pik3cd
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  • Official Full Name
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
  • Background
  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
  • Synonyms
  • PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
Cat.#:PIK3CD-1896HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged
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Cat.#:PIK3CD-1727HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3CD protein, His & T7-tagged
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Cat.#:PIK3CD-29587THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD
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Cat.#:PIK3CD-52HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CD, GST-tagged
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Cat.#:PIK3CD-1989CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CD
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Cat.#:PIK3CD-11416ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3CD
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Cat.#:PIK3CD-3187HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3CD 293 Cell Lysate
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Involved Pathway

PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
TPI1B; INPP4A; PIK3CA; MTMR1B; PIK3C3; PIP5K2; NUDT4B; PLCB1; SYNJ2; PIP5K1C
ErbB signaling pathway
MAP2K4; ABL2; AREGB; RPS6KB2; MAPK8; MAPK8B; GSK3B; PAK2B; SHC4; SOS1
Ras signaling pathway
FGFR2; ABL2; MAP2K1; GRIN2B; RIN1; MLLT4; RAPGEF5; FGF12; RGL2; MAPK8
Rap signaling pathway
PGF; VAV2; RAC2; PIK3R1; FGF19; IGF1; LPAR5; ITGB3; RAC3; FGF8
cGMP-PKG signaling pathway
PDE2A; CALM4; INS1; VASP; PLCB1; NFATC4; RGS2; BDKRB2; MYLK4; NPPB
cAMP signaling pathway
VAV3; ATP1B2; RAC1; GRIN3B; GNAI1; PIK3R3; GNAI2; PIK3R5; RAF1; CREB3L3
Chemokine signaling pathway
GSK3A; GNB4; CXCL12; CCL17; CCL21B; CXCL8; GNG11; WAS; RAC1; GNAI2
HIF- signaling pathway
EPO; ENO2; PDHA2; TIMP1; EP300; ENO1; PDHB; TCEB1; IFNGR2; HKDC1
FoxO signaling pathway
PIK3R3; IGF1; GADD45B; G6PCA.2; TGFB1; PIK3R1; RAF1A; SOD2; MAPK3; SLC2A4
Phosphatidylinositol signaling system
IPMKB; PIK3C3; PIP5K1A; PLCE1; PLCB1; PTENA; PLCD3A; CDS2; MTMR3; IPPK
Sphingolipid signaling pathway
MAPK9; TNFRSF1A; PLD2; GNAI3; KRAS; AKT2; PIK3R3; PIK3CB; PIK3R5; BDKRB2
Phospholipase D signaling pathway
Adcy4; PLD2; DGKE; AGPAT3; PLCG1; ARF6; GRM1; PLA2G4D; AGTR1A; INSR
mTOR signaling pathway
DEPDC6; TSC1B; PDPK1B; PIK3R2; DDIT4; PIK3CA; TSC1A; PTEN; ULK3; TSC2
PIK-Akt signaling pathway
ITGA7; FGF18; Itga10&Itgb1; TP53; ITGA9; LPAR2; PDGFD; BCL2; THBS2; GH2
AMPK signaling pathway
INSR; AKT1; PPP2R2D; PPP2R3A; G6PC; PIK3CG; PFKFB3; PPP2R2C; CAMKK1; CPT1C
Apoptosis
BAXB; PRKACB; GZME; IRF4A; DIABLOA; PRKACBA; PRKAR2B; PLECA; Casp3; BMX
Adrenergic signaling in cardiomyocytes
TMEM8C; CACNG2; PIK3CA; ATP1B3A; CALM2B; PIK3R2; ADRA1B; ADCY2B; CALM3; PRKACA
VEGF signaling pathway
PPP3R2; NFATC2; RAC1B; PTGS2B; PLCG1; PXN; PLCG2; PIK3R3; SHC2; RAC1
Osteoclast differentiation
MAPK10; TGFBR1; PPARG; FCGR3; SIRPB1; LILRB1; FCGR1; IFNGR1; PIK3R1; FCGR3A
Focal adhesion
PAK2; ACTB1; COL6A2; PDPK1; DOCK1; RAF1; AASS; Itga10&Itgb1; COL27A1A; FYNA
Signaling pathways regulating pluripotency of stem cells
JARID2; WNT10B; SMAD2; IGF1R; BMI1; FGFR3; WNT2B; OTX1; ESRRB; ACVR2A
Platelet activation
MYL12A; MYLK3; COL27A1; GNAQ; PRKCI; SRC; PLA2G4F; ARHGEF1; GP9; F2RL3
Toll-like receptor signaling pathway
MAP2K4A; MAPK13; TMED7-TICAM2; TICAM2; CD86; MAPK11; PIK3CB; MAP2K2A; MAPK12; PIK3CG
Jak-STAT signaling pathway
STAT1; IL7; HRASB; IL13RA1; IFNA1; BCL2; IL20RB; MCL1; NT5C3; HRASA
Natural killer cell mediated cytotoxicity
RAET1G; IFNA2; ULBP2; BRAF; H60a; PIK3R5; KIR2DS4; FCGR3; Fasl; SAMD3
T cell receptor signaling pathway
CD3E; CD3D; PIK3R3; MAP2K1; MAP2K7; PPP3R1; MAPK3; PAK2; VAV1; PRKCQ; TEC
B cell receptor signaling pathway
DUSP4; NFKB1; CD79B; IGHM; HRAS; CDK2; PIK3CB; CDK4; DUSP6; CRK
Fc epsilon RI signaling pathway
MAPK10; BTK; LYN; GAB2; VAV2; LAT; MAP2K7; PIK3CD; MAPK8; INPP5D
Fc gamma R-mediated phagocytosis
PIP5K1A; ARF6; ASAP2; FCGR1; CDC42; PPAP2B; WASF3; ARPC1A; MARCKSL1; SPHK2
TNF signaling pathway
TRAF3; ATF4; MAPK1; CREB3L1; CXCL1; AKT2; MAP3K7IP3; CASP7; TRADD; MAP2K7
Leukocyte transendothelial migration
THY1; VAV3; ARHGAP35; AASS; RAC1; MYL10; CLDN7; MMP2; GNAI2; CLDN8
Neurotrophin signaling pathway
ARHGDIB; NTF3; MAPK3; FOXO3; CAMK2B; RPS6KA6; BRAF; PIK3CG; SHC3; NTF4
Cholinergic synapse
GNAO1; CHRM3; CREB5; ATF4; CHRM1; GNG12; CHRNB4; PIK3R3; AKT2; FOS
Inflammatory mediator regulation of TRP channels
CAMK2B; PLCB4; MAP2K6; PLA2G4A; CAMK2A; CYP2C55; PLA2G4D; ASIC5; ALOX12; CYP2J5
Regulation of actin cytoskeleton
FGF8; PDGFRB; Itgam&Itgb2; SSH1; RAF1A; MYL9A; ITGA9; VAV2; MYL12.2; VAV3
Insulin signaling pathway
PDE3B; SLC2A4; PPP1R3A; EIF4EA; EIF4E2RS1; TRIP10; SOS1; SOCS9; PPP1CAB; EXOC7
Progesterone-mediated oocyte maturation
BRAF; ARAF; MAPK13; ANAPC2; SPDYB; MAPK11; MAPK12A; RPS6KA6; PPP1R2P9; AKT1
Estrogen signaling pathway
PIK3R3; HSPA6; HRAS; GNAI2; CALM3; SHC1; FKBP4; PRKACB; PLCB4; PLCB2
Prolactin signaling pathway
SOS1; SOCS5; AKT1; PIK3CB; KRAS; PRLR; RELA; AKT2; CCND2; MAP2K1
Thyroid hormone signaling pathway
NOTCH3; RCAN1; ACTG1; SLCO1C1; PRKACB; ATP1B2; THRB; PLCB4; ITGAV; PLCG2
Oxytocin signaling pathway
PPP3CC; TRPM2; PPP1R12C; MYLK3; RHOA; PPP3CA; PPP1R12A; OXT; PIK3CD; PLA2G4F
Regulation of lipolysis in adipocytes
AQP7; FABP4; PIK3R1; PIK3R5; PTGER3; PRKACB; AKT2; PRKG2; Adcy4; TSHB
Type II diabetes mellitus
PIK3CB; PIK3R5; MAFA; SOCS4; SOCS2; PKM; MTOR; IKBKB; TNF; INSR
Insulin resistance
IRS2; PRKAB1; INS; MAPK10; RPS6KA3; PPP1CA; CREB5; PIK3R3A; INS1; AKT1
Non-alcoholic fatty liver disease (NAFLD)
NDUFC1; IL6; UQCR10; NDUFS3; ATF4; SOCS3; XBP1; NDUFB8; PPARA; NDUFA11
Aldosterone-regulated sodium reabsorption
SCNN1G; KCNJ1; PRKCG; SLC9A3R2; SFN; PIK3CG; PIK3CA; ATP1A4; SGK1; IRS1
Carbohydrate digestion and absorption
PRKCB; PIK3CB; GNAT3; AMY1A; SLC2A2; ATP1B4; G6PC3; AKT1; PIK3CG; PIK3R5
Bacterial invasion of epithelial cells
CRKL; RAC1; PIK3R2; SHC2; CTTN; DNM1; ACTG1; SEPT1; ARPC4; CD2AP
Chagas disease (American trypanosomiasis)
GNA15; IL1B2; C1QA; PPP2R2A; IFNB1; PLCB4; CD3E; IL1B; PIK3CB; NOS2
Toxoplasmosis
NFKB1; HLA-DRB5; MAP3K7; BAD; MAPK12; IRAK4; PPIF; MAP2K6; PIK3CD; LAMB3
Amoebiasis
HSPB1; PLCB4; AASS; SERPINB3C; LAMB1; ACTN1; IL1R2; COL4A6; GNAQ; GNA11
Hepatitis C
MAPK11; IFNAR1; MAPK3; EIF3E; MAVS; Ifna11; EIF2AK1; PPP2R1B; PPP2R2A; CLDN7
Hepatitis B
CXCL8; MAP2K1; DDX3X; MAPK8; BCL2; MMP9; IFNA4; BAD; CASP10; IFNA13
Measles
IL12B; IFNA6; TLR7; MAP3K7; RCHY1; TRAF6; IFNA13; IL1A; PIK3CB; CBLB
Influenza A
RNASEL; PABPN1L; IL12B; KPNA2; PLG; IFNA2; ICAM1; PRSS2; MAPK13; TNFRSF1A
HTLV-I infection
TLN1; HLA-A; GM-CSF; IL1R1; RB1; XBP1; IL2RG; FZD6; RAN; FZD7
Epstein-Barr virus infection
POLR3G; PTMA; HDAC2; SPI1; POLR3B; SND1; CD58; PSMD3; TAB2; IL10RA
Pathways in cancer
RAF1; FZD10; GNAI1; SLC2A1; Flt3l; BIRC7; SOS1; FGF17; IGF1R; PRKACA
Viral carcinogenesis
TBPL2; HLA-B; KRAS; HIST1H4C; BAX; HDAC4; TRAF3; HIST1H4B; YWHAE; HIST1H4I
Proteoglycans in cancer
RHOA; TNF; WNT5A; RDX; PIK3R5; Fasl; TWIST1; NANOG; FLNA; FLNC
Colorectal cancer
MLH1; PIK3CB; RHOA; PIK3R3; TGFB1; APC2; GSK3B; SMAD3; CASP9; AXIN2
Renal cell carcinoma
PAK1; CUL2; GAB1; PAK6; MAP2K1; HGF; AKT1; SOS1; EPAS1; PDGFB
Pancreatic cancer
MAPK10; ARAF; TGFB3; RB1; AKT1; ARHGEF6; RAC2; PIK3R3; PIK3R5; TGFA
Endometrial cancer
FOXO3; CASP9; APC2; PIK3R3; ARAF; GRB2; PIK3R5; TCF7L2; TCF7; AXIN1
Glioma
CALML5; CAMK2A; PIK3CA; PIK3R1; RB1; SHC1; CALML3; GRB2; ARAF; MAPK1
Prostate cancer
PDGFA; BRAF; SOS1; GSK3B; PIK3CA; CASP9; SPINK1; BCL2; RAF1; PDGFB
Melanoma
FGF5; MDM2; MET; RAF1; HRAS; PDGFC; PDGFD; MAP2K2; CDH1; FGF1
Chronic myeloid leukemia
CRKL; GAB2; PIK3R1; TGFB1; HDAC1; MAPK1; MECOM; CDK6; CBLC; SHC4
Acute myeloid leukemia
PIM2; BRAF; SFPI1; PPARD; ARAF; PIK3R1; RPS6KB2; AKT3; NFKB1; PIK3CG
Small cell lung cancer
TRAF2; IKBKB; BIRC7; TRAF1; SKP2; TRAF5; ITGA2; RXRB; PIK3R2; TRP53
Non-small cell lung cancer
ERBB2; MAP2K1; PIK3R2; BAD; PRKCB; KRAS; PRKCG; RASSF1; FOXO3; ALK
Central carbon metabolism in cancer
PIK3R3; SCO2; PKM2; HKDC1; FGFR3; HRAS; PKM; TRP53; C12orf5; AKT2
Choline metabolism in cancer
WASF2; DGKE; SLC22A1; PIP5K1A; TAE1; RALGDS; KRAS; PCYT1A; PPAP2B; PPAP2C

Protein Function

PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein ATM; PIK3CD; PIK3CB; PIK3R3; PIK3C3; PIK3CG; PIK3C2G; PIK3C2A; PIK3C2B; PIK3CA
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3C2B; PIK3C2A; PIK3C2G; PIK3CB; PIK3CG; PIK3CA; PIK3CD
Function ATP binding
Related Protein ABCC11; RAD51B; UBE2S; HSP90AA1.1; RUNX2B; SEPHS1; EIF4A1A; SARS2; IRAK1; ABCA6
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CD; PIK3CG; PIK3CB; PIK3CA; PIK3C2A
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CD; PIK3CA; PIK3CG; PIK3CB
Function protein binding
Related Protein MTERFD2; CIAO1; ARHGEF12; FEZ1; SPC24; S100A16; GLRB; ESRP1; KIF13B; E2F4

Interacting Protein

PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.
PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY