pik3cd
Share
  • Official Full Name
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
  • Background
  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
  • Synonyms
  • PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
Cat.#:PIK3CD-1896HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged
+Inquiry
Cat.#:PIK3CD-1727HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3CD protein, His & T7-tagged
+Inquiry
Cat.#:PIK3CD-29587THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD
+Inquiry
Cat.#:PIK3CD-52HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CD, GST-tagged
+Inquiry
Cat.#:PIK3CD-1989CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CD
+Inquiry
Cat.#:PIK3CD-11416ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3CD
+Inquiry
Cat.#:PIK3CD-3187HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD 293 Cell Lysate
+Inquiry

Involved Pathway

PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
ITPKC; INPPL1A; MINPP1; PIP5KL1; IPMK; IPPK; NUDT4; MINPP1B; INPP5L; PI4K2A
ErbB signaling pathway
PAK6B; NCK2; ABL2; PLCG1; HRAS; MTOR; SOS1; PAK7; BADB; KRAS
Ras signaling pathway
ABL2; RASGRP3; BRAP; VEGFC; MAP2K1; ANGPT4; PRKACA; PLA2G2A; GNG10; MAPK10
Rap signaling pathway
PLCE1; KLK1B4; NRAS; PDGFA; MET; RAC2; KIT; ANGPT2; LCP2; RAC3
cGMP-PKG signaling pathway
INS; CREB5; NFATC1; GTF2I; NFATC3; PDE3A; CALML5; ATP1A4; CALM3; PIK3CB
cAMP signaling pathway
FFAR2; CREB3L3; TSHR; VAV2; GLP1R; RAC1; ATP2A2; HCN4; PDE4C; CALM2
Chemokine signaling pathway
CXCL5; GNG13; VAV2; SOS1; JAK3; GRK6; CCL23; GRK1; HCK; Ccl21c
HIF- signaling pathway
NOS2; RPS6KB1; PIK3R5; PRKCA; PIK3CB; ENO1; PFKFB3; HKDC1; NOX1; PIK3R1
FoxO signaling pathway
PIK3R3B; INSRA; PRKAG1; TGFBR1; G6PC3; PDPK1; CDKN2B; PRKAG2; MDM2; MAP2K2
Phosphatidylinositol signaling system
IPPK; CALM3B; INPPL1A; INPP5A; TMEM55A; PLCB4; IMPA2; PRKCG; PPIP5K2; PIP5K1A
Sphingolipid signaling pathway
LOC100328615; TNF; MS4A2; PIK3CB; PLD2; NRAS; PTEN; MAPK1; PLCB4; ASAH1
Phospholipase D signaling pathway
FCER1G; PIP5K1B; F2R; CYTH2; RALGDS; PIK3R5; FYN; MAP2K1; RHEB; AGPAT4
mTOR signaling pathway
VEGFAA; PDPK1B; POLDIP3; PRKCG; MLST8; RRN3; RRAGCB; CAB39L; TNF; PIK3CB
PIK-Akt signaling pathway
GNG12; FGF19; CD19; Il6ra; LAMC2; GNG4; FGF14; ATF4; Gh; CCND3
AMPK signaling pathway
PPP2R2B; PPP2R2C; PRKAB2; FOXO3; PRKAA1; SLC2A4; PPP2R5D; CREB3L4; ELAVL1; STK11
Apoptosis
IKBKG; PLEC; TRP53; IKBKB; BIRC3; HDR; PRKAR1B; PRKACG; IRF4A; NMT1
Adrenergic signaling in cardiomyocytes
PPP2R2D; CACNG2A; PRKACAA; CACNB3A; PPP1CC; ATP2B3B; CREB3; VMHCL; TPM4A; RAPGEF3
VEGF signaling pathway
PRKCG; PIK3CD; RAC1B; SPHK1; PRKCA; RAF1B; NFATC2; PLA2G4D; HRAS; NOS3
Osteoclast differentiation
OSCAR; FCGR1; NFATC1; FHL2; cgr2b; TNFRSF11A; MAPK12; PPP3CB; IFNAR1; SOCS3
Focal adhesion
RAP1AA; THBS4; PTENA; FLT4; PDPK1; MAPK8B; PPP1CBL; VAV3B; COL1A1A; THBS3
Signaling pathways regulating pluripotency of stem cells
FZD6; SKIL; PCGF6; MYF5; FZD5; PCGF2; ESX1; JARID2; ACVR1C; IGF1
Platelet activation
MYL12A; FERMT3; NOS3; ARHGEF1; GUCY1A3; ROCK2; GP1BA; GUCY1B3; ITGB1; RAP1A
Toll-like receptor signaling pathway
IL-8; TLR4BB; AKT1; MAPK8A; IKBKB; RAC1A; TOLLIP; CD80; FADD; TLR1LB
Jak-STAT signaling pathway
PIM1; FHL1; PIK3CD; IL23; RAF1A; IL10RB; IRX1; IL20RB; AOX2P; STAT4
Natural killer cell mediated cytotoxicity
PRF1; KLRC4-KLRK1; PRKCB; KLRC1; PTPN6; FASLG; KLRC2; FCGR3B; IFNA2; SH3BP2
T cell receptor signaling pathway
MAPK12; SLA1; MUC1; MAPK1; LAT; RHOA; NFKB1; TEC; CD8B; HRAS
B cell receptor signaling pathway
CR2; LYN; RELA; TTC6; MAPK4; CDK4; PIK3CB; ITPR2; SYK; MAPK3
Fc epsilon RI signaling pathway
PIK3CG; MAP2K2; AKT2; KRAS; PIK3R5; IL4; MAP2K6; LYN; PLA2G4B; GM-CSF
Fc gamma R-mediated phagocytosis
MAP2K1; PIK3CB; LIMK1; SPHK1; PPAP2A; BIN1; PRKCA; WAS; PLD1; VAV1
TNF signaling pathway
MAPK1; PGAM5; MAP2K1; MAPK13; CFLAR; TRAF3; MAPK11; CXCL3; RELA; IKBKB
Leukocyte transendothelial migration
ITGB2; RAC1; CLDN1; ARHGAP35; CYBB; TXK; CLDN23; ACTN1; ITGB2L; CLDN16
Neurotrophin signaling pathway
TP53; MAP2K2; MAGED1; RAP1B; PDPK1; MAPK10; ZNF274; MAP2K5; SHC2; NTF4
Cholinergic synapse
GNAI1; CREB3L2; FYN; CAMK4; PLCB4; GNG7; MAPK1; CHRM2; CHAT; GNGT2
Inflammatory mediator regulation of TRP channels
HTR2A; MAP2K6; ASIC1; NGF; ALOX12; TRPV4; PLA2G6; PIK3CG; PRKCB; PIK3CB
Regulation of actin cytoskeleton
CDC42L2; FGF18; MYL2B; MYL12.1; PDGFAA; FGF4; PAK6; ARHGEF12; PDGFD; INSRR
Insulin signaling pathway
PRKACBA; PRKAR2AA; FBP1B; FOXO1; G6PC2; PIK3R3B; HRASB; MKNK2A; PHKG2; INPPL1
Progesterone-mediated oocyte maturation
FZR1; PIK3R5; CCNB1; MAD2L2; MAPK8B; ADCY1A; ADCY2B; CPEB2; CDC27; RPS6KA3
Estrogen signaling pathway
PRKCD; Adcy4; CALM3; PLCB2; SHC1; PIK3CG; HSP90B1; HSPA1B; AKT2; SHC3
Prolactin signaling pathway
SHC2; LHB; SOCS1; MAPK3; SOCS5; RELA; CCND1; MAPK1; AKT2; SOS1
Thyroid hormone signaling pathway
MTOR; TBC1D4; PLCG2; MED27; MED4; KAT2B; MED17; PIK3R3; TRP53; PLCB4
Oxytocin signaling pathway
GUCY1A3; CAMK4; GNAO1; PIK3CB; MYLK4; Adcy4; PPP1R12A; PTGS2; NPR1; PIK3R1
Regulation of lipolysis in adipocytes
LIPE; LOC100328615; PTGS2; PIK3R5; GNAI2; PIK3R2; AQP7; PDE3B; PIK3CB; INS2
Type II diabetes mellitus
HKDC1; PIK3R2; PIK3CG; SLC2A4; PIK3CD; MTOR; PRKCZ; PIK3R3; PKLR; PIK3CB
Insulin resistance
FOXO1B; PIK3R3B; TNF; MAPK8B; RPS6KB1B; PDPK1B; PIK3R1; STAT3; PCK1; PDPK1
Non-alcoholic fatty liver disease (NAFLD)
NDUFB2; SDHC; NDUFA10; NDUFB9; MAP3K11; IRS2; Fasl; AKT2; PIK3CB; UQCR10
Aldosterone-regulated sodium reabsorption
ATP1A4; FXYD4; IGF1; PIK3R5; FXYD2; SFN; MAPK1; PIK3CD; KCNJ1; PRKCA
Carbohydrate digestion and absorption
PIK3R3; FXYD2; HK1; AKT1; SLC37A4; PIK3R2; ATP1A4; AMY2A5; PIK3CG; SLC2A2
Bacterial invasion of epithelial cells
PIK3CB; WASF1; SEPT11; SEPT2; WAS; ARPC5; ARPC1B; ACTB; SHC2; CTNNA1
Chagas disease (American trypanosomiasis)
PIK3R1; PIK3R2; SMAD2; AKT1; CALR; PPP2R2B; CCL3L1; PPP2R1B; CCL2; TGFB2
Toxoplasmosis
HLA-DOA; GNAI1; ITGA6; IRGM; HSPA8; XIAP; Toxoplasma Gondii Major Surface Antigen P30; Toxoplasma Gondii Microneme Protein MIC3; PIK3R5; PIK3R3
Amoebiasis
PLCB3; CD1d1; LAMA5; PLCB4; RAB5B; COL4A6; PRKACB; COL5A1; COL2A1; CD14
Hepatitis C
IKBKG; PIK3R3; MAPK1; IFNA21; IKBKB; CLDN15; TRP53; IFNB1; PIK3CD; TBK1
Hepatitis B
PIK3R2; MAPK8; IFNA4; MAPK3; RAF1; PRKCA; CCNE2; MAP3K1; CASP12; MAP2K1
Measles
Ifna11; TLR9; TRP53; TLR4; IRAK1; PRKCQ; CCNE2; DOK1; TLR7; MX1
Influenza A
PABPN1; IFNA2; HLA-DRB3; IFNA3; IFNA6; IL1A; EIF2AK3; OAS1; IFNA4; NXF1
HTLV-I infection
LCK; PTTG1; RELB; NFATC2; WNT3; PDGFA; ELK4; KAT2A; RRAS; ANAPC1
Epstein-Barr virus infection
POLR2D; MAPK8; HLA-DPB1; PSMD11; IKBKG; YWHAG; POLR3G; TRP53; RELB; CD38
Pathways in cancer
TGFBR1; FZD7; GNAS; GNG10; FOS; CBL; TGFBR2; AGTR1A; CASP8; WNT9B
Viral carcinogenesis
HIST1H4N; NFKB1; TRAF1; KRAS; HIST1H2BF; BAD; HDAC3; HIST1H2BI; GTF2A1L; CCND3
Proteoglycans in cancer
WNT3A; FGFR1; NRAS; FZD6; TIMP3; RRAS; PLCG2; PIK3CD; HCLS1; WNT6
Colorectal cancer
KRAS; MAPK1; AKT1; TRP53; RHOA; GSK3B; AKT2; MAPK9; PIK3R5; TGFB1
Renal cell carcinoma
AHA-1; AKT2; SLC2A1; PAK3; PTPN11; FH1; AKT1; MAP2K1; SOS1; MAP2K2
Pancreatic cancer
TGFB3; VEGFA; BAD; PIK3R1; RALB; NFKB1; SMAD2; TGFBR1; RAD51; TGFBR2
Endometrial cancer
KRAS; BRAF; PIK3CA; LEF1; TRP53; APC2; GRB2; MLH1; CASP9; ILK
Glioma
NRAS; AKT1; SHC1; RB1; SHC3; SHC2; PRKCA; PIK3CA; TP53; PLCG1
Prostate cancer
RAF1; ARAF; BRAF; MAPK3; FOXO1; ATF4; PIK3R2; FGFR1; NDRG1; NFKBIA
Melanoma
RB1; MAP2K1; FGF18; PDGFRA; PIK3R5; CCND1; FGFR1; FGF16; AKT1; PDGFRB
Chronic myeloid leukemia
PIK3R1; IKBKB; SOS1; GAB2; HRAS; TGFBR2; SMAD4; RAF1; ABL1; AKT1
Acute myeloid leukemia
STAT5A; STAT3; PIK3R2; EIF4EBP1; KIT; RUNX1; MAPK1; SPI1; CEBPA; CCND1
Small cell lung cancer
ITGAV; XIAP; PIK3CA; LAMA4; CASP9; BIRC7; TP53; LAMA3; BIRC2; FN1
Non-small cell lung cancer
PRKCA; MAPK1; BRAF; PRKCG; RXRA; FOXO3; TP53; PIK3CA; HRAS; EML4
Central carbon metabolism in cancer
ERBB2; PIK3CA; PDGFRB; PKM; SIRT6; RET; PGAM1; RAF1; HKDC1; NRAS
Choline metabolism in cancer
MAPK3; SLC44A1; SP1; PLA2G4C; RAF1; PDGFRA; RALGDS; MAPK10; SLC44A2; PLA2G4F

Protein Function

PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R3; PIK3C3; ATM; PIK3C2G; PIK3CA; PIK3CG; PIK3C2B; PIK3CD; PIK3C2A; PIK3CB
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3CG; PIK3C2A; PIK3C2G; PIK3CA; PIK3C2B; PIK3CB; PIK3CD
Function ATP binding
Related Protein NLRP12; ITPKB; AK3; DDX6; PIP5K1B; NADK; RECQL5; KIF7; CARKD; KIF15
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CB; PIK3CG; PIK3CA; PIK3CD; PIK3C2A
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CA; PIK3CB; PIK3CG; PIK3CD
Function protein binding
Related Protein PINX1; SCGB2A2; RBL2; SPIN1; SLC30A8; LTC4S; LIG4; IRF2; POC1B; NAA30

Interacting Protein

PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.
PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY