pde11a
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  • Official Full Name
  • phosphodiesterase 11A
  • Background
  • The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PDE11A; phosphodiesterase 11A; dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356
Cat.#:PDE11A-441HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphodiesterase 11A, GST-tagged
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Cat.#:PDE11A-12545MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDE11A Protein
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Cat.#:PDE11A-4325RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDE11A Protein
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Cat.#:PDE11A-3354HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDE11A 293 Cell Lysate
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Cat.#:Kit-1824Tag:
Source (Host):Species:
Product namePDE11A Assay Kit
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Involved Pathway

PDE11A involved in several pathways and played different roles in them. We selected most pathways PDE11A participated on our site, such as Purine metabolism, Morphine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
PKMB; POLR3F; AK8; PRUNE; GC3; NT5C3A; PNP6; NT5E; NME6; PDE6D
Morphine addiction
GNB1; GABRA1; ADRBK2; PDE11A; PDE4A; GNAI1; GABBR1; PRKACA; GNAS; GNG8

Protein Function

PDE11A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE11A itself. We selected most functions PDE11A had, and list some proteins which have the same functions with PDE11A. You can find most of the proteins on our site.
Function
Related Protein
Function 3,5-cyclic-GMP phosphodiesterase activity
Related Protein PDE5A; PDE6G; PDE10A; PDE6H; PDE6B; PDE9A; PDE6C; PDE11A; PDE6A
Function 3,5-cyclic-nucleotide phosphodiesterase activity
Related Protein PDE5AB; PDE4D; PDE3B; PDE9A; PDE6D; PDE8B; PDE5A; PDE8A; PDE10A; PDE11A
Function cAMP binding
Related Protein PRKAR1A; PDE10A; HCN2; PRKAR2B; PRKAR1B; PDE3A; RAPGEF4; HCN4; CNMPD1; PDE4B
Function cGMP binding
Related Protein PDE10A; PDE2A; PDE5A; PRKG1; PDE6G; CNGA3; PRKG2; CNGA5; PDE11A; PRKG1A
Function cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Related Protein PDE2A; USB1; PDE11A; TDP2B; PDE10A
Function cyclic-nucleotide phosphodiesterase activity
Related Protein TDP2B; PDE11A; USB1; PDE2A
Function metal ion binding
Related Protein BTR18; CYP2K17; PPP4C; SEMG2; POLH; ZNF410; ARSE; ITGA2B; PDE2A; RXRAB

PDE11A Related Articles

Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Tadjine, M; Lampron, A; et al. Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). CLINICAL ENDOCRINOLOGY 69:367-373(2008).