Recombinant Human PGC Protein

• Cat.No.: PGC-0041H
• Product Overview: Recombinant Human PGC Protein without tag was expressed in HEK293.

Specification

• Description: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
• Source: HEK293 cells
• Species: Human
• Applications: ELISA, CLIA, CG
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Short term (up to 7 days) store at 2–8 centigrade. Long term, store at - 20 centigrade. Avoid multiple freeze/thaw cycles.
• Storage Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH7.4

Gene Information

• Gene Name: PGC progastricsin (pepsinogen C) [ Homo sapiens (human) ]
• Official Symbol: PGC
• Synonyms: PGC; progastricsin (pepsinogen C); gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II; PEPC; PGII; FLJ99563
• Gene ID: 5225
• mRNA Refseq: NM_001166424
• Protein Refseq: NP_001159896
• MIM: 169740
• UniProt ID: P20142