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NUDT2

  • Official Full Name

    nudix (nucleoside diphosphate linked moiety X)-type motif 2

  • Overview

    This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified.
  • Synonyms

    NUDT2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; APAH1; bis(5-nucleosyl)-tetraphosphatase [asymmetrical]; Ap4A hydrolase 1; Ap4Aase; bis(5 nucleosyl) tetraphosphatase (asymmetrical); diadenosine 5; 5 P1; P4 tetraphosphate pyrophosphohydrolase; diadenosine tetraphosphatase; 2310051L06Rik; AA939917; Ap4A hydrolase; APAH 1; Bis(5 nucleosyl) tetraphosphatase [asymmetrical]; Diadenosine 5,5 P1,P4 tetraphosphate asymmetrical hydrolase; Diadenosine 5,5-P1,P4-tetraphosphate pyrophosphohydrolase; EC 3.6.1.17; MGC10404; Nucleoside diphosphate linked moiety X motif 2; Nudix motif 2; Nudix-type motif 2; NUDT 2; OTTHUMP00000021256; OTTHUMP00000021257; OTTHUMP00000021258; OTTHUMP00000021259; nucleoside diphosphate-linked moiety X motif 2; bis(5-nucleosyl;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NUDT2-29730TH Recombinant Human NUDT2 N/A
Human NUDT2-2532H Recombinant Human NUDT2 protein, His-tagged E.coli His Met1-Ala147
Human NUDT2-957H Recombinant Human NUDT2, His-tagged E.coli His
Human NUDT2-1404H Recombinant Human NUDT2, GST-tagged E.coli GST 1-149aa
Human NUDT2-3647HCL Recombinant Human NUDT2 293 Cell Lysate HEK293 N/A
Human NUDT2-3648HCL Recombinant Human NUDT2 293 Cell Lysate HEK293 N/A
Human NUDT2-6279H Recombinant Human NUDT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NUDT2-3664H Recombinant Human NUDT2 protein, GST-tagged E.coli GST 1-147aa
Mouse NUDT2-10971M Recombinant Mouse NUDT2 Protein Mammalian Cell His
Mouse NUDT2-6255M Recombinant Mouse NUDT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nudt2-4539M Recombinant Mouse Nudt2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NUDT2-6255M-B Recombinant Mouse NUDT2 Protein Pre-coupled Magnetic Beads HEK293
Rat NUDT2-4116R Recombinant Rat NUDT2 Protein Mammalian Cell His
Rat NUDT2-3777R Recombinant Rat NUDT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NUDT2-3777R-B Recombinant Rat NUDT2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NUDT2-3127R Recombinant Rhesus monkey NUDT2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NUDT2-2945R Recombinant Rhesus Macaque NUDT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NUDT2-2945R-B Recombinant Rhesus Macaque NUDT2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NUDT2-472Z Recombinant Zebrafish NUDT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NUDT2 Related Articles

NUDT2 involved in several pathways and played different roles in them. We selected most pathways NUDT2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismENTPD2A.1;POLD4;POLR2GL;POLR1E;NUDT2;POLR3G;CANT1A;URAH;GC3
Pyrimidine metabolismUPRT;ENTPD5;CAD;POLR2J;TXNRD2;NT5C3L;NME7;UPB1;POLE3

NUDT2 has several biochemical functions, for example, GTP binding, bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity, bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT2 itself. We selected most functions NUDT2 had, and list some proteins which have the same functions with NUDT2. You can find most of the proteins on our site.

Function Related Protein
GTP bindingNMUR2;RAB12;NPR1;SEPT12;RAB6C;RAC3;RAB7A;SEPT9;NOA1
bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity
bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity
protein bindingNUP62;PTTG1IP;ADI1;NOL3;RPS3;DCD;TCTN2;NABP1;LSM4

NUDT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT2.

MCM6; ESR2

Albayrak, O; Putter, C; et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 162B:295-305(2013).
Szczepanek, J; Styczynski, J; et al. Identification of the genes expression profile associated with the ex vivo resistance to etoposide in childhood acute leukemias. POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ 66:401-408(2012).
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