pik3cd
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  • Official Full Name
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
  • Background
  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
  • Synonyms
  • PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
Cat.#:PIK3CD-1896HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged
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Cat.#:PIK3CD-1727HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3CD protein, His & T7-tagged
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Cat.#:PIK3CD-29587THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD
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Cat.#:PIK3CD-52HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CD, GST-tagged
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Cat.#:PIK3CD-1989CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CD
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Cat.#:PIK3CD-11416ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3CD
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Cat.#:PIK3CD-3187HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD 293 Cell Lysate
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Involved Pathway

PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PIP4K2C; INPP4AB; PLCB1; PTEN; PIP4K2B; MINPP1B; PIP5KL1; INPP5K; PI4K2B; SYNJ2
ErbB signaling pathway
MAP2K2A; SHC1; MAP2K4; AKT3A; RAF1; MAPK8A; PIK3R3A; SHC4; MAP2K4B; MAPK1
Ras signaling pathway
RASA4; ELK1; PRKCG; PIK3R2; SHC2; PAK7; PGF; Fgf15; FGF12; INS2
Rap signaling pathway
FGF21; MAPK3; PRKCB; FGF8; FGF2; ITGA2B; PFN2; VEGFA; VASP; ITGB2L
cGMP-PKG signaling pathway
ATP2B1; Adcy4; PPP1R12A; MEF2C; PLCB2; NFATC4; GUCY1B3; MEF2A; MAP2K2; CALM3
cAMP signaling pathway
RHOA; GRIA1; NFATC1; GHRL; TSHR; PRKACB; MAPK3; PTCH1; RAP1B; CALM1
Chemokine signaling pathway
CCR6; Ccl12; VAV1; CXCL10; GNAI3; Adcy4; JAK2; PRKCZ; LYN; PLCB1
HIF- signaling pathway
RBX1; NOX1; IFNGR1; INS2; Trf; ERBB2; ALDOA; EIF4E1B; MAP2K2; HMOX1
FoxO signaling pathway
PIK3CB; TGFBR2; PCK2; GADD45AA; SLC2A4; GABARAPL1; IGF1R; IL7R; TGFBR1A; AKT3A
Phosphatidylinositol signaling system
PIK3R1; SYNJ2; CALML5; MTMR4; INPP5D; INPP5J; CALM3A; MTMR7B; PTENB; TMEM55A
Sphingolipid signaling pathway
MS4A2; LASS5; DEGS1; SPHK2; ABCC1; PPP2R2D; SGPL1; PIK3CD; GNAI2; GNAQ
Phospholipase D signaling pathway
AVP; INS; TSC1; KRAS; DGKZ; PDGFD; GRM4; LPAR2; PIK3R5; LPAR5
mTOR signaling pathway
STRADA; PTENB; PDPK1; RRAGC; RPS6KA1; BRAF; RPS6; EIF4BB; MAPK1; HIF1A
PIK-Akt signaling pathway
PDGFB; IFNA16; THBS4; ANGPT2; PPP2R5D; Fasl; LAMB1; LPAR2; FGF17; CCND3
AMPK signaling pathway
FOXO3; CAB39; G6PC2; CPT1B; PIK3R5; PPP2R2C; ELAVL1; RHEB; RAB14; PFKP
Apoptosis
NFKBIAA; STK24A; NMT1; E2F1; TNFRSF10B; AKT2L; IL1R1; PLEC; RIPK1; JUN
Adrenergic signaling in cardiomyocytes
PLCB1; NETO2; ATP1A1A.1; CACNG4; ADRa1A; PRKACAA; ADCY1A; ATP1A2A; PPP2R5C; ADRA1D
VEGF signaling pathway
NRAS; PRKCBA; RAC1; PIK3CA; AKT2L; RAF1A; RAC2; RAC3A; MAP2K2A; KRAS
Osteoclast differentiation
RELA; NFKB2; FOSL2; PPP3CA; BLNK; FCGR2A; TEC; IKBKB; FCGR4; SPI1
Focal adhesion
SHC3; THBS4A; ACTN3; PARVG; LAMB1A; HRAS; TNK1; TNN; MYL12.1; PRKCA
Signaling pathways regulating pluripotency of stem cells
MYF5; FZD7; GRB2; PCGF6; DLX5; SMAD4; SETDB1; GSK3B; OTX1; AXIN2
Platelet activation
COL27A1; RAP1A; PLCB1; P2RY1; SYK; GNAS; TLN1; PIK3CA; VASP; LCP2
Toll-like receptor signaling pathway
CXCL8B.3; TLR2-1; MAPK8B; CCL4; RIPK1L; TRAF3; CD86; CRFB2; PIK3R3B; IFNA1
Jak-STAT signaling pathway
STAT5B; IL20RA; IFNGR2; CSH2; IL28A; IL20RB; SOCS1A; IRX1; PIK3R5; LEPR
Natural killer cell mediated cytotoxicity
FCER1G; MICA; HLA-E; Casp3; GM-CSF; MAP2K2; VAV2; PAK1; RAET1D; PIK3R5
T cell receptor signaling pathway
PPP3R1; PIK3CB; ZAP70; PAK2; GSK3B; NCK2; CD3D; CD40LG; CD4; ICOS
B cell receptor signaling pathway
GSK3B; ARPC1B; CMTM3; NFKBIE; INPPL1; CD22; ARPC3; HDAC5; VAV2; ARPC2
Fc epsilon RI signaling pathway
MAP2K1; MAP2K4; PLCG1; NRAS; MAPK9; PLA2G4D; PIK3R2; LCP2; PRKCA; LYN
Fc gamma R-mediated phagocytosis
PRKCA; CFL2; SCIN; MAPK3; SPHK1; DOCK2; SYK; WASF1; GAB2; VAV1
TNF signaling pathway
CXCL5; TRAF5; CREB3L2; MAPK1; CXCL2; PIK3R2; BIRC3; MAP2K7; TAB2; RPS6KA5
Leukocyte transendothelial migration
ACTB; ITGAL; MYL5; ROCK1; BCAR1; VAV2; MAPK11; JAM2; MMP2; NOX1
Neurotrophin signaling pathway
CALML3; AKT2; MAP2K2; BRAF; PIK3R5; RPS6KA1; TRP53; CALML5; GAB1; KIDINS220
Cholinergic synapse
GNG8; CREB3L1; GNAI1; PRKCA; PLCB2; PRKCG; KCNJ3; PIK3CA; CHRM2; JAK2
Inflammatory mediator regulation of TRP channels
CAMK2G; PIK3CD; SRC; CALM4; CYP2C37; PIK3R5; PTGER2; KLK1B4; CYP2C39; ALOX12E
Regulation of actin cytoskeleton
MYLK; LIMK1; CYFIP2; ROCK2B; ITGAM; ITGAL; PPP1CB; FGF11A; PXNA; PTK2AA
Insulin signaling pathway
MAPK8; FLOT2A; PRKACA; SHC1; RHEB; FLOT1B; PRKACB; PRKACAB; PPP1R3C; EIF4E1C
Progesterone-mediated oocyte maturation
CDC23; CPEB1B; ARAF; FZR1; PRKACBA; CPEB4; PIK3R1; ANAPC1; PIK3R3B; GNAI3
Estrogen signaling pathway
HSPA8; HSPA1B; AKT1; KCNJ6; KRAS; GNAI3; GNAQ; ITPR1; SHC1; NRAS
Prolactin signaling pathway
PIK3CD; STAT5A; ESR1; PRL; PIK3CA; SOCS4; NFKB1; HRAS; RAF1; LHB
Thyroid hormone signaling pathway
ESR1; STAT1; NOTCH3; PLCB3; PIK3R2; ATP1B3; ATP1A3; SLC9A1; PDPK1; ATP1B4
Oxytocin signaling pathway
PRKAA2; GNAI2; KRAS; RYR1; PIK3R2; PPP1CC; CACNB1; PPP3R2; RCAN1; ITPR1
Regulation of lipolysis in adipocytes
PIK3R5; PRKG2; GNAI2; PIK3R2; PTGER3; PIK3CD; AKT1; PIK3CB; INS1; ABHD5
Type II diabetes mellitus
PIK3CA; INS-IGF2; PIK3CG; PKLR; PKM2; MAPK10; MAFA; SOCS4; ADIPOQ; TNF
Insulin resistance
RELA; PPARGC1B; PRKCBA; PPP1CAA; PTPN1; NR1H2; MGEA5; PRKAG2A; PRKAB1B; PIK3R3
Non-alcoholic fatty liver disease (NAFLD)
PRKAB2; ITCH; NDUFS1; NR1H3; NDUFA1; NDUFA3; PIK3CB; GSK3B; INSR; NDUFS3
Aldosterone-regulated sodium reabsorption
SGK1; PIK3R5; ALPHA-ENAC; PIK3R2; KCNJ1; PIK3CB; ATP1A3; INSR; SCNN1B; PIK3R3
Carbohydrate digestion and absorption
AKT1; ATP1A4; ATP1A1; TAS1R3; PIK3R3; PIK3R1; GNAT3; HK2; G6PC3; AMY1B
Bacterial invasion of epithelial cells
CDH1; ELMO3; ARPC5L; WASF1; ARPC5; SEPT11; CTNNA3; CTNNA1; WASL; WASF2
Chagas disease (American trypanosomiasis)
CALR; CXCL8; IL-8; IRAK4; IL1B2; Fasl; MAPK1; IL1B; PLCB2; TGFB2
Toxoplasmosis
BCL2; HSPA6; H2-AA; MAPK12; PIK3CA; IFNGR2; HLA-DQA1; LAMC1; MAPK10; PIK3R3
Amoebiasis
ARG2; ACTN3; TNF; PRKACG; IL1R1; PIK3R5; COL4A3; SERPINB1B; Itgam&Itgb2; LAMA3
Hepatitis C
RAF1; OAS1B; AKT1; TP53; IFNA13; TRAF3; NFKB1; DDX58; MAPK12; CLDN11
Hepatitis B
EP300; STAT4; TICAM2; TLR3; PIK3R3; CCND1; CCNE2; EGR3; CASP10; PRKCB
Measles
Fasl; IFNA6; PRKCQ; IL1B; OAS1; FASLG; IL12B; IL6; TLR9; IL2RB
Influenza A
DDX39B; OAS1A; IFNA14; PML; HSPA1A; Fasl; HLA-DRB4; CASP9; HLA-DQA2; PIK3CB
HTLV-I infection
IL15; ETS1; IL2RG; KRAS; HLA-B; POLE4; IL2RA; PRKACA; HLA-DMA; MAP3K1
Epstein-Barr virus infection
IRAK1; PRKACG; TBP; NFKBIE; POLR2F; POLR3D; TRAF3; FCER2; TBPL2; HLA-DPA1
Pathways in cancer
WNT5A; PTGER4; DAPK1; CXCL12; LAMA2; PIK3CA; KIT; TGFBR1; ITGA2; IKBKB
Viral carcinogenesis
YWHAB; HIST1H2BQ; HDAC1; NFKB2; EP300; PMAIP1; HIST1H2BL; TTC6; HIST1H2BG; TRADD
Proteoglycans in cancer
MTOR; PLAUR; TLR4; MMP2; WNT8B; DROSHA; CTTN; PIK3R2; Casp3; IL12B
Colorectal cancer
CCND1; MAPK9; PIK3CG; MSH6; ARAF; APC; MAPK10; RAC1; TGFBR1; AKT1
Renal cell carcinoma
PIK3CD; PIK3CA; TGFA; MAPK3; TGFB2; MAPK1; PIK3R3; AKT1; PAK1; PIK3CG
Pancreatic cancer
ARAF; BAD; MAPK1; MAPK8; PLD1; MAPK10; RELA; STAT3; RAC3; CCND1
Endometrial cancer
ARAF; HRAS; AKT1; CDH1; LEF1; MAPK1; SOS1; MAPK3; BAD; AXIN1
Glioma
RAF1; PRKCG; NRAS; MAPK1; PLCG2; HRAS; CALML3; SHC4; RB1; PRKCB
Prostate cancer
PIK3CA; ARID1A; PDGFD; SPRY1; MDM2; RB1; ARAF; SPINK1; PDGFRA; GSK3B
Melanoma
PIK3R5; FGF22; FGF6; PIK3R3; BAD; FGF8; PDGFA; PIK3R1; PDGFRA; FGF19
Chronic myeloid leukemia
PIK3R2; TRP53; TGFB3; SMAD3; RELA; PIK3R5; NRAS; TGFBR2; PIK3CG; TGFB2
Acute myeloid leukemia
EIF4EBP1; CEBPA; STAT5A; CHUK; LEF1; JUP; HRAS; PIK3R1; PIK3R3; PIM2
Small cell lung cancer
XIAP; PIK3CD; LAMA5; RXRG; IKBKG; RARB; AKT1; NFKBIA; CKS2; MAX
Non-small cell lung cancer
RAF1; FHIT; PIK3CG; TRP53; ERBB2; PIK3R3; PIK3R5; TGFA; PIK3CA; MAP2K1
Central carbon metabolism in cancer
G6PD; RET; FGFR2; C12orf5; MET; PDK1; PDHA1; PKM2; MTOR; PDHA2
Choline metabolism in cancer
GPCPD1; CHKB; WAS; RAC1; PIP5K1B; MAPK1; WASF1; MTOR; FOS; SLC5A7

Protein Function

PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3C2B; PIK3C3; PIK3CB; PIK3R3; PIK3CD; PIK3C2G; PIK3CG; PIK3CA; PIK3C2A; ATM
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3CA; PIK3C2G; PIK3CB; PIK3CG; PIK3CD; PIK3C2A; PIK3C2B
Function ATP binding
Related Protein EHD2; CCT6A; DGKD; SPEG; NME2B.1; NADK2; RIPK1; MAPK14; SMC3; CSF1R
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CD; PIK3CA; PIK3C2A; PIK3CB; PIK3CG
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CD; PIK3CB; PIK3CG; PIK3CA
Function protein binding
Related Protein RAB24; Fert2; KLRB1F; PIKFYVE; APAF1; PTPN7; ZNF276; RORA; HSPA6; MLF2

Interacting Protein

PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.
PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY