pik3cd
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  • Official Full Name
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
  • Background
  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
  • Synonyms
  • PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
Cat.#:PIK3CD-1896HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged
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Cat.#:PIK3CD-1727HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3CD protein, His & T7-tagged
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Cat.#:PIK3CD-29587THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD
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Cat.#:PIK3CD-52HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CD, GST-tagged
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Cat.#:PIK3CD-1989CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CD
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Cat.#:PIK3CD-11416ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3CD
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Cat.#:PIK3CD-3187HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD 293 Cell Lysate
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Involved Pathway

PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PLCD1B; IMPA1; IP6K3; PLCD3A; MINPP1B; INPP5KA; NUDT3; PLCG2; INPPL1A; MTMR7
ErbB signaling pathway
SHC4; ERBB3A; PRKCBA; PRKCG; MAPK8A; CAMK2D2; TGFA; CAMK2D; ERBB4; NCK2B
Ras signaling pathway
FGF10; IGF1R; AKT2; REL; PDGFB; GNG13; TEK; FLT1; PAK2; Kitl
Rap signaling pathway
LPAR4; GNAI1; RASGRP3; Kitl; FGF17; GNAQ; PARD6A; GRIN1; FGF16; GNAI3
cGMP-PKG signaling pathway
PPP1CA; ATP2B1; CALM3; PPP3CC; SLC25A4; GNAI1; PDE3B; INS2; MAP2K1; PIK3R1
cAMP signaling pathway
HTR4; CAMK2G; GRIA4; CAMK2B; GRIN3A; CAMK2D; MAP2K1; PLD1; PTGER2; ROCK2
Chemokine signaling pathway
CXCL1; NFKBIA; XCL2; Ccl21a; CXCR3; GNG4; JAK3; GNG10; RAP1A; CRK
HIF- signaling pathway
FLT1; PIK3R5; INS2; PIK3CD; PIK3R3; INS; PRKCB; PIK3CG; NPPA; ANGPT1
FoxO signaling pathway
PRKAB1; GRM1; CCNG2; TGFBR1B; FOXO4; ATG12; ATM; GABARAPL2; IGF1RB; INS2
Phosphatidylinositol signaling system
IMPA2; INPPL1; DGKE; PI4KA; PIK3R2; DGKD; PRKCBB; PIK3CG; PTEN; MTMR2
Sphingolipid signaling pathway
LASS4; TNF; HRAS; PIK3R5; SGPP1; PLCB2; PIK3R3; PIK3R1; RAC1; PPP2R2B
Phospholipase D signaling pathway
PIK3R1; GAB2; PDGFB; GRM2; PIK3R3; PLCB4; SYK; INS; PIK3R5; PIK3CD
mTOR signaling pathway
AKT1; POLDIP3; AKT2L; EIF4BB; RRAGD; RPS6KB1; HIF1AB; PDPK1B; RHEB; MAPK1
PIK-Akt signaling pathway
IL3; HGF; TLR2; PCK2; SGK1; THBS3; IFNA2; CREB3L1; FGF17; CCND3
AMPK signaling pathway
PRKAB2; CAMKK1; FBP2; MAP3K7; IGF1; CREB3L3; PPARG; AKT1S1; CRTC2; ELAVL1
Apoptosis
HIST1H1E; DFFA; CAPN2B; CASP8L1; IL1RAP; ADD1; E2F1; PRKACAB; CASP6; GZMF
Adrenergic signaling in cardiomyocytes
PLCB3; CAMK2D; TPM4; PPP2R2A; ADRa1A; AKT2L; AGTR2; ATP2B2; PPP2R2D; PIK3R3B
VEGF signaling pathway
VEGFAA; MAP2K2; RAC1; PRKCB; RAF1; VEGFA; PPP3CCA; BAD; RAF1A; PPP3CCB
Osteoclast differentiation
NOX3; LILRA3; MAPK13; FCGR3B; LILRA2; FOSL1; TGFB1; PPP3R1; PPP3R2; TEC
Focal adhesion
DIAPH1; VTNB; PTENA; IBSP; MAPK8A; PIK3CB; PAK2; PTK2; PDPK1; CCND1
Signaling pathways regulating pluripotency of stem cells
AKT2; SMAD3; ESRRB; INHBE; FGFR4; HESX1; IGF1R; ID4; HNF1A; BMI1
Platelet activation
VASP; FGG; ITGB3; FGA; MAPK3; ROCK1; COL24A1; PIK3CB; PPP1CB; TLN1
Toll-like receptor signaling pathway
MAP2K2B; MAPK8; CRFB2; IFNAR2; IFNA1; IFNB; TLR2-1; MAP2K4; PIK3R3B; IFNPHI1
Jak-STAT signaling pathway
IL19; IL23R; RAF1B; CRFB16; SOCS6; STAT1B; GH2; FHL1A; IL6R; CNTFR
Natural killer cell mediated cytotoxicity
SHC1; SHC3; TNFSF10; TNFRSF10C; VAV3; CD48; RAET1E; ICAM1; PIK3CB; IFNA17
T cell receptor signaling pathway
MAPK1; RHOA; PAK3; PAK2; PIK3CD; FOS; PIK3CA; Il2; ZAP70; PAK6
B cell receptor signaling pathway
CTNNB2; CMTM3; MAPK1; DOK1; PDK2B; NRAS; AKT1; ITK; LIME1; MAPK3
Fc epsilon RI signaling pathway
PLA2G4A; TNF; NRAS; MAP2K7; IL13; FCER1G; PDPK1; MAPK8; PIK3CB; PIK3R3
Fc gamma R-mediated phagocytosis
INPPL1; FCGR3A; LIMK1; PLA2G4A; cgr2b; GSN; PIK3CA; VAV3; RAC2; FCGR2B
TNF signaling pathway
PIK3CD; Casp3; CCL2; AKT1; TRADD; MMP9; FAS; VEGFC; BAG4; SELE
Leukocyte transendothelial migration
CLDN23; AASS; ACTG1; BCAR1; MYL9; Itgam&Itgb2; MYL2; ACTN4; ACTB; PIK3CG
Neurotrophin signaling pathway
PRDM4; KRAS; PLCG1; MAPK13; NFKBIA; CAMK2D; CAMK2A; SORT1; PIK3R3; IRAK4
Cholinergic synapse
SLC5A7; PIK3R2; GNA11; CAMK2G; GNG7; PIK3CB; PRKCG; PRKACB; ATF4; MAP2K1
Inflammatory mediator regulation of TRP channels
NTRK1; HTR2A; HRH1; CYP2C70; PLA2G4D; PLCG1; HTR2C; PIK3R3; CAMK2D; ALOX12
Regulation of actin cytoskeleton
EZRB; ARPC5LA; BRK1; MYLK3; FGF22; PIK3R1; PDGFAB; RRAS; ITGB1; ITGA3
Insulin signaling pathway
KRAS; CALM; PPP1R3DA; ARAF; SHC4; FLOT2B; GRB2; EIF4E2; G6PC2; EIF4E2RS1
Progesterone-mediated oocyte maturation
CPEB1; BRAF; GNAIA; CDH1-A; GNAI3; ANAPC7; RPS6KA2; AKT2L; MAPK3; RPS6KA6
Estrogen signaling pathway
NOS3; PRKACA; PIK3R1; HSPA1L; CALM2; FOS; ATF4; KRAS; PRKACB; PIK3CG
Prolactin signaling pathway
MAP2K1; FOS; SHC4; INS2; PIK3R3; SOCS2; TH; NRAS; MAPK9; ESR2
Thyroid hormone signaling pathway
ATP1A3; NRAS; RHEB; HDAC2; MED13; KAT2A; SLC16A2; PFKFB2; GATA4; HIF1A
Oxytocin signaling pathway
CAMKK1; ACTB; FOS; PRKAG2; OXT; PRKAG3; PLCB3; NPR1; CALM1; PIK3CA
Regulation of lipolysis in adipocytes
PRKG2; PIK3CB; IRS4; INSR; PLIN1; PRKG1; PIK3CA; PIK3CD; PIK3CG; INS
Type II diabetes mellitus
HK1; PIK3R5; HKDC1; MAFA; MAPK9; PIK3CD; MAPK8; SOCS3; CACNA1G; PIK3CG
Insulin resistance
FOXO1; OGT.1; PRKAG2; MLXIPL; MAPK8B; FOXO1B; SLC27A5; PCK1; PTPRFB; PTPN11
Non-alcoholic fatty liver disease (NAFLD)
COX6B2; NDUFB4; UQCRB; COX4I2; PKLR; NDUFA12; NDUFA2; MAP3K5; NDUFA4; Casp3
Aldosterone-regulated sodium reabsorption
PRKCA; INS; INSR; PRKCG; ATP1A2; PIK3CG; PIK3R3; HSD11B2; FXYD2; ATP1B1
Carbohydrate digestion and absorption
AMY1B; ATP1A1; ATP1A3; FXYD2; SLC2A2; HK1; G6PC3; SLC5A1; PIK3R2; Amy1
Bacterial invasion of epithelial cells
VCL; DNM3; ELMO3; PTK2; ARPC5L; CLTA; CRKL; CLTC; CTNNA1; CAV1
Chagas disease (American trypanosomiasis)
ACE; NFKBIA; PIK3R1; FOS; PLCB2; IL12A; IL6; IKBKG; TLR9; GNA14
Toxoplasmosis
HSPA2; HLA-DRB4; IL10RB; TAB2; HLA-DRB3; GNAI1; IRGM1; IKBKG; H2-AA; HLA-DOA
Amoebiasis
IL12A; IL1B; SERPINB1; SERPINB1B; PRKACG; CTSG; RAB7B; PRKCG; CXCL1; COL27A1
Hepatitis C
IFNA7; IFNA8; OAS1B; IFNA12; CXCL8; CD81; GRB2; PIK3R2; PIK3CA; CLDN2
Hepatitis B
NFATC1; IKBKG; STAT5B; IFNA7; IFNA1; MMP9; Ifna15; ELK1; PRKCA; IKBKB
Measles
PRKCQ; Ifna11; DDX58; TACR1; FASLG; IFNA17; IL2RG; IL1B; MSN; PIK3CA
Influenza A
RAE1; IL1B; HSPA6; TNFRSF10D; H2-AB1; IL8L1; BLB1; KPNA2; IL-8; TNF
HTLV-I infection
HLA-DMB; FOS; CRTC2; CD3E; MYBL1; GPS2; CALR; AKT2; EGR1; NFKB2
Epstein-Barr virus infection
HSPB2; PSMD6; PIK3CB; SFPI1; PIK3CA; TBK1; PRKACB; IKBKB; MAP2K7; PSMC3
Pathways in cancer
AXIN2; STAT3; RET; EPAS1; MSH6; CTNNA3; WNT4; LAMA5; FZD9; FGF12
Viral carcinogenesis
PKM; GTF2H2; HLA-C; MAPKAPK2; HIST1H2BA; TRAF2; MDM2; HPN; HIST1H4A; DDX3X
Proteoglycans in cancer
COL21A1; PIK3CG; MAPK12; FGFR1; RAC1; MTOR; NANOG; PRKCG; WNT2B; TLR4
Colorectal cancer
SMAD4; PIK3CA; BAX; GSK3B; MAPK10; DCC; APPL1; BRAF; PIK3R2; MAP2K1
Renal cell carcinoma
PIK3R2; TCEB1; MAPK1; HIF1A; EP300; FH1; RBX1; PAK3; MAPK3; FH
Pancreatic cancer
SMAD2; MAPK1; RELA; PIK3CB; TGFB1; KRAS; BRCA2; RAF1; STAT1; BAD
Endometrial cancer
ILK; ARAF; CASP9; FOXO3; CCND1; PDPK1; GSK3B; PTEN; PIK3CG; LEF1
Glioma
PIK3R5; BRAF; SHC4; PRKCG; PRKCB; PDGFB; TRP53; KRAS; CALML5; PRKCA
Prostate cancer
CCNE2; MAP2K2; IKBKG; NFKB1; PIK3CG; CREB3L2; IGF1; RB1; SOS1; PIK3CB
Melanoma
MAP2K1; Fgf15; BAD; MAPK1; PDGFRB; IGF1; FGF10; TRP53; MET; PDGFC
Chronic myeloid leukemia
PIK3R3; KRAS; SHC2; CCND1; NRAS; NFKB1; SHC4; TGFB3; BRAF; SOS1
Acute myeloid leukemia
PIK3R1; MYC; STAT3; SOS1; STAT5B; AKT1; CCNA1; PIM2; NRAS; HRAS
Small cell lung cancer
APAF1; CCND1; TRAF2; IKBKG; PIK3R3; MAX; PIK3CG; COL4A1; RXRG; CCNE2
Non-small cell lung cancer
EML4; TGFA; PDPK1; PIK3CB; CASP9; FOXO3; SOS1; ARAF; FHIT; PIK3CA
Central carbon metabolism in cancer
PIK3CA; PIK3CD; AKT2; FGFR2; MTOR; HK1; HK3; MAPK3; SCO2; MAPK1
Choline metabolism in cancer
GPCPD1; RALGDS; DGKQ; SLC22A5; PDGFA; PIK3CA; SLC22A3; PLD2; PLD1; PIK3R3

Protein Function

PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3C3; PIK3CB; ATM; PIK3CD; PIK3C2G; PIK3C2B; PIK3CG; PIK3C2A; PIK3R3; PIK3CA
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3CA; PIK3C2A; PIK3C2B; PIK3C2G; PIK3CD; PIK3CB; PIK3CG
Function ATP binding
Related Protein MYH11; IKBKAP; CCT7; DDX3; SRPK2; PAK2B; EPHA2A; CDC7; ATP2B4; ULK1
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CA; PIK3CD; PIK3CG; PIK3CB; PIK3C2A
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CB; PIK3CG; PIK3CA; PIK3CD
Function protein binding
Related Protein CCDC70; SEC23B; PPP2R2C; SEC16B; EMID2; TROAP; KDM1A; TIMM8A; H3F3C; DLGAP4

Interacting Protein

PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.
PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY