NUDT2

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NUDT2

Official Full Name nudix (nucleoside diphosphate linked moiety X)-type motif 2
Background This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified.
Synonyms NUDT2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; APAH1; bis(5-nucleosyl)-tetraphosphatase [asymmetrical]; Ap4A hydrolase 1; Ap4Aase; bis(5 nucleosyl) tetraphosphatase (asymmetrical); diadenosine 5; 5 P1; P4 tetraphosphate pyrophosphohydrolase; diadenosine tetraphosphatase; 2310051L06Rik; AA939917; Ap4A hydrolase; APAH 1; Bis(5 nucleosyl) tetraphosphatase [asymmetrical]; Diadenosine 5,5 P1,P4 tetraphosphate asymmetrical hydrolase; Diadenosine 5,5-P1,P4-tetraphosphate pyrophosphohydrolase; EC 3.6.1.17; MGC10404; Nucleoside diphosphate linked moiety X motif 2; Nudix motif 2; Nudix-type motif 2; NUDT 2; OTTHUMP00000021256; OTTHUMP00000021257; OTTHUMP00000021258; OTTHUMP00000021259; nucleoside diphosphate-linked moiety X motif 2; bis(5-nucleosyl
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NUDT2-1404H Recombinant Human NUDT2, GST-tagged E.coli GST
    Human NUDT2-2532H Recombinant Human NUDT2, His tagged E.coli His
    Human NUDT2-29730TH Recombinant Human NUDT2 N/A
    Human NUDT2-3647HCL Recombinant Human NUDT2 293 Cell Lysate HEK293 N/A
    Human NUDT2-3648HCL Recombinant Human NUDT2 293 Cell Lysate HEK293 N/A
    Human NUDT2-957H Recombinant Human NUDT2, His-tagged E.coli His
    Mouse NUDT2-10971M Recombinant Mouse NUDT2 Protein Mammalian Cell His
    Rat NUDT2-4116R Recombinant Rat NUDT2 Protein Mammalian Cell His
    Rhesus Macaque NUDT2-3127R Recombinant Rhesus monkey NUDT2 Protein, His-tagged Mammalian Cell His
    Zebrafish NUDT2-472Z Recombinant Zebrafish NUDT2 Mammalian Cell His

    NUDT2 involved in several pathways and played different roles in them. We selected most pathways NUDT2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism ADPRM; UOX; NME2B.2; NT5C2B; POLR1B; POLE2; IMPDH1B; PDE4C; POLR2GL; PDE7B
    Pyrimidine metabolism ITPA; POLR2A; TK1; UMPS; CANT1A; NME2A; TWISTNB; POLR3K; CMPK1; TK2

    NUDT2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT2 itself. We selected most functions NUDT2 had, and list some proteins which have the same functions with NUDT2. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding ARF3; DIRAS1; ARF4; ARF1L; EFTUD2; GNL2; DNM1; GLUD1; SEPT9B; RHOF
    bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity NUDT2
    bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity NUDT2
    protein binding PRL2C2; APC; RASSF9; NOTCH2NL; TBC1D1; ANK1; KCTD5; CD14; RWDD1; RNF13

    NUDT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT2.

    MCM6; ESR2

    Albayrak, O; Putter, C; et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 162B:295-305(2013).
    Szczepanek, J; Styczynski, J; et al. Identification of the genes expression profile associated with the ex vivo resistance to etoposide in childhood acute leukemias. POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ 66:401-408(2012).

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