nr4a1
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  • Official Full Name
  • nuclear receptor subfamily 4, group A, member 1
  • Background
  • Nur77, also known as TR3 and NGFI-B, is an immediate-early response gene and an orphan member of the steroid/thyroid/retinoid receptor superfamily (1-3). Nur77 is composed of an amino-terminal transactivation domain, a central DNA-binding domain and a car
  • Synonyms
  • NR4A1; nuclear receptor subfamily 4, group A, member 1; nuclear receptor subfamily 4 group A member 1; hormone receptor; nuclear protein N10; orphan nuclear receptor HMR; nuclear hormone receptor NUR/77; Hmr; N10; TR3; Gfrp; Hbr1; NP10; TIS1; GFRP1; Hbr-1; NGFIB; nur77; NGFI-B
Cat.#:NR4A1-6093HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR4A1 Protein, GST-tagged
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Cat.#:NR4A1-12HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NR4A1 protein, MYC/DDK-tagged
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Cat.#:NR4A1-1360HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR4A1, GST-tagged
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Cat.#:NR4A1-28049THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NR4A1
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Cat.#:NR4A1-30494THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NR4A1
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Cat.#:NR4A1-10871MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NR4A1 Protein
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Cat.#:NR4A1-4070RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR4A1 Protein
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Cat.#:NR4A1-394ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NR4A1
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Cat.#:NR4A1-1219HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NR4A1 cell lysate
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Involved Pathway

NR4A1 involved in several pathways and played different roles in them. We selected most pathways NR4A1 participated on our site, such as MAPK signaling pathway, PIK-Akt signaling pathway, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RPS6KA3A; FGF6B; Casp3; NLK2; NTRK1; MAPK10; MKNK2B; MECOM; RPS6KAL; GADD45BB
PIK-Akt signaling pathway
CCNE1; RPTOR; ANGPT2; PPP2R5C; ITGA5; IFNA2; KIT; NRAS; ITGB4; IL7
Aldosterone synthesis and secretion
SCARB1; CAMK1D; GNAQ; ITPR2; CAMK2D; GNAS; PRKCE; AKR1C1; DDX1; CACNA1H

Protein Function

NR4A1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR4A1 itself. We selected most functions NR4A1 had, and list some proteins which have the same functions with NR4A1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein MBD3A; POLD2; CHD6; ZNF697; PRDM10; THAP11; SETDB1; ATXN1L; PPP1R10; HIST1H2AK
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein STAT3; PPARDB; RORC; RORB; NR2F1B; NR5A1B; HNF4G; RORCA; NR1I3; NR2F1
Function protein binding
Related Protein LCORL; KRT17; EXOC4; STAU2; DDI1; RNF149; ERCC3; FBXO9; TUBB4A; DNAJB6
Function protein heterodimerization activity
Related Protein AHR; CENPW; CLCF1; TWIST1; KCNK9; HIST3H3; SRY; MAFA; CD3G; TENM1
Function sequence-specific DNA binding
Related Protein HOXD10A; FOXJ1B; ZBTB4; SALL2; NKX2.2B; NR2E3; PAX3; ZFP191; TLX3; CREB3L3A
Function steroid hormone receptor activity
Related Protein RXRBA; RARAB; NR2F6B; NR6A1; PPARAA; NR5A1B; NR2F6; RXRB; NR5A1; NR2E3
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein POU1F1; PBX1; YBX1; HOXD13; MYOG; E2F4; PATZ1; PLSCR1; NCOA3; SOX9
Function zinc ion binding
Related Protein TRIM2A; TRIM108; LRSAM1; VDR; UPF1; ZDHHC11; TRIM35-21; TRIM37; YAF2; TRAF6

Interacting Protein

NR4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR4A1.
BCL2; TP53; GK; 386677