p2ry1
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  • Official Full Name
  • purinergic receptor P2Y, G-protein coupled, 1
  • Background
  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor;subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine;nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to;mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably;to platelet aggregation.
  • Synonyms
  • P2RY1; purinergic receptor P2Y, G-protein coupled, 1; P2Y purinoceptor 1; P2Y1; ATP receptor; platelet ADP receptor; P2 purinoceptor subtype Y1
Cat.#:P2RY1-12272MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse P2RY1 Protein
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Cat.#:P2RY1-4233RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat P2RY1 Protein
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Cat.#:P2RY1-3269RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey P2RY1 Protein, His-tagged
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Cat.#:P2RY1-6885CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken P2RY1
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Cat.#:P2RY1-1267HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human P2RY1 cell lysate
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Cat.#:Kit-1467Tag:
Source (Host):Species:
Product nameP2RY1 U2OS β-Arrestin GPCR Assay Kit
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Cat.#:Kit-1468Tag:
Source (Host):Species:
Product nameP2RY1 Activated GPCR Internalization Assay Kit
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Involved Pathway

P2RY1 involved in several pathways and played different roles in them. We selected most pathways P2RY1 participated on our site, such as Rap signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
INS; FGF11; PDGFRA; PIK3R3; FLT1; FYB; FGF20; PLCB2; RAPGEF6; CDC42
Neuroactive ligand-receptor interaction
GABRA1; TACR1; PLG; MC1R; NPY4R; LEPB; MCHR2; MTNR1AA; DRD4-RS; DRD1A
Platelet activation
F2RL3; PPP1R12A; ITGA2B; ITGA2; P2RY12; LCP2; PIK3R1; SRC; ITGB3; MYL12B

Protein Function

P2RY1 has several biochemical functions, for example, A1 adenosine receptor binding, ADP binding, ADP-activated adenosine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RY1 itself. We selected most functions P2RY1 had, and list some proteins which have the same functions with P2RY1. You can find most of the proteins on our site.
Function
Related Protein
Function A1 adenosine receptor binding
Related Protein P2RY1
Function ADP binding
Related Protein GLUD2; ADCK3; ABCG1; ACTA1; PKM; ERN1; VCP; APAF1; MIEF1; PRKAG2
Function ADP-activated adenosine receptor activity
Related Protein P2RY1
Function ATP binding
Related Protein DHX8; CKMT1B; HSPA2; MYLK4; RECQL; NADK2; PKDCC; PRKACB; ABCD4; RPS6KA4
Function ATP-activated adenosine receptor activity
Related Protein P2RY1; P2RY11
Function G-protein coupled purinergic nucleotide receptor activity
Related Protein P2RY13; P2RY4; P2RY14; P2RY2; GPR171; P2RY1; P2RY8; P2RY11; P2RY6; PTAFR
Function protein binding
Related Protein STUB1; APOA4; RAD23B; NKX3; SPHK1; SEC24A; KRT6A; PPP1R7; FBXW7; SPEG
Function protein heterodimerization activity
Related Protein PRMT8; TFAP2B; CLCN3; RRAGA; TENM3; XBP1; HIST1H2AB; MEF2A; BAXA; NKX2
Function receptor activity
Related Protein GRIK5; NOTCH1A; SELS; TNFRSF10B; ITGB1B.2; STRA6; ANTXRL; CCR6; SMAGP; PVRL1A
Function scaffold protein binding
Related Protein CAV2; ATP2B4; VIM; KRT15; KCNH2; P2RY1; HOMER1; SHANK3; PDE4D; TREM2

Interacting Protein

P2RY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RY1.
SLC9A3R1