nqo1
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  • Official Full Name
  • NAD(P)H dehydrogenase, quinone 1
  • Background
  • This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This proteins enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimers disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • NQO1; NAD(P)H dehydrogenase, quinone 1; DTD; QR1; DHQU; DIA4; NMOR1; NMORI; NAD(P)H dehydrogenase [quinone] 1; azoreductase; diaphorase-4; DT-diaphorase; dioxin-inducible 1; menadione reductase; quinone reductase 1; phylloquinone reductase; NAD(P)H:quinone oxireductase; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; diaphorase (NADH/NADPH) (cytochrome b-5 reductase);
Cat.#:NQO1-001HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NQO1 Protein
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Cat.#:NQO1-6062HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NQO1 Protein, GST-tagged
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Cat.#:NQO1-1393HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NAD(P)H Dehydrogenase, Quinone 1, His-tagged
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Cat.#:Nqo1-721RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat NAD(P)H Dehydrogenase, Quinone 1
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Cat.#:NQO1-1352HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NQO1, GST-tagged
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Cat.#:NQO1-136HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human NQO1 Protein
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Cat.#:NQO1-138HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NQO1 protein, His-tagged
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Cat.#:NQO1-197HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NQO1
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Cat.#:NQO1-29158THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NQO1, His-tagged
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Cat.#:NQO1-377HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NAD(P)H Dehydrogenase, Quinone 1
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Cat.#:Nqo1-1919MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nqo1 protein, His & T7-tagged
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Cat.#:Nqo1-1920RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nqo1 protein, His & T7-tagged
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Cat.#:NQO1-4058RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NQO1 Protein
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Cat.#:Nqo1-722RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nqo1
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Cat.#:Nqo1-723RTag:His/SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nqo1 protein, His/sumo-tagged
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Cat.#:NQO1-3090RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NQO1 Protein, His-tagged
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Cat.#:NQO1-4998CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NQO1
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Cat.#:NQO1-8015ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NQO1
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Cat.#:NQO1-3725HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NQO1 293 Cell Lysate
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Cat.#:Kit-0633Tag:
Source (Host):Species:
Product nameNQO1 Activity Assay Kit
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Involved Pathway

Nqo1 involved in several pathways and played different roles in them. We selected most pathways Nqo1 participated on our site, such as AhR pathway, Dopamine metabolism, Estrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Nqo1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AhR pathway
CYP1A1; CYP1B1; CDKN1A; PTGES3; CYP1A2; EGFR; CDC37; JUN; CDKN1B; JUND
Dopamine metabolism
DDC; NQO1; COMT
Estrogen metabolism
ARSE; CYP1A1; NQO1; ARSD; COMT; CYP1B1
Keap1-Nrf2 Pathway
NQO1; AIMP2
Metabolism
CYP2K19; CPNE6; CTRC; CKM; SLC5A4; INSIG1; ACY3; BSG; ARL2; SLC4A1B
Metabolism of amino acids and derivatives
ACMSD; NAGS; DAO1; SLC25A15A; AFMID; CKMT2; LSM1; HIBADH; BHMT2; CKMT1B
Metabolism of polyamines
AZIN2; OAZ1A; CKBA; PAOX; SLC25A15A; NAGS; SAT1B; OAZ2; OAZ2B; CKMB
Oxidative Stress
NFIX; TXNRD2; TXN2; JUNBA; NOX4; NQO1

Protein Function

Nqo1 has several biochemical functions, for example, NAD(P)H dehydrogenase (quinone) activity, cytochrome-b5 reductase activity, acting on NAD(P)H, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Nqo1 itself. We selected most functions Nqo1 had, and list some proteins which have the same functions with Nqo1. You can find most of the proteins on our site.
Function
Related Protein
Function NAD(P)H dehydrogenase (quinone) activity
Related Protein NQO1; CBR4
Function cytochrome-b5 reductase activity, acting on NAD(P)H
Related Protein CYB5R4; CYB5R2; POR; CYB5R1; CYB5RL; NQO1; CYB5R3
Function identical protein binding
Related Protein AKT1; BRI3; TARDBP; CLDN14; VWF; AIRE; UBQLN4; MUL1; BIRC5; CCL4
Function poly(A) RNA binding
Related Protein HNRNPK; KHDRBS3; VCP; DUSP11; DDX28; SRSF4; FLNA; EXOSC8; ZNF326; HIST1H4E
Function protein binding
Related Protein UBR2; EIF4G2; CCDC92; C2orf63; PPP2R2C; PLXNB2; CENPI; LDB1; MEN1; CRYBA4
Function superoxide dismutase activity
Related Protein PRNPA; SOD3A; SOD2; CCS; NQO1; SOD1

Interacting Protein

Nqo1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Nqo1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Nqo1.
ING1; Tp63; Tp63; NDUFS7; VCAM1

Nqo1 Related Articles

Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
Kim, H; Rigell, CJ; et al. Antagonistic Effects of Anti-EMMPRIN Antibody When Combined with Chemotherapy Against Hypovascular Pancreatic Cancers. MOLECULAR IMAGING AND BIOLOGY 16:85-94(2014).