pik3cd
Share
  • Official Full Name
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
  • Background
  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
  • Synonyms
  • PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
Cat.#:PIK3CD-1896HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged
+Inquiry
Cat.#:PIK3CD-1727HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3CD protein, His & T7-tagged
+Inquiry
Cat.#:PIK3CD-29587THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD
+Inquiry
Cat.#:PIK3CD-52HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CD, GST-tagged
+Inquiry
Cat.#:PIK3CD-1989CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CD
+Inquiry
Cat.#:PIK3CD-11416ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3CD
+Inquiry
Cat.#:PIK3CD-3187HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD 293 Cell Lysate
+Inquiry

Involved Pathway

PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
IPPK; NUDT3; NUDT10; PLD4; PIP5K1C; INPP5A; INPP5D; PIK3C3; INPP4AB; MTMR14
ErbB signaling pathway
PRKCB; CDKN1BB; GSK3B; PIK3R2; NCK2; MAPK3; PTK2AA; PAK1; PIK3R3; TGFA
Ras signaling pathway
GNB3; RASAL1; HRAS; LOC608458; FGF20; RHOA; FLT4; RASAL3; PLA2G2E; PLA2G4D
Rap signaling pathway
PIK3CA; PIK3CG; NRAS; INS; FGFR1; PIK3CD; Adcy4; PDGFC; FLT4; FGF2
cGMP-PKG signaling pathway
SLC25A6; CREB3L2; RGS2; GNAI1; ATP2A1; RAF1; AGTR1A; IRS2; CREB3L3; AGTR1B
cAMP signaling pathway
GPR119; VAV3; NFATC1; GRIN3B; SUCNR1; CAMK2B; ATP1B4; RHOA; MAP2K2; MAPK3
Chemokine signaling pathway
AKT1; ARRB1; CCR1; ARRB2; RHOA; GM13306; CCR1L1; CCR9; CCL20; GSK3B
HIF- signaling pathway
INS; INS2; MAP2K1; TIMP1; TF; PIK3CB; NOX3; CAMK2G; PRKCB; GM5506
FoxO signaling pathway
KLF2; INS1; EGFRA; PRKAB1A; PRKAB1B; RAF1A; HRASA; CCNB1; HOMER3; PLK4
Phosphatidylinositol signaling system
MTMR1B; IMPA2; CALM1A; IMPA1; PIK3CA; PIK3R2; PLCE1; MTMR7; CALM1B; PLCB3
Sphingolipid signaling pathway
ASAH1; DEGS1; SGMS1; PPP2R1A; MS4A2; PPP2R2A; SPTLC1; PPP2R5C; BDKRB2; GNAI3
Phospholipase D signaling pathway
PIP5K1A; IL-8; LPAR6; SHC4; PPAP2B; MAPK3; PDGFRA; Adcy4; GRB2; RRAS2
mTOR signaling pathway
RPTOR; EIF4EA; RRAGCA; PIK3R2; DDIT4; EIF4E2; EIF4BB; MTOR; INSB; RPS6KB1
PIK-Akt signaling pathway
ITGA5; PRL; PDGFC; HSP90B1; MTCP1; GNB4; IBSP; RELA; FGF1; TLR2
AMPK signaling pathway
MLYCD; TBC1D1; CPT1A; CREB3L1; STK11; ELAVL1; STRADB; PPP2R1A; PPP2R1B; PPP2R2C
Apoptosis
BNIP3LB; SPNA2; MAP3K14; CASP3A; DCC; HRK; PLEC; PTBP3; PPP3CCB; SATB1
Adrenergic signaling in cardiomyocytes
PPP2R5B; ATP2B1; PRKACBA; GNAIA; AKT2L; PPP2R2CA; AGTR1A; SLC9A1; ADCY8; GNA11A
VEGF signaling pathway
RAC2; PLA2G4AA; PPP3CCA; PPP3R2; MAP2K1; MAP2K2A; AKT1; RAC1; RAC3B; MAPK3
Osteoclast differentiation
IKBKB; FCGR2C; IFNAR1; PIK3R5; IL1B; CSF1; FCGR1; RELB; PPP3CB; SIRP-BETA
Focal adhesion
PIK3CB; MET; ACTB2; TLN2A; PTK2; BIRC3; PIK3R3B; DIAPH1; RAPGEF1; COL2A1B
Signaling pathways regulating pluripotency of stem cells
WNT11; INHBB; PIK3CG; SMAD3; RAF1; WNT3A; OTX1; KRAS; WNT2B; SMARCAD1
Platelet activation
ITGA2B; PIK3CD; PPP1CB; TLN1; SYK; RAP1B; PIK3CA; TBXA2R; PTGS1; VAMP8
Toll-like receptor signaling pathway
MAP2K7; PIK3R2; MAP2K4A; TLR1LA; IL-8; TLR4; TLR2-2; TLR2; MAPK14B; TOLLIP
Jak-STAT signaling pathway
IL15RA; STAT5B; IL4; CRLF2; Il23a; SOCS1A; SOCS1; IL23R; PIAS1; GHRA
Natural killer cell mediated cytotoxicity
MAP2K1; HLA-C; PLCG1; KRAS; IFNA5; BRAF; RAET1L; SOS1; PTK2B; Raet1a
T cell receptor signaling pathway
IFNG; NCK1; GSK3B; DBNLB; CD3D; CABIN1; CBLB; ZAP70; PIK3R1; Il2
B cell receptor signaling pathway
VAV1; AKT1; CD79B; NFATC2; GSK3B; PIK3R3; MAP4K1; PPP3R2; CSK; CD22
Fc epsilon RI signaling pathway
GAB2; MAP2K4; PDPK1; RAC3; PIK3R2; PRKCA; MAP2K6; NRAS; PIK3R5; PLCG1
Fc gamma R-mediated phagocytosis
RAC1; LAT; cgr2b; FCGR1; BIN1; SPHK1; PIP5K1A; PLA2G4F; HCK; PLD1
TNF signaling pathway
MMP9; MAPK12; CXCL2; AKT1; MAP3K5; SOCS3; CREB3L3; TRADD; VCAM1; TRAF2
Leukocyte transendothelial migration
PTK2; PTK2B; MSN; F11R; ACTB; VASP; CLDN23; PIK3R5; MYL9; CXCR4
Neurotrophin signaling pathway
PIK3CA; AKT1; NFKBIB; MAP2K2; BAD; AKT2; PIK3R5; NTF4; PIK3CB; TP73
Cholinergic synapse
KCNQ3; CHRM4; GNAQ; GNGT1; KCNJ4; GNG10; KCNQ4; KCNJ3; CHRNB2; ACHE
Inflammatory mediator regulation of TRP channels
PLA2G4F; CAMK2B; ITPR1; MAPK13; SRC; CALM2; ALOX12E; PIK3CA; TRPV3; GNAQ
Regulation of actin cytoskeleton
ITGA3B; FGF18; RAF1; FGF7; MYH10; MRAS; SCINLB; MYL7; ITGA6B; MOS
Insulin signaling pathway
CALM1A; SHC2; PYGMA; PHKA1; PYGL; PRKAB2; HK2; PDPK1B; RAF1; PRKACBB
Progesterone-mediated oocyte maturation
RPS6KA6; HSP90AA1; CDC26; CDH1-A; PLK1; INS1; PIK3CG; HSP90AB1; FZR1A; Adcy4
Estrogen signaling pathway
HSPA2; GNAI2; NOS3; CREB3L3; CREB3L1; PLCB4; PIK3CG; Adcy4; CALML5; FKBP4
Prolactin signaling pathway
LHCGR; PRL; NEK3; RELA; SOCS7; MAP2K2; ESR2; PIK3CA; SIRPA; STAT3
Thyroid hormone signaling pathway
NRAS; ATP2A2; TSC2; SRC; NCOA1; PIK3CB; DIO1; KAT2B; THRA; PRKCG
Oxytocin signaling pathway
CAMK1G; CACNB1; PPP3CC; PPP3CB; MYLK; CACNA2D3; PRKCB; NFATC3; CALM2; PLCB2
Regulation of lipolysis in adipocytes
LOC100328615; GNAI1; PRKG2; PRKACB; PTGER3; PIK3CB; AQP7; PTGS2; PLIN1; PIK3CA
Type II diabetes mellitus
IKBKB; SLC2A4; CACNA1G; IRS1; SOCS1; PRKCE; MAPK9; IRS4; PKLR; MAPK3
Insulin resistance
PTEN; G6PC; MTOR; PIK3R3; NFKBIA; PIK3CB; FOXO1B; OGT.1; SOCS3B; CRTC2
Non-alcoholic fatty liver disease (NAFLD)
NDUFC2-KCTD14; PPARA; PIK3R1; SDHB; NDUFB3; BAX; NDUFA11; NDUFA8; INS2; PKLR
Aldosterone-regulated sodium reabsorption
INS1; PRKCB; MAPK1; PIK3R1; PRKCG; ATP1A1; PIK3CA; PIK3CB; PIK3R3; PRKCA
Carbohydrate digestion and absorption
AMY2A3; TAS1R2; HK3; HK2; ATP1A2; Amy1; PIK3CB; PLCB2; SLC2A2; AMY1B
Bacterial invasion of epithelial cells
BCAR1; CTNNA1; RHOG; WASL; SHC1; CD2AP; SHC2; CAV3; ELMO1; CLTB
Chagas disease (American trypanosomiasis)
PPP2R2D; CCL3L1; TICAM1; TNFRSF1A; IL12B; TGFB3; RELA; NOS2; CCL3; GNA14
Toxoplasmosis
IL10RB; BIRC3; ITGB1; HLA-DMB; LAMC2; LAMC1; HSPA1L; IKBKG; SOCS1; LAMB4
Amoebiasis
COL4A4; PIK3R2; GNA11; GNAL; Casp3; PLCB2; ACTN3; PRKACA; PLCB1; FN1
Hepatitis C
PIK3CB; EIF2AK2; OCLN; CLDN14; CLDN10; PPP2R1B; STAT1; IFNA14; IFNA17; TRAF2
Hepatitis B
MAP3K1; FAS; BCL2; PCNA; STAT3; PIK3R5; IFNA2; TIRAP; PIK3CA; STAT4
Measles
MX1; TBK1; HSPA2; FASLG; EIF2AK2; TP73; OAS3; RAB9B; PIK3R2; IFNB1
Influenza A
IFNB; FURIN; RSAD2; IFNA12; IL33; IFNA2; IL1A; OAS3; IFNA3; HLA-DRA
HTLV-I infection
SMAD4; ANAPC1; FZD10; HRAS; PPP3CA; ATF4; ANAPC2; CREM; WNT9B; PTTG2
Epstein-Barr virus infection
YWHAG; CDK1; RB1; EP300; EIF2AK4; TYK2; EIF2AK2; HDAC4; HDAC2; CD19
Pathways in cancer
GNAI2; SPI1; LPAR5; MSH2; Pdgfa&Pdgfb; KRAS; PPARD; AXIN2; BIRC8; WNT5A
Viral carcinogenesis
UBR4; PSMC1; HLA-F; NFKB1; TRAF3; GTF2H2C_2; TRAF2; HDAC3; PKM2; GTF2A1
Proteoglycans in cancer
ACTG1; MAP2K1; PIK3CG; FZD8; MSN; FZD3; VTN; CTTN; PIK3R5; CAMK2G
Colorectal cancer
AXIN2; PIK3R2; CASP9; PIK3R3; MSH2; TCF7; TP53; RAC1; AKT1; MAPK9
Renal cell carcinoma
TCEB1; RAPGEF1; RAP1A; CDC42; TGFB2; GAB1; FLCN; TGFA; PIK3R1; TGFB3
Pancreatic cancer
MAPK1; MAP2K1; RAC1; MAPK9; RAC2; PIK3CD; BAD; RALB; PLD1; PIK3CA
Endometrial cancer
AXIN1; PIK3CD; CCND1; AKT2; SOS1; PIK3R1; MAPK1; APC; NRAS; ELK1
Glioma
SHC2; MAPK1; PIK3CB; MAP2K1; SHC4; MDM2; CALML5; CALML3; PLCG1; CAMK2G
Prostate cancer
PDGFRA; MTOR; MAPK1; PTEN; NRAS; HRAS; PIK3CA; PIK3R5; FOXO1; IGF1
Melanoma
FGF22; PDGFD; FGF7; FGF4; PDGFRA; Pdgfa&Pdgfb; PIK3R5; FGF2; ARAF; MDM2
Chronic myeloid leukemia
PIK3R3; MAP2K2; MDM2; CRKL; BAD; STAT5B; CCND1; CTBP1; SMAD3; BCR
Acute myeloid leukemia
IKBKB; SFPI1; MAP2K2; RPS6KB2; CCNA1; STAT5A; FLT3; MAP2K1; EIF4EBP1; PIK3CA
Small cell lung cancer
IKBKB; LAMC2; LAMA2; ITGA6; BCL2; RXRG; TRAF6; ITGA2; LAMA4; ITGA3
Non-small cell lung cancer
MAP2K1; PRKCG; BAD; PRKCA; PDPK1; RARB; GRB2; AKT1; FOXO3; RASSF1
Central carbon metabolism in cancer
PIK3R3; NTRK1; MAPK3; AKT1; KRAS; PDGFRB; PIK3CD; SIRT3; FLT3; PGAM2
Choline metabolism in cancer
SLC44A1; DGKZ; MTOR; PRKCA; PLA2G4B; PRKCG; MAPK3; PLA2G4C; PIK3R5; SP1

Protein Function

PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3C2B; PIK3CB; PIK3C3; PIK3CA; PIK3R3; PIK3CG; PIK3C2A; PIK3C2G; ATM; PIK3CD
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3C2B; PIK3CD; PIK3C2A; PIK3CB; PIK3C2G; PIK3CG; PIK3CA
Function ATP binding
Related Protein FYNA; PSMC6; SNRNP200; CLK2B; NTRK2; SMARCA5; MYH4; ATP9A; FARSB; XRCC6
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CG; PIK3C2A; PIK3CD; PIK3CB; PIK3CA
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CA; PIK3CD; PIK3CB; PIK3CG
Function protein binding
Related Protein STK4; CACNA2D1A; LAPTM5; RBFA; TXNDC5; RTKN; BMPR1A; ZNF559-ZNF177; DDX41; POLR1A

Interacting Protein

PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.
PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY