NPY
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Official Full Name
neuropeptide Y
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Overview
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that acts as a neurotransmitter in the brain and in the autonomic nervous system of humans; slight variations of the peptide are found in many other animals. In the autonomic system it is mainly produced by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue. In the brain it is produced in various locations including the hypothalamus, and is thought to have several functions, including: increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure and controlling epileptic seizures. -
Synonyms
PYY4; pro-neuropeptide Y;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- SUMO
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NPY-1350H | Recombinant Human NPY, GST-tagged | E.coli | GST | 1-97aa | |
| Human | NPY-29655TH | Recombinant Human NPY | Wheat Germ | N/A | 97 amino acids |
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| Human | NPY-29247TH | Recombinant Human NPY | Wheat Germ | N/A | 69 amino acids |
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| Human | NPY-262H | Recombinant Human NPY Protein, Fc-tagged | HEK293 | Fc |
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| Human | NPY-233H | Recombinant Human NPY protein, His-tagged | E.coli | His |
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| Human | NPY-3726HCL | Recombinant Human NPY 293 Cell Lysate | HEK293 | N/A |
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| Human | NPY-1267H | Recombinant Human NPY Protein, His-tagged | E.coli | His |
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| Human | NPY-6052H | Recombinant Human NPY Protein, GST-tagged | Wheat Germ | GST |
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| Human | NPY-4718H | Recombinant Human NPY Protein (Tyr29-Trp97), N-His tagged | Mammalian cells | N-His | Tyr29-Trp97 |
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| Human | NPY-4719H | Recombinant Human NPY Protein (Tyr29-Trp97), N-SUMO tagged | E.coli | N-SUMO | Tyr29-Trp97 |
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| Human | NPY-6654HF | Recombinant Full Length Human NPY Protein, GST-tagged | In Vitro Cell Free System | GST | 97 amino acids |
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| Human | NPY-344HF | Active Recombinant Full Length Human NPY Protein | In Vitro Cell Free System | 97 amino acids |
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| Rat | Npy-7870R | Recombinant Rat Npy protein, His & GST-tagged | E.coli | His/GST | Pro31~Trp98 |
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| Rhesus Macaque | NPY-3086R | Recombinant Rhesus monkey NPY Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | NPY-2905R | Recombinant Rhesus Macaque NPY Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | NPY-2905R-B | Recombinant Rhesus Macaque NPY Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | NPY-8700Z | Recombinant Zebrafish NPY | Mammalian Cell | His |
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| Chicken | NPY-7022C | Recombinant Chicken NPY | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- NPY Related Articles
- NPY Related Research Area
NPY involved in several pathways and played different roles in them. We selected most pathways NPY participated on our site, such as cAMP signaling pathway, Adipocytokine signaling pathway, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | RELA;CALM1;PTGER3;MC2R;CAMK2D;ATP2B4;HCN2;BAD;ATP1A1 |
| Adipocytokine signaling pathway | G6PC;TNFRSF1A;ADIPOQB;PRKAG3B;ACSL1A;NFKBIAB;SOCS3;PRKAG2;PRKCQ |
| Regulation of lipolysis in adipocytes | NPR1;INS;PIK3R5;AKT2;PRKG2;PIK3CD;NPY1R;PRKACG;INS1 |
| Alcoholism | SLC29A1;GM14482;GM14483;HIST1H4A;HIST1H2AF;H2AFB2;H3F3B;HRAS;CAMKK2 |
NPY has several biochemical functions, for example, G-protein coupled receptor activity, calcium channel regulator activity, neuropeptide Y receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPY itself. We selected most functions NPY had, and list some proteins which have the same functions with NPY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | TMTOPS2B;APLNR;OLFCD2;LPAR1;LPAR6;CALCRLA;MRGPRA8;TAS2R202;OR2L2 |
| calcium channel regulator activity | NPY2R;SGK1;GRM2;CACNB2;STIM2;SRI;GNB2;CRISP1;TSPAN13A |
| neuropeptide Y receptor binding | PYYA;NPY |
| neuropeptide hormone activity | NPFFL;NTS;PPY;UCN;TRH;C12orf39;PRLH;PYY;AVP |
| receptor binding | TNFSF9;HCK;NPFF;TNFSF13B;CD276;FRK;LRRC4B;ARPP19A;GDNF |
NPY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPY here. Most of them are supplied by our site. Hope this information will be useful for your research of NPY.
DPP4; FAP; UBQLN1; BAG6; ATP12A; NR1H2; Ccdc64; Rab6b
- Q&As
- Reviews
Q&As (5)
Ask a questionWhile there are currently no NPY-based therapies approved for depression, research is exploring the potential of targeting NPY pathways for novel antidepressant treatments.
NPY has been shown to have anticonvulsant properties and may play a role in regulating seizure activity in the brain.
Research suggests that NPY-based therapies may have potential in the treatment of epilepsy, although more studies are needed.
NPY has been found to have an anxiolytic effect, meaning it can reduce anxiety and stress levels in the brain.
NPY has also been implicated in neurodegenerative disorders, such as Alzheimer's disease, and is being studied for its potential neuroprotective effects.
Customer Reviews (3)
Write a reviewThis aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.
the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the NPY protein.
Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.
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