Recombinant Human ORC4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ORC4-2850H
• Product Overview: ORC4L MS Standard C13 and N15-labeled recombinant protein (NP_859526) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 50.2 kDa
• AA Sequence: MSSRKSKSNSLIHTECLSQVQRILR ERFCRQSPHSNLFGVQVQYKHLSEL LKRTALHGESNSVLIIGPRGSGKTM LINHALKELMEIEEVSENVLQVHLN GLLQINDKIALKEITRQLNLENVVG DKVFGSFAENLSFLLEALKKGDRTS SCPVIFILDEFDLFAHHKNQTLLYN LFDISQSAQTPIAVIGLTCRLDILE LLEKRVKSRFSHRQIHLMNSFGFPQ YVKIFKEQLSLPAEFPDKVFAEKWN ENVQYLSEDRSVQEVLQKHFNISKN LRSLHMLLMLALNRVTASHPFMTAV DLMEASQLCSMDSKANIVHGLSVLE ICLIIAMKHLNDIYEEEPFNFQMVY NEFQKFVQRKAHSVYNFEKPVVMKA FEHLQQLELIKPMERTSGNSQREYQ LMKLLLDNTQIMNALQKYPNCPTDV RQWATSSLSWLTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ORC4 origin recognition complex subunit 4 [ Homo sapiens (human) ]
• Official Symbol: ORC4
• Synonyms: ORC4; origin recognition complex, subunit 4; ORC4L, origin recognition complex, subunit 4 (yeast homolog) like, origin recognition complex, subunit 4 homolog (S. cerevisiae), origin recognition complex, subunit 4 like (S. cerevisiae), origin recognition complex, subunit 4 like (yeast); origin recognition complex subunit 4; HsORC4; Orc4p; origin recognition complex, subunit 4-like; origin recognition complex, subunit 4 homolog; ORC4L; ORC4P; FLJ46668
• Gene ID: 5000
• mRNA Refseq: NM_181742
• Protein Refseq: NP_859526
• MIM: 603056
• UniProt ID: O43929