npy
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  • Official Full Name
  • neuropeptide Y
  • Background
  • Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that acts as a neurotransmitter in the brain and in the autonomic nervous system of humans; slight variations of the peptide are found in many other animals. In the autonomic system it is mainly produced by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue. In the brain it is produced in various locations including the hypothalamus, and is thought to have several functions, including: increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure and controlling epileptic seizures.
  • Synonyms
  • PYY4; pro-neuropeptide Y
Cat.#:NPY-1267HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPY Protein, His-tagged
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Cat.#:NPY-6052HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NPY Protein, GST-tagged
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Cat.#:NPY-1350HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPY, GST-tagged
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Cat.#:NPY-233HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human NPY protein, His-tagged
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Cat.#:NPY-262HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NPY Protein, Fc-tagged
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Cat.#:NPY-29247THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NPY
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Cat.#:NPY-29655THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NPY
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Cat.#:Npy-7870RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Npy protein, His & GST-tagged
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Cat.#:NPY-3086RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NPY Protein, His-tagged
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Cat.#:NPY-7022CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NPY
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Cat.#:NPY-8700ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NPY
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Cat.#:NPY-3726HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NPY 293 Cell Lysate
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Involved Pathway

NPY involved in several pathways and played different roles in them. We selected most pathways NPY participated on our site, such as cAMP signaling pathway, Adipocytokine signaling pathway, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
HHIP; RRAS; DRD1A; FSHR; PPP1CA; ATP1A4; HCN4; GRIN1; PPP1CC; GRIN2C
Adipocytokine signaling pathway
PRKAB2; NFKBIE; RXRGB; CPT1B; IKBKG; RXRGA; ACSL3A; JAK2A; IRS1; LEPB
Regulation of lipolysis in adipocytes
IRS4; IRS1; NPY1R; GNAI2; AQP7; LIPE; PIK3CA; INS; PIK3CD; GNAI3
Alcoholism
H3F3B; GRIN2D; HIST1H2BO; H2AFJ; GNG11; HDAC7A; NRAS; HIST1H3C; CREB3L1; GM14477

Protein Function

NPY has several biochemical functions, for example, G-protein coupled receptor activity, calcium channel regulator activity, neuropeptide Y receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPY itself. We selected most functions NPY had, and list some proteins which have the same functions with NPY. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein TAS2R134; S1PR4; LPAR5B; MRGPRX2; OR12D3; GPR132; OR5K1; GPR143; PTH1RB; OR4C13
Function calcium channel regulator activity
Related Protein STIM1B; PRKG1; NRXN1; GRM2A; Crisp4; STIM2; SRI; SGK1; HPCAL4; CACNA2D1
Function neuropeptide Y receptor binding
Related Protein PYYA; NPY
Function neuropeptide hormone activity
Related Protein UCN; GAL; PNOC; NPPA; TRH; PENK; VIP; C12orf39; NTS; AVP
Function receptor binding
Related Protein LRRC4B; CYTL1; EDN3; ZAP70; IZUMO1; DECR2; FGF13B; PLG; CLCF1; FGG

Interacting Protein

NPY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPY here. Most of them are supplied by our site. Hope this information will be useful for your research of NPY.
DPP4; FAP; UBQLN1; BAG6; ATP12A; NR1H2; Ccdc64; Rab6b

NPY Related Articles

Czeh, B; Varga, ZKK; et al. Chronic Stress Reduces the Number of GABAergic Interneurons in the Adult Rat Hippocampus, Dorsal-Ventral and Region-Specific Differences. HIPPOCAMPUS 25:393-405(2015).
Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).