|Official Full Name||proprotein convertase subtilisin/kexin type 6|
|Background||The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.|
|Synonyms||PCSK6; proprotein convertase subtilisin/kexin type 6; PACE4, paired basic amino acid cleaving system 4; SPC4; subtilisin like proprotein convertase 4; subtilisin like protease; subtilisin/kexin like protease PACE4; subtilisin/kexin-like protease PACE4; s|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PCSK6 involved in several pathways and played different roles in them. We selected most pathways PCSK6 participated on our site, such as Developmental Biology, NGF processing, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Developmental Biology||COL4A5; NR2F2; MYL12A; KALRNB; MED7; EPHB4A; ARPC4; SHB; MED29; DUSP7|
|NGF processing||PCSK5; FURINA; NTF7; FURINB; PCSK6|
|Signal Transduction||ARHGEF1B; NET1; INSL3; PROKR2; PDK3; RLN3A; RAMP3; MDKB; PROKR1A; OPN4.1|
|Signaling by NODAL||DRAP1; ACVR1C; GDF1; PCSK6; TDGF1; CFC1; LEFTY1; FOXH1|
|Signalling by NGF||KIDINS220B; PCSK5; OMG; PRDM4; LINGO1; DNAL4A; DNAL4; AATF; LINGO1B; RIT1|
PCSK6 has several biochemical functions, for example, endopeptidase activity, heparin binding, nerve growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK6 itself. We selected most functions PCSK6 had, and list some proteins which have the same functions with PCSK6. You can find most of the proteins on our site.
|endopeptidase activity||MMP12; PSMA2; PSMA6; TMEM59; CPNE1; ECE1; REN2; FURIN; KLK1B22; PSEN1|
|heparin binding||LPA; PTPRF; HBEGF; APLP1; TENM1; SLIT3; CFH; FGFBP1; PRG2; FGF9|
|nerve growth factor binding||NTRK1; PCSK6; SORT1; FURIN; NGFRB; NGFR|
|serine-type endopeptidase activity||CTSH; KLK1B8; HTRA1A; Gzmg; PRSS37; FURIN; KLK13; MASP1; HPN; F7|
PCSK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK6.
RXRB; CACNA1A; treB