NR4A2 Protein, nuclear receptor subfamily 4, group A, member 2


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Official Full Name nuclear receptor subfamily 4, group A, member 2
Background This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Synonyms NR4A2; nuclear receptor subfamily 4, group A, member 2; NOT; RNR1; HZF-3; NURR1; TINUR; nuclear receptor subfamily 4 group A member 2; nuclear receptor related 1; T-cell nuclear receptor NOT; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; intermediate-early receptor protein; immediate-early response protein NOT; nur related protein-1, human homolog of; transcriptionally-inducible nuclear receptor; NGFI-B/nur77 beta-type transcription factor homolog; transcriptionally inducible nuclear receptor related 1;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR4A2-2451H Recombinant Human NR4A2 Protein (1-598 aa), His-tagged Yeast His
    Human NR4A2-1020H Recombinant Human NR4A2 Protein, GST-tagged Wheat Germ GST
    Human NR4A2-30493TH Recombinant Human NR4A2 Wheat Germ N/A
    Human NR4A2-3543H Recombinant Human NR4A2 Protein, His-tagged E.coli His
    Human NR4A2-3707HCL Recombinant Human NR4A2 293 Cell Lysate HEK293 N/A
    Human NR4A2-3708HCL Recombinant Human NR4A2 293 Cell Lysate HEK293 N/A
    Mouse NR4A2-10872M Recombinant Mouse NR4A2 Protein Mammalian Cell His
    Rat NR4A2-4071R Recombinant Rat NR4A2 Protein Mammalian Cell His
    Rhesus Macaque NR4A2-3097R Recombinant Rhesus monkey NR4A2 Protein, His-tagged Mammalian Cell His

    NR4A2 involved in several pathways and played different roles in them. We selected most pathways NR4A2 participated on our site, such as Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone synthesis and secretion CAMK4; CALML3; HSD3B4; HSD3B5; CAMK2B; PDE2A; KCNK3; CAMK1G; NR4A2; ADCY1

    NR4A2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR4A2 itself. We selected most functions NR4A2 had, and list some proteins which have the same functions with NR4A2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding GTF2F2A; ZNF829; PPP1R8; KRBA2; TBR1B; TAF1D; TXLNB; MCM6L; ZFP74; POLR1A
    RNA polymerase II core promoter sequence-specific DNA binding GATA1; RREB1; H2AFZ; RUNX2; H3F3A; TP53; TBR1; HNF4A; NFIL3; TRP53
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR2F6B; NR2E3; STAT3; ESRRB; NR2F6A; PPARG; NR2F1; NR2F2; NR1H4; NR2F6
    glucocorticoid receptor binding NRIP1; CEBPB; YWHAH; GRIP1; NR4A2; FKBP4; EP300; STAT3; STAT5B; ETS2
    protein binding MYLIPA; PTPN23; DLL1; SLC6A20; TFAM; RABGGTB; PIK3C2B; CORO1C; RPS28; LRRC4
    protein heterodimerization activity UGT1A6; CHRNB2; BCL11A; Pdgfa&Pdgfb; SOX6; PDZD7; ITGB1A; TFDP3; KCNH1; UGT1A6A
    protein homodimerization activity ANO2; KCNH2; TRIM5; PVRL1B; GSTM1; SMAD4; GSTA4; ANXA9; BAXB; BIRC5
    retinoid X receptor binding RARB; NR1H4; NR1H2; FUS; NCOA1; VDR; MED25; NR0B2; NRIP1; NCOR1
    steroid hormone receptor activity NR5A1; NR0B1; NR1D1; NR0B2; RARG; NR2F1; NR1D4A; THRB; NR5A1B; PGRMC2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NR5A2; ETV6; POU3F2; ONECUT2; TFAP2B; STAT3; DLX3; TRP63; TFAP2E; RUNX2
    zinc ion binding NPLOC4; FBXO30; CD4; TRIM69; POLR2I; MGRN1A; MMP1; APOBEC3G; CA5B; TRIM35-7

    NR4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR4A2.


    Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
    Moon, M; Jeong, I; et al. Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY 132:254-262(2015).

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