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MYOT

  • Official Full Name

    myotilin

  • Overview

    This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[provided by RefSeq, Oct 2008]
  • Synonyms

    MYOT; myotilin; MFM3; TTID; TTOD; LGMD1; LGMD1A; 57 kDa cytoskeletal protein; myofibrillar titin-like Ig domains protein; titin immunoglobulin domain protein (myotilin);

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYOT-4003HCL Recombinant Human MYOT 293 Cell Lysate HEK293 N/A
Human MYOT-556H Recombinant Human MYOT protein, GST-tagged E. coli GST 191-498 aa
Human MYOT-2496H Recombinant Human MYOT Protein, His-tagged E.coli His
Human MYOT-6616HF Recombinant Full Length Human MYOT Protein, GST-tagged In Vitro Cell Free System GST 498 amino acids
Human MYOT-5856H Recombinant Human MYOT Protein, GST-tagged Wheat Germ GST
Mouse Myot-1811M Recombinant Mouse Myot Protein, His-tagged E.coli N-His Arg6-Leu188
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MYOT Related Articles

MYOT involved in several pathways and played different roles in them. We selected most pathways MYOT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYOT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MYOT has several biochemical functions, for example, actin binding, alpha-actinin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYOT itself. We selected most functions MYOT had, and list some proteins which have the same functions with MYOT. You can find most of the proteins on our site.

Function Related Protein
actin bindingFLNC;MYO15;MYHC4;MYH13;PPP1R18;CNN3;MYBPC2;TBCCD1;CFL1
alpha-actinin bindingKCNN2;PPARG;ALMS1;MAGI1;ADORA2A;KCNA5;RARA;DAG1;XIRP2
protein bindingC8orf4;CLCNKB;LIMD1;AKAP9;COMMD1;PGR;BICC1;FASTKD5;LSM3
structural constituent of muscleMYBPC3;TPM2;ASPH;SMTN;OBSCN;SORBS2;ACTN2;JPH1;TPM4

MYOT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYOT here. Most of them are supplied by our site. Hope this information will be useful for your research of MYOT.

FLNC; NME7; AXIN1; PDLIM3; TFG; GPRASP2; DOCK9; LRP12

Kim, JY; Jeong, EH; et al. Myofibrillar Myooathy - A Case Report -. KOREAN JOURNAL OF PATHOLOGY 44:426-430(2010).
Sanger, JW; Wang, JS; et al. Myofibrillogenesis in Skeletal Muscle Cells in Zebrafish. CELL MOTILITY AND THE CYTOSKELETON 66:556-566(2009).
  • Q&As
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