nek6
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  • Official Full Name
  • NIMA (never in mitosis gene a)-related expressed kinase 6
  • Background
  • The Aspergillus nidulans never in mitosis A (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform f
  • Synonyms
  • NEK6; NIMA (never in mitosis gene a)-related expressed kinase 6; serine/threonine-protein kinase Nek6; Highly similar to cell cycle protein kinase CDC5/MSD2; NEK6_HUMAN; Never in mitosis A-related kinase 6; NIMA (Never In Mitosis Gene A) Related Kinase 6; NimA related protein kinase 6; NimA-related protein kinase 6; Protein kinase SID6 1512; Protein kinase SID6-1512; Putative serine threonine protein kinase; Serine/threonine protein kinase Nek6; SID6 1512; SID61512; NIMA-related expressed kinase 6; 1300007C09Rik
Cat.#:NEK6-28258THTag:His
Source (Host):Species:Human
Product nameRecombinant Human NEK6, His-tagged
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Cat.#:NEK6-29622THTag:
Source (Host):Species:Human
Product nameRecombinant Human NEK6
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Cat.#:NEK6-662HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEK6, Active
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Cat.#:NEK6-1905CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NEK6
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Cat.#:NEK6-559HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NEK6, His-tagged
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Cat.#:NEK6-370HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NEK6, GST-tagged, Active
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Cat.#:NEK6-3877HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NEK6 293 Cell Lysate
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Involved Pathway

NEK6 involved in several pathways and played different roles in them. We selected most pathways NEK6 participated on our site, such as Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of NIMA Kinases NEK9, NEK6, NEK7
NEK7; NEK9; NEK6
Cell Cycle
CDKN1C; CDC25A; MSH5; CCNB1; CTDNEP1A; CENPI; POT1; RAD50; GOLGA2; TOP2A
Cell Cycle, Mitotic
NEK6; SMC4; NUMA1; NUP50; ODF2B; CLASP1A; HIST4H4; GINS1; CSNK2B; CENPO
M Phase
B9D2; NSL1; KIF2A; NUF2; GOLGA2; KIF18A; ARPP19A; ZW10; CENPP; MCPH1
Mitotic Prophase
TMEM188; NEK6; SETA; VRK2; ENSAA; DULLARD; CTDNEP1B; CTDNEP1A; ARPP19A; ARPP19
Nuclear Envelope Breakdown
CTDNEP1B; TMEM188; NEK6; NEK9; NEK7; CTDNEP1A; DULLARD; CTDNEP1; CNEP1R1
Nuclear Pore Complex (NPC) Disassembly
NEK6; NEK7; NEK9

Protein Function

NEK6 has several biochemical functions, for example, ATP binding, kinesin binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK6 itself. We selected most functions NEK6 had, and list some proteins which have the same functions with NEK6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TDRD9; TOP2B; HSPA9; SHPK; DYNC1LI2; TAOK2; TTLL12; PRKY; LMTK2; KIF16B
Function kinesin binding
Related Protein NEK6; DISC1; KIF18B; KIFAP3A; AP1G1; KLC2; KCNC1; KIFAP3B; ARPC2; NEFH
Function magnesium ion binding
Related Protein CDC42BPG; AASDHPPT; TDP2; GTPBP5; ATP9A; RPS6KA2; PSPH; HMGCL; RPS6KA3A; IDH2
Function protein binding
Related Protein TTC6; SMARCA5; COIL; ARHGEF12; TFAP2A; IL4; HELZ2; VPS33B; FSCN1; VPS18
Function protein kinase binding
Related Protein AP1B1; ADRA2A; SHC4; CDK5; FER; CADPS; TRIB3; IRS2; PDGFRB; ELP2
Function protein serine/threonine kinase activity
Related Protein PRKCI; DYRK1A; RPS6KA3A; CSNK2A2; Aatk; ROCK2A; CDC42BPB; TLK1B; RAF1; DAPK2
Function signal transducer activity
Related Protein PTK2AA; LSP1; TAS2R126; CC2D1A; MIER1; LPAR6; TAAR14D; GNG8; TAAR1B; DKKL1

Interacting Protein

NEK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK6.
NECAB2; TRIM27; TCF4; TRIM23; XIAP; TNK2; AES