med4
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  • Official Full Name
  • mediator complex subunit 4
  • Background
  • This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms
  • MED4; mediator complex subunit 4; mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae) , VDRIP, vitamin D receptor interacting protein; mediator of RNA polymerase II transcription subunit 4; DRIP36; HSPC126; TRAP36; Activator-recruited cofactor 36 kDa component; ARC36; FLJ10956; MED4_HUMAN; Mediator of RNA polymerase II transcription, subunit 4 homolog; OTTHUMP00000018390; OTTHUMP00000018391; OTTHUMP00000018392; RP11-90M2.2; TRAP/SMCC/PC2 subunit p36 subunit; VDRIP; Vitamin D3 receptor-interacting protein complex 36 kDa component
Cat.#:MED4-4467HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED4 Protein, GST-tagged
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Cat.#:MED4-2406HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mediator Complex Subunit 4, His-tagged
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Cat.#:MED4-29557THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED4, His-tagged
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Cat.#:MED4-30188THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED4, His-tagged
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Cat.#:MED4-9704MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED4 Protein
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Cat.#:MED4-3639RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MED4 Protein
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Cat.#:MED4-2727RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MED4 Protein, His-tagged
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Cat.#:MED4-2604ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED4
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Cat.#:MED4-4381HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MED4 293 Cell Lysate
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Involved Pathway

MED4 involved in several pathways and played different roles in them. We selected most pathways MED4 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway
PLCG2; PIK3R5; PDPK1; STAT1; BMP4; RCAN1; PLCB4; ESR1; PRKACB; SRC

Protein Function

MED4 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED4 itself. We selected most functions MED4 had, and list some proteins which have the same functions with MED4. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription cofactor activity
Related Protein MED15; MED18; MED13A; MED17; MED24; MED10; NKX2; MED30; MED14; MED9
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein ZCCHC18; ACTN1; NCOA2; PUS1; ACTN4; RBM14; PRKCBB; PPARGC1B; PKN1; NCOA1
Function protein binding
Related Protein PLXNB2; MID1IP1; GJA1; ATP6V1C2; MED24; MEF2A; KIRREL3; CCDC43; ATP2A2; EGR2
Function receptor activity
Related Protein RAMP3; CADM4; CNTNAP1; MED13; P2RY2; EPHB6; APLNR; CSF2RA; LDLR; Pla2r1
Function thyroid hormone receptor binding
Related Protein GAS2L1; NR0B2; MED1; HMGN3; GTF2B; FUS; TRIP6; TAF11; MED12; ZNHIT3
Function transcription cofactor activity
Related Protein RFXANK; ZNF763; ZFP865; MAP3K7; ELK4; MED1; ZNF212; MSX2; LDB1A; MED24
Function vitamin D receptor binding
Related Protein MED24; TAF7; MED17; TAF11; MED30; SNW1; RUNX2B; RXRA; MED16; MED14

Interacting Protein

MED4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED4.
MED10; MED9; MED19; MED26

MED4 Related Articles

Gomez-Garcia, MR; Serrano, A; et al. Expression studies of two paralogous ppa genes encoding distinct Family I pyrophosphatases in marine unicellular cyanobacteria reveal inactivation of the typical cyanobacterial gene. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295:890-897(2002).
Garczarek, L; van der Staay, GWM; et al. Isolation and characterization of photosystem I from two strains of the marine oxychlorobacterium Prochlorococcus. PHOTOSYNTHESIS RESEARCH 56:131-141(1998).
Partensky, F; LaRoche, J; et al. The divinyl-chlorophyll a/b-protein complexes of two strains of the oxyphototrophic marine prokaryote Prochlorococcus - Characterization and response to changes in growth irradiance. PHOTOSYNTHESIS RESEARCH 51:209-222(1997).