RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MCHR1 Protein, His-tagged
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Cat.#:MCHR1-4424HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MCHR1 293 Cell Lysate
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Cat.#:Kit-1386Tag:N/A
Source (Host):Species:
Product nameMCHR1 U2OS β-Arrestin GPCR Assay Kit
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Cat.#:Kit-1387Tag:N/A
Source (Host):Species:
Product nameMCHR1 Total GPCR Internalization Assay Kit
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Cat.#:Kit-1388Tag:N/A
Source (Host):Species:
Product namecAMP MCHR1 CHO-K1 GPCR Assay Kit
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Cat.#:Kit-1041Tag:N/A
Source (Host):Species:
Product nameATP Colorimetric/Fluorometric Assay Kit
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Involved Pathway

MCHR1 involved in several pathways and played different roles in them. We selected most pathways MCHR1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCHR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
PRLR; OPRD1A; OPRM1; GABRA2; P2RY4; GABRA6; MLNR; GRIN2A; ADRB2B; TACR2

Protein Function

MCHR1 has several biochemical functions, for example, G-protein coupled receptor activity, melanin-concentrating hormone receptor activity, neuropeptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCHR1 itself. We selected most functions MCHR1 had, and list some proteins which have the same functions with MCHR1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein OR13A1; OLFR494; S1PR5B; GPR20; PARAPINOPSINB; OR51D1; MRGPRX2; TAS2R138; FZD9; VMN1R54
Function melanin-concentrating hormone receptor activity
Related Protein MCHR1
Function neuropeptide receptor activity
Related Protein HCRTR2; NPBWR2; SORCS1; PRLHR; NPFFR1L3; NMUR1; NPFFR2; NPFFR1L2; HCRTR1; MCHR1
Function receptor binding
Related Protein SELPLG; TNFSF9; CCL15; P2RX4; NSG1; ANGPTL1; MATK; CD2; FGF12A; SMARCD1

MCHR1 Related Articles

Philippe, C; Haeusler, D; et al. Comparative autoradiographic in vitro investigation of melanin concentrating hormone receptor 1 ligands in the central nervous system. EUROPEAN JOURNAL OF PHARMACOLOGY 735:177-183(2014).
Kroon, MW; Kemp, EH; et al. Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 27:1172-1175(2013).