pik3cd
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  • Official Full Name
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
  • Background
  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
  • Synonyms
  • PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
Cat.#:PIK3CD-1896HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged
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Cat.#:PIK3CD-1727HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3CD protein, His & T7-tagged
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Cat.#:PIK3CD-29587THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD
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Cat.#:PIK3CD-52HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CD, GST-tagged
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Cat.#:PIK3CD-1989CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CD
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Cat.#:PIK3CD-11416ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3CD
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Cat.#:PIK3CD-3187HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD 293 Cell Lysate
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Involved Pathway

PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PIK3C2B; MTMR6; INPP5A; ITPKC; MTMR7B; CDIPT; IMPA1; INPPL1A; MIOX; PLCH2
ErbB signaling pathway
HRASA; RAF1A; TGFA; MAPK8A; CBLC; HRASB; CDKN1BB; ERBB4A; PTK2; MAP2K4B
Ras signaling pathway
FGF11; PAK3; MAPK8; REL; GNB2; RASA1; ABL1; INS1; RALBP1; ARF6
Rap signaling pathway
FGF5; SIPA1L1; FIGF; CDH1; ITGB2L; PDGFRB; KLK1B4; INS; PIK3CG; RASGRP3
cGMP-PKG signaling pathway
GTF2I; NPPB; PLCB3; CREB3L1; MAP2K1; CREB5; MYLK3; IRS4; NFATC2; PPP3R2
cAMP signaling pathway
RAP1B; CAMK4; HTR4; FSHB; VAV2; CREB5; CNGA1; LIPE; ATP2B1; ACOX1
Chemokine signaling pathway
CCL4L2; PIK3R3; PLCB1; GNG4; GRK4; CXCL12; CCR1; CCL13; HCK; RAP1A
HIF- signaling pathway
RBX1; RPS6; IGF1R; MAP2K1; LTBR; HK1; Trf; FLT1; BCL2; ENO2
FoxO signaling pathway
FOXO1; CCNB2; INSRA; AGAP2; HOMER3; NLK1; CAT; GRB2; SOS1; PRKAB1A
Phosphatidylinositol signaling system
IPMK; PLCD1A; MTMR1A; PIK3C2G; PIP4K2B; CALM4; PIK3C3; INPP4A; PLCB4; PPIP5K2
Sphingolipid signaling pathway
PIK3CA; PPP2R3A; SPTLC1; PIK3CD; PPP2R1A; PPP2R2A; ROCK1; PTEN; FCER1G; SMPD2
Phospholipase D signaling pathway
RAF1; GRM6; SHC2; RALB; Adcy4; AVP; RHOA; PTK2B; MTOR; AGTR1B
mTOR signaling pathway
TSC1; STRADA; VEGFAA; DDIT4; RPS6KA2; PRKCG; INS1; RPS6KB1; ULK1; CAB39L1
PIK-Akt signaling pathway
IBSP; IL3; IL2RG; CCND1; INSR; Gh; GNG12; CCND2; EPO; CASP9
AMPK signaling pathway
CREB3; IGF1; RAB10; RHEB; PFKL; LEP; PPP2R2D; CFTR; PPP2R2B; MTOR
Apoptosis
Gzmg; Fasl; BIRC2; BAD; BOK; CASP12; TP53; CFLARA; PIK3R2; PLECA
Adrenergic signaling in cardiomyocytes
MAPK14A; CACNG8; MYL2B; ATF6B; GNA11A; FXYD2; TPMA; CACNG2A; CALM2B; ADRA1BB
VEGF signaling pathway
NFATC2; PTGS2; PLA2G4A; SHC2; MAPK1; MAP2K1; PTK2AA; PLA2G4C; RAC1B; RAC1A
Osteoclast differentiation
FCGR1A; TGFB1; LCK; FYN; PIK3CD; PIK3R5; PIK3R3; PPP3CA; cgr2b; TRAF2
Focal adhesion
PIK3CG; ITGA11A; RHOAD; PIK3CB; PAK2A; COL1A1; RAF1; VEGFA; IGF1; VAV2
Signaling pathways regulating pluripotency of stem cells
FZD6; WNT8A; APC; PCGF1; SKIL; WNT7B; TCF3; SMAD2; ACVR1C; INHBE
Platelet activation
PTGS1; VWF; MAPK12; PIK3R1; COL24A1; BTK; SNAP23; FERMT3; MYL12B; MYL12A
Toll-like receptor signaling pathway
MAPK12A; IFNPHI1; TLR4BB; MAPK12B; PIK3R2; AKT1; IL8L2; CD86; RAC1A; STAT1B
Jak-STAT signaling pathway
LEP; STAT5B; IL15RA; IL11RA; LEPB; STAT1; AKT1; LIF; IL23; IL6
Natural killer cell mediated cytotoxicity
KIR2DL3; KLRA8; IFNAR1; GRB2; SH3BP2; NCR3; KIR2DS5; IFNA6; PPP3CC; IFNG
T cell receptor signaling pathway
PIK3R3; CARD11; PAK3; NCK2; IKBKB; MAP2K1; IFNG; PAK1; VAV3; TEC
B cell receptor signaling pathway
IKBKG; RAF1; PIK3R3; IFITM1; LYN; PDPK1A; ITPR2; GRB2; SLA2; LIME1
Fc epsilon RI signaling pathway
PIK3CA; VAV3; PIK3R2; PIK3R5; PLCG1; IL5; FCER1G; PIK3R3; RAC3; MAPK3
Fc gamma R-mediated phagocytosis
MYO10; PIK3CG; LIMK2; PIK3R1; PRKCG; PIP5K1C; MAPK3; FCGR1; PPAP2B; SPHK1
TNF signaling pathway
FAS; VCAM1; CXCL2; RIPK1; ITCH; LIF; CCL2; TRADD; AKT1; FADD
Leukocyte transendothelial migration
PIK3CB; CLDN2; MYL12B; CLDN9; ESAM; PIK3CA; CLDN15; ACTN2; BCAR1; RAC1
Neurotrophin signaling pathway
CALML5; RHOA; SH2B2; SORT1; NFKBIE; MATK; PIK3R1; ATF4; IRAK2; MAPK8
Cholinergic synapse
KCNJ4; PIK3R2; CAMK2G; JAK2; CHRNB4; MAPK3; GNG4; PLCB2; GNAI3; KCNJ2
Inflammatory mediator regulation of TRP channels
CALML5; PRKCQ; TRPV1; PLCB1; CYP2J2; PRKCE; NTRK1; PIK3CD; TRPV3; CYP4A14
Regulation of actin cytoskeleton
FGF22; PIKFYVE; INS; ARHGAP35; MYL2; SRC; DIAP1; FGFR2; MYH10; RRAS2
Insulin signaling pathway
PPP1CA; CALM3; FLOT2B; PRKAR2AA; INPPL1A; PRKAA1; PTPN1; CALM2B; PPP1R3CB; PRKACA
Progesterone-mediated oocyte maturation
PKMYT1; HSP90AA1.1; CDC25A; CPEB2; CCNA1; CDC26; AKT3A; PIK3R3A; PIK3CB; ADCY1B
Estrogen signaling pathway
PLCB4; HSPA6; CALML3; PIK3R3; CALM3; ESR2; GABBR1; PLCB2; HRAS; HSP90B1
Prolactin signaling pathway
INS; SOCS1; GRB2; NEK3; TNFSF11; STAT5B; GSK3B; INS2; TH; FOXO3
Thyroid hormone signaling pathway
KRAS; SLC16A2; MAPK1; PRKCB; ACTB; CCND1; DIO2; PDPK1; SLC16A10; PIK3R3
Oxytocin signaling pathway
MAPK3; CALM2; PPP1CC; OXT; PRKAA2; CAMKK2; RYR1; ROCK1; PLCB2; PIK3R1
Regulation of lipolysis in adipocytes
GNAI1; INS1; GNAI2; TSHR; IRS1; NPY1R; PNPLA2; PTGER3; AKT2; TSHB
Type II diabetes mellitus
MAPK10; INS-IGF2; PRKCZ; SLC2A2; PIK3CD; PRKCE; MAPK9; HKDC1; MAPK1; HK2
Insulin resistance
RPS6KA1; PIK3CG; PTPRF; RPS6KA6; AKT2; GFPT2; RPS6KA3A; SOCS3; G6PC3; PPARGC1B
Non-alcoholic fatty liver disease (NAFLD)
COX6B2; FASLG; NDUFS7; ATF4; IL1A; BAX; IKBKB; COX7B2; PPARA; NDUFC2-KCTD14
Aldosterone-regulated sodium reabsorption
SGK1; PRKCB; ATP1B1; HSD11B2; PIK3R5; INS2; ATP1A2; SLC9A3R2; ATP1A3; ATP1A4
Carbohydrate digestion and absorption
AMY2B; SLC2A2; PIK3R1; SLC5A1; ATP1B3; AMY2A4; G6PC; PIK3R5; Amy1; GNAT3
Bacterial invasion of epithelial cells
CAV1; DNM3; WAS; ARPC5; ARPC2; WASF2; RHOG; CDC42; VCL; ELMO3
Chagas disease (American trypanosomiasis)
NFKBIA; TLR2; ACE; PIK3R2; C1QA; IL12B; IL1B; PIK3R1; IFNB1; C3
Toxoplasmosis
BIRC2; LAMC2; HLA-DRA; RELA; HLA-DQB1; MAP2K6; TGFB3; BIRC3; HLA-DRB4; IL10RA
Amoebiasis
CD14; PLCB2; CXCL8; C8G; LAMC3; SERPINB1C; SERPINB4; ITGAM; RAB7A; NOS2
Hepatitis C
IFNB1; PPP2CA; TRAF3; TP53; BAD; PPP2R2A; RIPK1; PDPK1; CLDN17; IFNA14
Hepatitis B
DDX58; IFNA21; CASP9; MAVS; ELK1; PIK3CD; STAT6; IKBKB; IL6; SMAD3
Measles
TNFRSF10A; Ifna11; IFNGR1; IL2RB; IL12B; EIF2AK4; EIF2AK1; PIK3R2; TNFRSF10C; IRF7
Influenza A
STAT2; IL12B; HLA-DOB; EP300; OAS1; IRF3; PRSS2; ACTG1; IKBKB; IFNA12
HTLV-I infection
MYBL2; ITGB2; ATF1; MRAS; CDC16; HLA-DMB; HLA-DQA2; ANAPC4; KAT2A; HLA-DRB5
Epstein-Barr virus infection
EIF2AK2; MAP2K4; GTF2E2; PSMD11; HLA-DRA; POLR1C; NCOR2; HLA-E; PSMD4; SND1
Pathways in cancer
RAC2; TP53; TRAF2; LAMB3; DAPK1; WNT3A; LAMB4; ABL1; LAMA2; Adcy4
Viral carcinogenesis
DDX3X; RHOA; HLA-E; HDAC7A; CCNA2; CCND1; DLG1; YWHAG; HIST1H2BH; SYK
Proteoglycans in cancer
MAP2K2; CBL; FLNC; PLCG1; RPS6; PPP1CC; PPP1R12C; ANK1; TLR2; IL12B
Colorectal cancer
RAC3; SMAD3; PIK3CA; MSH2; BIRC5; RAF1; MAP2K1; APC; MAPK9; CASP9
Renal cell carcinoma
TGFA; ARAF; EPAS1; TCEB2; FLCN; EP300; AKT2; RAC1; PIK3CA; MAP2K2
Pancreatic cancer
RAC3; PIK3CG; TGFBR2; NFKB1; CCND1; SMAD2; STAT3; AKT1; AKT2; ERBB2
Endometrial cancer
AXIN1; BRAF; PTEN; APC; MAP2K2; PIK3R5; MLH1; GSK3B; AXIN2; ELK1
Glioma
PIK3CG; RAF1; AKT1; PRKCG; SHC2; BRAF; IGF1; IGF1R; PIK3R3; PIK3CD
Prostate cancer
TP53; AKT1; ERBB2; FOXA1; IGF1; BRAF; MAPK3; RB1; PIK3R2; PDGFC
Melanoma
MDM2; PIK3CG; NRAS; PIK3R1; TRP53; FGF16; FGF13; FGF11; FGF1; PDGFD
Chronic myeloid leukemia
SMAD4; SHC4; PIK3R1; KRAS; CRKL; MAPK1; GRB2; SHC3; SHC2; IKBKB
Acute myeloid leukemia
PIK3CG; RUNX1T1; STAT5B; BRAF; AKT3; MAP2K1; PIK3R2; AKT1; PIK3R5; CCNA1
Small cell lung cancer
BIRC3; AKT1; PIK3R2; PIK3CG; LAMA4; PIK3R1; LAMA3; TRAF6; LAMC1; PIK3R5
Non-small cell lung cancer
FHIT; TGFA; KRAS; RB1; AKT2; CASP9; RXRB; PLCG2; PIK3R5; PLCG1
Central carbon metabolism in cancer
FGFR2; HK2; SLC2A2; SLC7A5; C12orf5; PDGFRB; PIK3CG; PGAM2; PKM; PTEN
Choline metabolism in cancer
PDGFRB; PIP5K1A; MTOR; DGKG; RPS6KB1; PIK3CD; PIP5K1C; PIP5K1B; PLA2G4C; WASF3

Protein Function

PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3CB; PIK3C3; PIK3R3; PIK3C2A; ATM; PIK3CD; PIK3C2B; PIK3C2G; PIK3CG; PIK3CA
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3CA; PIK3C2G; PIK3CD; PIK3C2B; PIK3CB; PIK3CG; PIK3C2A
Function ATP binding
Related Protein HSP90AA1.1; TPK1; SGK1; P2RX2; IARS2; NUAK2; GLUD1; DCLK2; ABCC3; PFKP
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CA; PIK3CD; PIK3CB; PIK3CG; PIK3C2A
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CG; PIK3CD; PIK3CA; PIK3CB
Function protein binding
Related Protein ZNF426; SWAP70; EXOSC3; ZNF202; TFIP11; C19orf47; ASAP2; PSMG1; H2AFY; SSH1

Interacting Protein

PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.
PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY