|Official Full Name||notch 2|
|Background||This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]|
|Synonyms||NOTCH2; notch 2; hN2; AGS2; HJCYS; neurogenic locus notch homolog protein 2; Notch homolog 2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Notch2 involved in several pathways and played different roles in them. We selected most pathways Notch2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with Notch2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Dorso-ventral axis formation||ETS2; EGFRA; SPIRE2; MAP2K1; CPEB1; NOTCH3; PIWIL4; FMN2; PPP1R2P9; CPEB1A|
|Notch signaling pathway||ADAM17A; CTBP2; DTX4; LNX1; NCSTN; PSEN2; HER12; RBPJA; DNER; NOTCH1A|
|Thyroid hormone signaling pathway||KRAS; MTOR; ITGB3; AKT2; THRB; NOTCH3; PLCD4; NCOA3; SIN3A; SLC2A1|
|MicroRNAs in cancer||HRAS; RPS6KA5; PRKCE; EP300; MAP2K2; TRP63; SLC7A1; NOTCH2; PDGFB; Abcb1b|
Notch2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by Notch2 itself. We selected most functions Notch2 had, and list some proteins which have the same functions with Notch2. You can find most of the proteins on our site.
|calcium ion binding||PCDHGA6; RASGRP3; PCDHAC2; CALM3; DSG1; PLA2G12A; CBLC; MYL6; TLL1; CRP|
|protein binding||LIMD2; VAMP7; UBE2U; CHD8; HIF1AN; RB1CC1; BCAR3; NEK9; NKD1; NRBF2|
|receptor activity||ANXA2R; TLR2; LRP2; PVRL3; PVRL1B; TNFRSF11B; BTLA; CHRM3; V1RA8; HTR3A|
|transcription factor activity, ligand-activated RNA polymerase II transcription factor binding||NOTCH2|
Notch2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Notch2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Notch2.
ANKRD28; CRKL; IL24; IL13RA2; SMAD1; CST6; ysuR; ITIH5; EPSTI1; FAM84B; MTA3; PSMC3IP; KLK5; ST14; Bmpr1a; RBPJ; Lats2