Recombinant Human NR1H4 Protein, GST-tagged

• Cat.No.: NR1H4-6071H
• Product Overview: Human NR1H4 full-length ORF (ADR83011.1, 1 a.a. - 476 a.a.) recombinant protein with GST tag at N-terminal.

Specification

• Description: This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 78.8 kDa
• AA Sequence: MGSKMNLIEHSHLPTTDEFSFSENL FGVLTEQVAGPLGQNLEVEPYSQYS NVQFPQVQPQISSSSYYSNLGFYPQ QPEEWYSPGIYELRRMPAETLYQGE TEVAEMPVTKKPRMGASAGRIKGDE LCVVCGDRASGYHYNALTCEGCKGF FRRSITKNAVYKCKNGGNCVMDMYM RRKCQECRLRKCKEMGMLAECMYTG LLTEIQCKSKRLRKNVKQHADQTVN EDSEGRDLRQVTSTTKSCREKTELT PDQQTLLHFIMDSYNKQRMPQEITN KILKEEFSAEENFLILTEMATNHVQ VLVEFTKKLPGFQTLDHEDQIALLK GSAVEAMFLRSAEIFNKKLPSGHSD LLEERIRNSGISDEYITPMFSFYKS IGELKMTQEEYALLTAIVILSPDRQ YIKDREAVEKLQEPLLDVLQKLCKI HQPENPQHFACLLGRLTELRTFNHH HAEMLMSWRVNDHKFTPLLCEIWDV Q
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NR1H4 nuclear receptor subfamily 1, group H, member 4 [ Homo sapiens ]
• Official Symbol: NR1H4
• Synonyms: NR1H4; nuclear receptor subfamily 1, group H, member 4; bile acid receptor; FXR; HRR 1; HRR1; RIP14; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X nuclear receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14; BAR; HRR-1; MGC163445
• Gene ID: 9971
• mRNA Refseq: NM_001206977
• Protein Refseq: NP_001193906
• MIM: 603826
• UniProt ID: Q96RI1