NR1H4 Protein, nuclear receptor subfamily 1, group H, member 4


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Official Full Name nuclear receptor subfamily 1, group H, member 4
Background This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Synonyms NR1H4; nuclear receptor subfamily 1, group H, member 4; BAR; FXR; HRR1; HRR-1; RIP14; bile acid receptor; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X nuclear receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14;
    • Species :
    • Chicken
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR1H4-1036H Recombinant Human NR1H4, GST-tagged E.coli GST
    Human NR1H4-1037H Recombinant Human NR1H4, Ligand Binding Domain E.coli N/A
    Human NR1H4-1038H Recombinant Human NR1H4, Ligand Binding Domain, GST-tagged E.coli GST
    Human NR1H4-117H Recombinant Human NR1H4, GST-tagged Sf9 Insect Cell GST
    Human NR1H4-156H Recombinant Human NR1H4 Protein, His/GST-tagged E.coli His/GST
    Human NR1H4-26712TH Recombinant Human NR1H4, His-tagged E.coli His
    Human NR1H4-3066H Recombinant Human NR1H4, His-tagged E.coli His
    Human NR1H4-3719HCL Recombinant Human NR1H4 293 Cell Lysate HEK293 N/A
    Human NR1H4-6071H Recombinant Human NR1H4 Protein, GST-tagged Wheat Germ GST
    Rat Nr1h4-07R Recombinant Rat Nr1h4, His-tagged E.coli His
    Rat Nr1h4-157R Recombinant Rat Nr1h4 Protein, His/GST-tagged E.coli His/GST
    Rat NR1H4-4064R Recombinant Rat NR1H4 Protein Mammalian Cell His
    Chicken NR1H4-5689C Recombinant Chicken NR1H4 Mammalian Cell His
    Zebrafish NR1H4-692Z Recombinant Zebrafish NR1H4 Mammalian Cell His

    NR1H4 involved in several pathways and played different roles in them. We selected most pathways NR1H4 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1H4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile secretion SLC27A5; ATP1B1; EPHX1; ATP1B2; ABCB1; ATP1A2; Car2; CA2; ATP1A1; FXYD2

    NR1H4 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, bile acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1H4 itself. We selected most functions NR1H4 had, and list some proteins which have the same functions with NR1H4. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II distal enhancer sequence-specific DNA binding GZF1; CDX2; ARID3B; H3F3A; HNRNPC; RUVBL2; NFKB1; CREB1; H2AFZ; PROP1
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR5A5; STAT3; NR5A1B; NR2F2; NR1D2; NR2F6B; NR1H4; HNF4A; NR4A2; VDRA
    bile acid binding AKR1C2; AKR1C21; PYGL; FABP10A; FABP1; FABP6; PLA2G1B; STARD5; NR1H4
    bile acid receptor activity NR1H4; GPBAR1
    chenodeoxycholic acid binding NR1H4
    ligand-dependent nuclear receptor binding BAZ2A; SLC30A9; PROX1; TRIP4; NCOA2; SRA1; TADA3; PPARGC1A; MED1; NR1H4
    protein binding KIAA1737; BCKDK; PARP1; APOB; AGBL4; KIAA0368; MGARP; GTF2F2; ZBTB5; RNF182
    retinoid X receptor binding NCOA1; NR4A2; RARG; MED25; RARB; FUS; NR0B2; NR1H2; HMGA1; NR1H4
    sequence-specific DNA binding OTPB; ZNF394; TRP63; NFE2L2A; TAF2; HOXB5A; CUX2; SPIB; HLFA; HMX2
    steroid hormone receptor activity ESRRG; PGR; RORCB; ESR1; NR1H5; ESRRB; PPARAA; HNF4G; NR4A1; NR1D4A
    thyroid hormone receptor activity BRD8; NR1D4A; NR1D4B; NR1I3; NR1H4; NR1D2A; THRB; THRAA; NR2F6; NR4A3
    transcription coactivator activity SMARCA2; SMARCE1; CITED4; MED26; NPM1; MED16; SNW1; MAK; RIPK3; HINFP
    transcription corepressor activity TRIM28; JUNB; ZHX2; ELK3; PBXIP1; IRF2BP2; FEV; LDB1; BASP1; MXI1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding NKX2; NKX2-5; TFAP4; PDX1; MEF2C; ATF1; USF2; POU3F3; FOXF2A; OLIG2
    transcription factor activity, sequence-specific DNA binding ZNF565; ZFP27; ELF3; MEF2C; TFCP2; ZNF215; NR6A1B; NFAT5A; NFATC1; ZNF726
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NR2E1; FOXJ2; RAX; BATF; FOXC2; ELF1; ARID3B; SREBF1; BCL11B; ATF4
    transcriptional activator activity, RNA polymerase II transcription factor binding NR1H4; GBX2; PPARA; PITX1; MIXL1; CREB1; NFE2L1; CLOCK; LMO2; MED12
    zinc ion binding ADAMTSL3; NR4A2; SRSF7A; PTER; MORC3; CPA4; MORC3B; ZMAT4; LONRF1L; RNFT1

    NR1H4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1H4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1H4.

    ESR1; GRB2; RELA; SMARCD1; abcbb_human_gene

    Xia, X; Qu, B; et al. Analyzing time-series microarray data reveals key genes in spinal cord injury. MOLECULAR BIOLOGY REPORTS 41:6827-6835(2014).
    Yang, H; Jiang, J; et al. Molecular characterization, tissue expression profile and SNP analysis of the porcine NR1H4 gene. MOLECULAR BIOLOGY REPORTS 41:7009-7014(2014).

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