myot
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  • Official Full Name
  • myotilin
  • Background
  • This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[provided by RefSeq, Oct 2008]
  • Synonyms
  • MYOT; myotilin; MFM3; TTID; TTOD; LGMD1; LGMD1A; 57 kDa cytoskeletal protein; myofibrillar titin-like Ig domains protein; titin immunoglobulin domain protein (myotilin);
Cat.#:MYOT-2496HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYOT Protein, His-tagged
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Cat.#:MYOT-5856HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYOT Protein, GST-tagged
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Cat.#:MYOT-4003HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYOT 293 Cell Lysate
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Protein Function

MYOT has several biochemical functions, for example, actin binding, alpha-actinin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYOT itself. We selected most functions MYOT had, and list some proteins which have the same functions with MYOT. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein SSH1; DMD; HOOK1; PIP; ABLIM3; SPTBN2; C19orf21; INPPL1A; CAPZA1B; SPATA31
Function alpha-actinin binding
Related Protein KCNA5; ADORA2A; LRRC10; RARA; PKD2L1; PPARG; ALMS1; KCNN2; XIRP2; MYOT
Function protein binding
Related Protein AOC3; MTERF; TMEM106B; BAI3; PLSCR3; FAM109A; CDC26; CCK; CNIH2; LTA4H
Function structural constituent of muscle
Related Protein MYLPF; DMD; NEXN; JPH1; PLEC; MYL6; NEBL; MYBPC2; MYBPH; MYH11

Interacting Protein

MYOT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYOT here. Most of them are supplied by our site. Hope this information will be useful for your research of MYOT.
FLNC; NME7; AXIN1; PDLIM3; TFG; GPRASP2; DOCK9; LRP12

MYOT Related Articles

Kim, JY; Jeong, EH; et al. Myofibrillar Myooathy - A Case Report -. KOREAN JOURNAL OF PATHOLOGY 44:426-430(2010).
Sanger, JW; Wang, JS; et al. Myofibrillogenesis in Skeletal Muscle Cells in Zebrafish. CELL MOTILITY AND THE CYTOSKELETON 66:556-566(2009).