nat1
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  • Official Full Name
  • N-acetyltransferase 1 (arylamine N-acetyltransferase)
  • Background
  • This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NAT1; N-acetyltransferase 1 (arylamine N-acetyltransferase); AAC1; arylamine N-acetyltransferase 1; ARY1_HUMAN; Arylamide acetylase 1; Arylamine N acetyltransferase 1; MNAT; Monomorphic arylamine N acetyltransferase; Monomorphic arylamine N-acetyltransferase; N acetyltransferase type 1; N-acetyltransferase type 1; NAT 1; NAT-1; NATI; OTTHUMP00000122488; OTTHUMP00000224577; OTTHUMP00000224578; OTTHUMP00000224579
Cat.#:NAT1-3573HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NAT1, His-tagged
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Cat.#:Nat1-405MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nat1 Protein, His-tagged
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Cat.#:NAT1-138HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NAT1 Protein, His-tagged
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Cat.#:NAT1-28863THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NAT1
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Cat.#:NAT1-30282THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NAT1, His-tagged
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Cat.#:NAT1-30283THTag:Fc
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NAT1, Fc-tagged
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Cat.#:NAT1-10434MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NAT1 Protein
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Cat.#:Nat1-3653MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Nat1, His-tagged
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Cat.#:NAT1-3906RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NAT1 Protein
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Cat.#:NAT1-1168HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NAT1 cell lysate
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Involved Pathway

NAT1 involved in several pathways and played different roles in them. We selected most pathways NAT1 participated on our site, such as Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Caffeine metabolism
NAT; UOX; CYP2A6; NAT1; Nat3; CYP1A2; NAT2; PNAT10; PNAT3; XDH
Drug metabolism - other enzymes
UGT2B7; UMPS; HPRT1; NAT; UGT1A4; CES1; UGT1A6; UGT2A2; CES1C; UGT1AB
Metabolic pathways
DLAT; HAL; CHSY3; ALG2; DAO.1; PLD4; NDUFB2; Ckmm; CHSY1; OCRL
Chemical carcinogenesis
GSTM1; CYP1A1; ARNT; HSD11B1; ADH4; ADH1A; CYP3A5; SULT1A1; CYP2E1; GSTA5

Protein Function

NAT1 has several biochemical functions, for example, ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT1 itself. We selected most functions NAT1 had, and list some proteins which have the same functions with NAT1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DHX30; GUCY2E; XRCC6; BCR; TOR2A; FLJ11011L; FBXO18; NME6; CKMT2B; IGF1R
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein MAK; CDK16; CDKL2; CDK5R1; CDK9; CDKL5; CDKL4; CDK6; CDK13; ICK
Function protein kinase activity
Related Protein MAPKAPK2; EIF2AK3; PRKAG1; IKBKB; STK17B; PRKD2; KSR1; PKMYT1; PKDCCA; MAP2K2B

Interacting Protein

NAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT1.
LRRK2

NAT1 Related Articles

Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).
Mikuls, TR; LeVan, T; et al. Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. ARTHRITIS AND RHEUMATISM 64:655-664(2012).