pgc
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  • Official Full Name
  • progastricsin (pepsinogen C)
  • Background
  • This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
  • Synonyms
  • progastricsin (pepsinogen C); PEPC; PGII; FLJ99563; Gastricsin; PEPC_HUMAN; Pepsinogen C; PGC; Progastricsin; Pepsinogen II
Cat.#:PGC-1315HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PGC Protein, MYC/DDK-tagged
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Cat.#:PGC-142HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGC Protein, His-tagged
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Cat.#:PGC-1663HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGC, His-tagged
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Cat.#:PGC-3238HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PGC, His tagged
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Cat.#:PGC-446HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGC Protein, His-tagged
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Cat.#:PGC-12681MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PGC Protein
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Cat.#:Pgc-143MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pgc Protein, His/GST-tagged
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Cat.#:Pgc-144RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pgc Protein, His-tagged
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Cat.#:Pgc-2538RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Pgc, His tagged
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Cat.#:PGC-4404RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PGC Protein
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Cat.#:PGC-6440CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PGC
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Cat.#:PGC-132HTag:
Source (Host):Human Gastric MucosaSpecies:Human
Product nameNative Human Pepsinogen II
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Cat.#:PGC-8318HTag:
Source (Host):HumanSpecies:Human
Product nameNative Human PGC
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Cat.#:PGC-2169HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PGC cell lysate
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Cat.#:PGC-1705RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat PGC cell lysate
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Protein Function

PGC has several biochemical functions, for example, aspartic-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGC itself. We selected most functions PGC had, and list some proteins which have the same functions with PGC. You can find most of the proteins on our site.
Function
Related Protein
Function aspartic-type endopeptidase activity
Related Protein NOTS; PGA5; DDI2; CTSE; PGA; CNTNAP5A; PGC; NRIP3; Casp3; SPPL3

PGC Related Articles

Anugraham, M; Everest-Dass, AV; et al. A platform for the structural characterization of glycans enzymatically released from glycosphingolipids extracted from tissue and cells. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 29:545-561(2015).
Michael, C; Rizzi, AM; et al. Quantitative isomer-specific N-glycan fingerprinting using isotope coded labeling and high performance liquid chromatography-electrospray ionization-mass spectrometry with graphitic carbon stationary phase. JOURNAL OF CHROMATOGRAPHY A 1383:88-95(2015).