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PIR

  • Official Full Name

    pirin (iron-binding nuclear protein)

  • Overview

    This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
  • Synonyms

    PIR; pirin (iron-binding nuclear protein); pirin; Iron binding nuclear protein; OTTHUMP00000022961; OTTHUMP00000022962; probable quercetinase; probable quercetin 2,3-dioxygenase PIR;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIR-5547H Recombinant Human Pirin (iron-binding nuclear protein), His-tagged His
Human PIR-1730H Recombinant Human PIR, GST-tagged E.coli GST 46-230aa
Human PIR-3169HCL Recombinant Human PIR 293 Cell Lysate HEK293 N/A
Human PIR-3168HCL Recombinant Human PIR 293 Cell Lysate HEK293 N/A
Human PIR-453H Recombinant Human PIR Protein, His-tagged E.coli His Met1~Asn290
Human PIR-6297H Recombinant Human PIR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse PIR-12833M Recombinant Mouse PIR Protein Mammalian Cell His
Mouse PIR-6759M Recombinant Mouse PIR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pir-4877M Recombinant Mouse Pir Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PIR-6759M-B Recombinant Mouse PIR Protein Pre-coupled Magnetic Beads HEK293
Rat PIR-4472R Recombinant Rat PIR Protein Mammalian Cell His
Rat PIR-4132R-B Recombinant Rat PIR Protein Pre-coupled Magnetic Beads HEK293
Rat PIR-4132R Recombinant Rat PIR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PIR-3439R Recombinant Rhesus monkey PIR Protein, His-tagged Mammalian Cell His
Rhesus Macaque PIR-3257R-B Recombinant Rhesus Macaque PIR Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PIR-3257R Recombinant Rhesus Macaque PIR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PIR-671Z Recombinant Zebrafish PIR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIR Related Articles

PIR involved in several pathways and played different roles in them. We selected most pathways PIR participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PIR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PIR has several biochemical functions, for example, metal ion binding, protein binding, quercetin 2,3-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIR itself. We selected most functions PIR had, and list some proteins which have the same functions with PIR. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZNF713;POLR2A;ACLY;PPP5C;SHHA;MMP14A;ZNF410;ZFPM2;MICALL2A
protein bindingCYTH3;TSPAN4;LSM11;LTBP1;TMEM110;MPZL1L;STAP2;NAA50;KIR2DL3
quercetin 2,3-dioxygenase activity
transcription cofactor activityMXD1;MED1;LDB1B;LDB1A;ZNF763;LDB2A;PSMC5;SLC26A3;MSX2

PIR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIR here. Most of them are supplied by our site. Hope this information will be useful for your research of PIR.

BCL3; SMAD9

Zhong, HH; Fazenbaker, C; et al. MEDI-573, Alone or in Combination with Mammalian Target of Rapamycin Inhibitors, Targets the Insulin-like Growth Factor Pathway in Sarcomas. MOLECULAR CANCER THERAPEUTICS 13:2662-2673(2014).
Moon, HY; Van, TL; et al. Cell-Surface Expression of Aspergillus saitoi-Derived Functional alpha-1,2-Mannosidase on Yarrowia lipolytica for Glycan Remodeling. JOURNAL OF MICROBIOLOGY 51:506-514(2013).
  • Q&As
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