nr1h4
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  • Official Full Name
  • nuclear receptor subfamily 1, group H, member 4
  • Background
  • This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
  • Synonyms
  • NR1H4; nuclear receptor subfamily 1, group H, member 4; BAR; FXR; HRR1; HRR-1; RIP14; bile acid receptor; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X nuclear receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14;
Cat.#:NR1H4-156HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H4 Protein, His/GST-tagged
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Cat.#:NR1H4-6071HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR1H4 Protein, GST-tagged
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Cat.#:Nr1h4-157RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr1h4 Protein, His/GST-tagged
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Cat.#:NR1H4-1036HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H4, GST-tagged
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Cat.#:NR1H4-1038HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H4, Ligand Binding Domain, GST-tagged
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Cat.#:NR1H4-117HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NR1H4, GST-tagged
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Cat.#:NR1H4-26712THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H4, His-tagged
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Cat.#:NR1H4-3066HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H4, His-tagged
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Cat.#:Nr1h4-07RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr1h4, His-tagged
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Cat.#:NR1H4-4064RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR1H4 Protein
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Cat.#:NR1H4-5689CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR1H4
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Cat.#:NR1H4-692ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NR1H4
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Cat.#:NR1H4-1037HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H4, Ligand Binding Domain
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Cat.#:NR1H4-3719HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR1H4 293 Cell Lysate
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Involved Pathway

NR1H4 involved in several pathways and played different roles in them. We selected most pathways NR1H4 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1H4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Bile secretion
SLCO1A2; ADCY6; SLC51B; ATP1B4; KCNN2; NCEH1; ADCY8; RXRA; ABCB1; SCARB1

Protein Function

NR1H4 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, bile acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1H4 itself. We selected most functions NR1H4 had, and list some proteins which have the same functions with NR1H4. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein SOX10; HOXB5; NR5A2; GZF1; TFAP2C; SFPQ; RXRB; ARID3B; MSC; SPI1
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein RORCA; NR2F1B; NR1D2; AHR; NR1I3; NR4A2; PGR; NR1I2; NR2F6B; NR1H2
Function bile acid binding
Related Protein AKR1C2; NR1H4; STARD5; FABP1; AKR1C21; FABP6; PYGL; PLA2G1B; FABP10A
Function bile acid receptor activity
Related Protein NR1H4; GPBAR1
Function chenodeoxycholic acid binding
Related Protein NR1H4
Function ligand-dependent nuclear receptor binding
Related Protein SMARCE1; ISL1; NCOA1; BAZ2A; NCOA3; ARID1A; NCOR2; UBA3; MED1; TRIM24
Function protein binding
Related Protein SCYL3; MUS81; ZMYND11; COMMD2; CDC14B; MTA2; PARN; ANGPTL4; ZNF460; C2orf51
Function retinoid X receptor binding
Related Protein NR0B2; NSD1; HMGA1-RS1; RARB; VDR; NRIP1; FUS; RARG; NR4A2; HMGA1
Function sequence-specific DNA binding
Related Protein FOXE3; FOXR2; NKX2.1; CSRNP3; FOXI3B; POU5F1; E2F1; ZFP536; DHARMA; HOXA2B
Function steroid hormone receptor activity
Related Protein PAQR7; NR1H2; THRB; PPARG; ESRRA; NR1D2B; PGR; PPARA; RXRAB; NR4A1
Function thyroid hormone receptor activity
Related Protein THRA; NR1D4A; NR2F6; BRD8; THRB; THRAA; NR4A3; NR1D4B; NR1D2A; NR1H4
Function transcription coactivator activity
Related Protein NEUROD1; CTNNB1; ABT1; TAF12; TADA1; APEX1; MED1; PARK7; LPIN2; KAT5
Function transcription corepressor activity
Related Protein ZHX3; NR2F2; ATF3; DR1; MYBBP1A; NRIP1; AES; WNT4; SKOR1; KCNIP3
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein T; THRA; MYF5; MYOD1; OLIG2; USF1; SNAI2; SPI1; POU4F1; GATA6
Function transcription factor activity, sequence-specific DNA binding
Related Protein SMAD3A; SOLH; RARAB; TAF1B; HOXB3A; ZNF436; NR1D4B; NR1H4; GRHL2; NR3C1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein DDIT3; NEUROD1; WT1; GABPA; ZFP750; CRX; KLF15; CREB3L2; EGR2; FOXC2
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein CREB1; NKX2-5; JUN; KLF4; FOXH1; PITX1; NOTCH1; LMO2; PPARA; CLOCK
Function zinc ion binding
Related Protein SETDB1; BMP1A; KDM4A; GATA5; HE2; CNBPA; CA5B; FHL5; POLR2I; DTX3

Interacting Protein

NR1H4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1H4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1H4.
ESR1; GRB2; RELA; SMARCD1; abcbb_human_gene

NR1H4 Related Articles

Xia, X; Qu, B; et al. Analyzing time-series microarray data reveals key genes in spinal cord injury. MOLECULAR BIOLOGY REPORTS 41:6827-6835(2014).
Yang, H; Jiang, J; et al. Molecular characterization, tissue expression profile and SNP analysis of the porcine NR1H4 gene. MOLECULAR BIOLOGY REPORTS 41:7009-7014(2014).