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MLF1

Official Full Name

myeloid leukemia factor 1
Overview

This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

MLF1; myeloid leukemia factor 1; myeloid leukemia factor 1 variant 1; myeloid leukemia factor 1 variant 2; myeloid leukemia factor 1 variant 3; Hls7; MLF1_HUMAN; Myelodysplasia myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1; OTTHUMP00000213453; OTTHUMP00000213454; OTTHUMP00000213483; OTTHUMP00000213484; OTTHUMP00000213485; OTTHUMP00000213486; OTTHUMP00000213487; OTTHUMP00000213488; OTTHUMP00000213492; OTTHUMP00000213493; OTTHUMP00000213494;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
T7

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MLF1-3438H	Recombinant Human MLF1 protein, His-tagged	E.coli	His		Inquiry
Human	MLF1-2390H	Recombinant Human MLF1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MLF1-2944H	Recombinant Human Myeloid Leukemia Factor 1, T7-tagged	E.coli	T7		Inquiry
Human	MLF1-149H	Recombinant Human MLF1 protein, T7-tagged	E.coli	T7		Inquiry
Human	MLF1-29154TH	Recombinant Human MLF1, T7 -tagged	E.coli	T7		Inquiry
Human	MLF1-4297HCL	Recombinant Human MLF1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MLF1-643HF	Recombinant Full Length Human MLF1 Protein, GST-tagged	In Vitro Cell Free System	GST	268 amino acids	Inquiry
Human	MLF1-3229H	Recombinant Human MLF1 protein, GST-tagged	E.coli	GST	1-268aa	Inquiry
Rhesus Macaque	MLF1-2780R	Recombinant Rhesus monkey MLF1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MLF1-2601R	Recombinant Rhesus Macaque MLF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MLF1-2601R-B	Recombinant Rhesus Macaque MLF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

MLF1 involved in several pathways and played different roles in them. We selected most pathways MLF1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	Bcl2a1b;SS18;BCL2A1;HPGD;HIST1H3H;MMP3;HIST1H3A;Aff1;FCGR1A

MLF1 has several biochemical functions, for example, DNA binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLF1 itself. We selected most functions MLF1 had, and list some proteins which have the same functions with MLF1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	MCM8;HOXC10A;THOC1;MIER1A;RPS15;ZNF292A;SIM1B;ASCL1B;CREBZF
protein binding	HOXD12;IGFBP3;CP110;LRCH4;EIF4E;PLEKHA2;PHIP;KRIT1;HYAL3
protein domain specific binding	PLG;MPP5;TH;HOMER2;TBL1X;YWHABA;VAPA;CA;YWHAQ

MLF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLF1.

DNAJB6; YWHAE; a8k1f4_human; a8k251_human; b2rc52_human; b4de84_human; HAX1; IRS4; GNB5; TET3; PSMD3; ZBED4; REC8; BAG2; BAG3; MOS