mtor
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  • Official Full Name
  • mechanistic target of rapamycin (serine/threonine kinase)
  • Background
  • The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
  • Synonyms
  • MTOR; mechanistic target of rapamycin (serine/threonine kinase); FRAP; FRAP1; FRAP2; RAFT1; RAPT1; serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1;
Cat.#:MTOR-5728HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MTOR Protein, GST-tagged
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Cat.#:MTOR-156HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MTOR, MYC/DDK-tagged
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Cat.#:MTOR-1820HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTOR protein, His & T7-tagged
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Cat.#:MTOR-30254THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MTOR
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Cat.#:MTOR-42HTag:Flag|His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MTOR/RPTOR/MLST8 protein, FLAG/His-tagged
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Cat.#:MTOR-523HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MTOR
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Cat.#:MTOR-10215MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MTOR Protein
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Cat.#:Mtor-25MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mtor protein, His-tagged
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Cat.#:MTOR-3815RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MTOR Protein
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Cat.#:MTOR-4634ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MTOR
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Cat.#:MTOR-4068HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MTOR 293 Cell Lysate
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Involved Pathway

MTOR involved in several pathways and played different roles in them. We selected most pathways MTOR participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PLCG1; PLCG2; RPS6KB1; PRKCB; MAP2K2; PAK3; NCK2; PAK2B; BADB; MAP2K4A
HIF- signaling pathway
PFKFB3; CAMK2D; TIMP1; ENO2; HK2; EIF4E1B; NPPA; RPS6KB2; HKDC1; LDHA
Phospholipase D signaling pathway
AKT2; MAP2K2; PIK3CB; MTOR; PDGFRB; RAF1; GRB2; PLA2G4F; INS1; CYTH1
mTOR signaling pathway
EIF4BA; PTENB; PRKCA; PTEN; HIF1AB; EIF4E1C; RPS6KA3B; PIK3CD; EIF4E2RS1; CAB39
PIK-Akt signaling pathway
FGF2; PDPK1; LAMB1; IFNA14; GNG5; GRB2; NRAS; CD19; FOXO3; F2R
AMPK signaling pathway
CREB3L4; MLYCD; PIK3R2; CPT1A; RPS6KB2; PPP2CA; IRS4; LEP; SCD; IGF1R
Jak-STAT signaling pathway
IL20RA; GHRA; PTPN11; IL-15RA; CCND2; CNTF; GH2; IL5; MYCB; Ifna15
Insulin signaling pathway
RAF1B; INPP5K; TSC1A; TSC2; PPP1R3A; SH2B2; EIF4E2; TRIP10; RPS6KB1; SOCS3B
Thyroid hormone signaling pathway
ESR1; DIO1; CCND1; KRAS; MTOR; NCOR1; MED14; PLCZ1; NOTCH3; CASP9
Adipocytokine signaling pathway
IKBKB; RXRBA; PRKAB1A; PTPN11A; POMC; PRKAB1; G6PCA.2; PRKAA2; SLC2A4; IRS1
Type II diabetes mellitus
IRS2; TNF; MAPK3; IRS1; PRKCZ; PIK3R3; SOCS2; HK3; SOCS3; PRKCD
Insulin resistance
INSRB; PRKAA2; PPARGC1A; PIK3R5; PPP1R3CB; TBC1D4; G6PC; SREBF1; GFPT2; TNFRSF1A
Pathways in cancer
FN1; NKX3; TCF7L2; F2R; PML; GNG11; PTGER4; IKBKB; LAMC2; FGF14
Proteoglycans in cancer
ACTG1; PRKCB; FLNC; WNT9B; RPS6KB1; WNT7B; CTTN; CBL; CD44; WNT4
MicroRNAs in cancer
MDM2; FSCN1; ERBB2; NRAS; HMOX1; TNXB; DNMT3B; TNR; SPRY2; DICER1
Glioma
TGFA; KRAS; MAP2K2; MDM2; AKT1; PIK3R1; PIK3CA; SOS1; CALML3; CCND1
Prostate cancer
MAP2K2; Pdgfa&Pdgfb; PIK3R1; NDRG1; PIK3CG; TCF7L2; CASP9; IGF1R; MDM2; INS
Acute myeloid leukemia
ZBTB16; RELA; PIK3CB; MAP2K1; CCNA1; LEF1; FLT3; HRAS; PIK3CD; BRAF
Central carbon metabolism in cancer
PIK3CA; HRAS; PIK3R3; PDGFRB; SLC1A5; C12orf5; PKM; NTRK3; PGAM1; PIK3CD
Choline metabolism in cancer
WASF2; PIP5K1B; MTOR; SLC44A2; SLC22A2; HIF1A; EIF4EBP1; LYPLA1; DGKQ; PCYT1A

Protein Function

MTOR has several biochemical functions, for example, ATP binding, RNA polymerase III type 1 promoter DNA binding, RNA polymerase III type 2 promoter DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTOR itself. We selected most functions MTOR had, and list some proteins which have the same functions with MTOR. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NLRX1; SMARCA4; CAMKK2; PDK1; KARS; UBA6; MMAB; CSNK2A2; PIP5K1A; FGFR1A
Function RNA polymerase III type 1 promoter DNA binding
Related Protein RPTOR; MAF1; MTOR
Function RNA polymerase III type 2 promoter DNA binding
Related Protein MTOR; RPTOR; MAF1
Function RNA polymerase III type 3 promoter DNA binding
Related Protein MTOR; RPTOR; MAF1
Function TFIIIC-class transcription factor binding
Related Protein MTOR; RPTOR
Function drug binding
Related Protein PPARG; CHRNB3; HMGCS1; FOLR1; CHRNA7; MT2A; HTR2A; CHRNB4; TYMS; TLR7
Function kinase activity
Related Protein ROCK2B; DYRK1AA; BMPR1BA; PRKRIRA; BMPR1BB; PRPS2; PRKD3; DCLK1A; NLK1; BMPR1AA
Function phosphoprotein binding
Related Protein LYN; PIH1D1; THRAP3; RRAGA; PKD2; ARR3; YWHAB; DPYS; MS4A2; FKBP4
Function protein binding
Related Protein SKAP2; FAM153C; IL1R1; COG2; ETV6; TMX3; ZNF490; URM1; SERPINB5; ACOT8
Function protein dimerization activity
Related Protein EBF3A; ATOH1A; SCXA; ASCL2; ZBED4; ARNTL1B; PEX3; MXD4; MYCH; MXD1
Function protein domain specific binding
Related Protein GABRR1; CASP2; ERCC1; VRK2; YWHAG; MTOR; OCLN; HMGB2; IL1B; TRIM11
Function protein serine/threonine kinase activity
Related Protein NEK10; TLK1B; GRK1B; RPS6KB2; SMOK3B; STK4; WNK1; PRKCBB; TNK2; CPNE3
Function ribosome binding
Related Protein ABCF1; CPEB3; ETF1; EIF5A; SEC61B; CPEB4; MTRF1L; BAG6; SBDS; WIBG

Interacting Protein

MTOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTOR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTOR.
RPTOR

MTOR Related Articles

Knuth, A; Liu, L; et al. Placenta Growth Factor Induces Invasion and Activates p70 during Rapamycin Treatment in Trophoblast Cells. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 73:330-340(2015).
Gargalionis, AN; Korkolopoulou, P; et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. INTERNATIONAL JOURNAL OF CANCER 136:1515-1527(2015).