msh2
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  • Official Full Name
  • mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
  • Background
  • The MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma,While germline MSH2 mutations are responsible for approximately 50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids.
  • Synonyms
  • MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); COCA1, mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1); DNA mismatch repair protein Msh2; HNPCC; HNPCC1; hMSH2; FCC1; COCA1; LCFS2
Cat.#:MSH2-162HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSH2
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Cat.#:MSH2-28175THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MSH2 protein, GST-tagged
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Cat.#:MSH2-28793THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MSH2
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Cat.#:MSH2-493HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MSH2 protein, MYC/DDK-tagged
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Cat.#:MSH2-621HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MSH2 Protein, His&GST-tagged
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Cat.#:MSH2-10131MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MSH2 Protein
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Cat.#:MSH2-3787RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MSH2 Protein
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Cat.#:MSH2-12683ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MSH2
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Cat.#:MSH2-4120HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MSH2 293 Cell Lysate
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Involved Pathway

MSH2 involved in several pathways and played different roles in them. We selected most pathways MSH2 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mismatch repair
RPA2; POLD1; SSBP1; POLD4; EXO1; RFC1; MSH3; POLD2; MSH2; PCNA
Pathways in cancer
Ar; CCDC6; GNG4; WNT5B; FZD9; DAPK3; PTK2; SFPI1; PTGER2; PTGS2
Colorectal cancer
PIK3R2; APPL1; ARAF; MSH6; APC; TP53; FOS; CASP9; MAP2K1; MAPK1

Protein Function

MSH2 has several biochemical functions, for example, contributes_to ADP binding, contributes_to ATP binding, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH2 itself. We selected most functions MSH2 had, and list some proteins which have the same functions with MSH2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to ADP binding
Related Protein MSH6; MSH2; ATP5D
Function contributes_to ATP binding
Related Protein ATP1A2; SFRP5; MSH6; ATP1B1; ATP5D; MSH2; ABCG8
Function contributes_to ATPase activity
Related Protein MSH6; ATP5B; ABCG8; SFRP5; RFC3; RUVBL2; ATP1B1; ATP5D; ATP5E; ATP1A2
Function DNA binding
Related Protein WDHD1; ILF3B; ATF4; PHC2; TBX5A; NKX2-6; ZFP451; ZNF565; UBTFL1; POU5F1
Function DNA-dependent ATPase activity
Related Protein RAD51D; IGHMBP2; CDK7; RAD51C; DDX11; MSH4; SMARCA4; RAD51L3; CHD8; CHD6
Function contributes_to MutLalpha complex binding
Related Protein MSH6; MSH2
Function Y-form DNA binding
Related Protein WRN; RAD18; MSH3; MEN1; MSH2
Function centromeric DNA binding
Related Protein CENPB; MSH2; MLH3; CENPC1; ZW10; KIF2C; MSH3
Function contributes_to dinucleotide insertion or deletion binding
Related Protein MSH3; MSH2
Function contributes_to dinucleotide repeat insertion binding
Related Protein MSH2; MSH3
Function double-strand/single-strand DNA junction binding
Related Protein MSH3; MSH2
Function contributes_to double-stranded DNA binding
Related Protein MSH6; APITD1; MSH2; STRA13
Function enzyme binding
Related Protein ATXN10; MDM2; GSTM3; HIST1H2AN; NOP14; KRT79; LAMB1; AKT1; MARCH6; CYP1A1
Function contributes_to four-way junction DNA binding
Related Protein XRCC3; MSH6; RAD51L3; RAD51L1; MSH2; RAD51D; XRCC2; RAD51C; RAD51B
Function contributes_to guanine/thymine mispair binding
Related Protein MSH2; MSH6
Function guanine/thymine mispair binding
Related Protein MSH2
Function heteroduplex DNA loop binding
Related Protein MSH3; MSH2
Function contributes_to magnesium ion binding
Related Protein MSH2; MSH6
Function contributes_to mismatched DNA binding
Related Protein MSH3; MSH2; MSH6
Function contributes_to oxidized purine DNA binding
Related Protein MSH6; MSH2
Function protein C-terminus binding
Related Protein HESX1; PEX10; DGKZ; KCNIP3; BLOC1S2A; TJP2; AGO2; VGLL1; SREBF2; SLC4A1
Function protein binding
Related Protein USP14; HBZ; ADRB2; CCNB1; GPATCH4; POLA1; FRMPD1; SYTL2; RSAD2; ATF6
Function contributes_to protein binding
Related Protein TAF10; INHA; POLR2A; MEF2A; CRY1A; MSH6; CPSF3L; ACVR2A; MLH1; INTS10
Function protein homodimerization activity
Related Protein OLIG2; CHMP4C; BMP4; GSTM3; MITD1; TFAP4; CTBP2A; LGALS6; DMRTC1C2; GRM6
Function protein kinase binding
Related Protein BCL10; TRAF3; DVL1; CALM1; NEK9; CEP152; CYLD; THY1; CAV2; PAK2
Function contributes_to single guanine insertion binding
Related Protein MSH3; MSH6; MSH2
Function contributes_to single thymine insertion binding
Related Protein MSH6; MSH2
Function contributes_to single-stranded DNA binding
Related Protein PMS2; MLH1; MSH2; IGHM; POLR2D; IGJ; MSH3

Interacting Protein

MSH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH2.
MSH6; SLX4; EXO1; E2F3; BRCA1

MSH2 Related Articles

Stark, AM; Doukas, A; et al. Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. NEUROLOGICAL RESEARCH 37:95-105(2015).
Jentzsch, T; Robl, B; et al. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma. ANTICANCER RESEARCH 34:6961-6972(2014).