Recombinant Human NR1H4, GST-tagged

• Cat.No.: NR1H4-117H
• Product Overview: Recombinant Human GST-tagged Farnesoid X receptor ligand-binding domain (FXR-LBD) consists of a 218 a.a. GST tag, a 13 a.a. flexible linker and a 246 a.a. FXR-LBD, Acc# AAI30574.1, amino acids 231-476, was expressed in baculovirus-infected insect cells and purified using affinity chromatography.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: Farnesoid X receptor (FXR) is also known as nuclear receptor subfamily 1, group H, member 4 (NR1H4).
• Form: 50 mM Tris-HCl pH 8.0, 150 mM NaCl, 0.5 mM EDTA, 3 mM Dithiothreitol, 7 mM reduced glutathione, 20% glycerol.
• Purity: >90%
• Applications: Ligand binding and coactivator peptide recruitment assays.
• Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.

Gene Information

• Gene Name: NR1H4 nuclear receptor subfamily 1, group H, member 4 [ Homo sapiens ]
• Official Symbol: NR1H4
• Synonyms: NR1H4; nuclear receptor subfamily 1, group H, member 4; bile acid receptor; FXR; HRR 1; HRR1; RIP14; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X nuclear receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14; BAR; HRR-1; MGC163445
• Gene ID: 9971
• mRNA Refseq: NM_001206977
• Protein Refseq: NP_001193906
• MIM: 603826
• UniProt ID: Q96RI1
• Chromosome Location: 12q23.1
• Pathway: Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem; RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem
• Function: RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid binding; bile acid binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-dependent nuclear receptor binding; metal ion binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; steroid hormone receptor activity; thyroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; zinc ion binding