orc4
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  • Official Full Name
  • origin recognition complex, subunit 4
  • Background
  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.
  • Synonyms
  • ORC4L; ORC4P; FLJ46668; origin recognition complex subunit 4; OTTHUMP00000162673; origin recognition complex, subunit 4-like; origin recognition complex, subunit 4 homolog; ORC4; origin recognition complex, subunit 4
Cat.#:ORC4-288HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ORC4 Protein, MYC/DDK-tagged
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Cat.#:ORC4-30514THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ORC4
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Cat.#:ORC4-769CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ORC4 Protein, His-tagged
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Cat.#:ORC4-12395ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ORC4
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Involved Pathway

ORC4 involved in several pathways and played different roles in them. We selected most pathways ORC4 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
SSNA1; CSNK2A2; CENPJ; KIF18A; MDM2; CDC6; WRAP53; PSMC3IP; CDKN2D; TGFB3

Protein Function

ORC4 has several biochemical functions, for example, ATP binding, DNA binding, DNA replication origin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC4 itself. We selected most functions ORC4 had, and list some proteins which have the same functions with ORC4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MCM6L; UBA1; IRAK1; ACTC1B; GK2; ACVR2B; BLM; CDK11B; CDKL2; BMPR1BB
Function DNA binding
Related Protein RXRGB; HOXC11A; LHX1A; ZNF302; HER4.2; FOXO3; INSM1A; ZNF705B; GATA3; ONECUT1
Function DNA replication origin binding
Related Protein HSPD1; ORC4; CDC45; ORC3L; ORC4L; MCM10; ORC2L; MCM2; MCM5
Function nucleotide binding
Related Protein UCKL1A; PRKCHA; GSK3AA; ACTB2; INSRA; GUCY2E; CHD1L; RERGLA; RBM41; AKAP17A