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Recombinant Human NOTCH2 protein, His-Avi-tagged

Cat.No. : NOTCH2-722H
Product Overview : Human Notch 2 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Leu26-Gln530.
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Description : Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass : The protein has a predicted MW of 57 Kda.
Protein length : Leu26-Gln530
Endotoxin : Less than 1EU per ug by the LAL method.
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Gene Name : NOTCH2
Official Symbol : NOTCH2
Synonyms : AGS2; hN2; neurogenic locus notch homolog protein 2; Notch (Drosophila) homolog 2; notch 2Notch homolog 2 (Drosophila); Notch homolog 2; Notch2; Notch-2
Gene ID : 4853
mRNA Refseq : NM_001200001.2
Protein Refseq : NP_001186930.1
MIM : 600275
UniProt ID : Q04721

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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