nek6
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  • Official Full Name
  • NIMA (never in mitosis gene a)-related expressed kinase 6
  • Background
  • The Aspergillus nidulans never in mitosis A (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform f
  • Synonyms
  • NEK6; NIMA (never in mitosis gene a)-related expressed kinase 6; serine/threonine-protein kinase Nek6; Highly similar to cell cycle protein kinase CDC5/MSD2; NEK6_HUMAN; Never in mitosis A-related kinase 6; NIMA (Never In Mitosis Gene A) Related Kinase 6; NimA related protein kinase 6; NimA-related protein kinase 6; Protein kinase SID6 1512; Protein kinase SID6-1512; Putative serine threonine protein kinase; Serine/threonine protein kinase Nek6; SID6 1512; SID61512; NIMA-related expressed kinase 6; 1300007C09Rik
Cat.#:NEK6-28258THTag:His
Source (Host):Species:Human
Product nameRecombinant Human NEK6, His-tagged
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Cat.#:NEK6-29622THTag:
Source (Host):Species:Human
Product nameRecombinant Human NEK6
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Cat.#:NEK6-662HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEK6, Active
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Cat.#:NEK6-1905CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NEK6
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Cat.#:NEK6-559HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NEK6, His-tagged
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Cat.#:NEK6-370HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NEK6, GST-tagged, Active
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Cat.#:NEK6-3877HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NEK6 293 Cell Lysate
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Involved Pathway

NEK6 involved in several pathways and played different roles in them. We selected most pathways NEK6 participated on our site, such as Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of NIMA Kinases NEK9, NEK6, NEK7
NEK9; NEK6; NEK7
Cell Cycle
BUB1; ACD; MIS18BP1; CP110; ANAPC7; CEP152; TMEM188; EP300; SYCP2; KIF18A
Cell Cycle, Mitotic
SPC25; CSNK2A2; MCPH1; RCC2; POLD3; KNTC1; KIF2A; USO1; NDEL1A; ERCC6L
M Phase
CENPL; MCPH1; ENSA; CENPK; PHF8; SKA2; ARPP19; KIF2B; BLZF1; NCAPD2
Mitotic Prophase
SETB; ARPP19B; ARPP19A; DULLARD; NEK7; NEK6; MASTL; TMEM188; VRK2; PHF8
Nuclear Envelope Breakdown
NEK6; CNEP1R1; NEK7; DULLARD; CTDNEP1; NEK9; CTDNEP1B; CTDNEP1A; TMEM188
Nuclear Pore Complex (NPC) Disassembly
NEK6; NEK9; NEK7

Protein Function

NEK6 has several biochemical functions, for example, ATP binding, kinesin binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK6 itself. We selected most functions NEK6 had, and list some proteins which have the same functions with NEK6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NME6; BUB1B; LIG3; PAK6; NAIP1; UBE2N; DDX39; MAPK8A; ATP1A1B; CLCN6
Function kinesin binding
Related Protein ATCAY; SPAG9; KIF18B; NUP62; CLSTN1; KIAA1279; JAKMIP1; KLC3; NEFH; DISC1
Function magnesium ion binding
Related Protein BPNT1; TESC; PGM2; MARK1; PPM1AB; NLK; PDXK; NT5C1B; IDH3G; SRPK1
Function protein binding
Related Protein ZIC3; SLC25A6; SLMAP; UGGT2; FAM161A; ADAM9; MYOCD; WTIP; TMEM242; VARS2
Function protein kinase binding
Related Protein ZBTB4; NR4A3; RAB11FIP2; ZFP36; PTPRR; SMAD1; SREBF1; ITGB2; CCNL1; GATA4
Function protein serine/threonine kinase activity
Related Protein PHKG1B; ICK; IRAK3; CDK1; SMOK3A; PINK1; TSSK4; STK24; SPEG; TP53RK
Function signal transducer activity
Related Protein IKBKG; PLCD1; GRM6B; PTK2B; TAS2R120; MADD; TAAR9; TICAM2; PTH1RA; VMN1R45

Interacting Protein

NEK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK6.
NECAB2; TRIM27; TCF4; TRIM23; XIAP; TNK2; AES