pir
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  • Official Full Name
  • pirin (iron-binding nuclear protein)
  • Background
  • This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
  • Synonyms
  • PIR; pirin (iron-binding nuclear protein); pirin; Iron binding nuclear protein; OTTHUMP00000022961; OTTHUMP00000022962; probable quercetinase; probable quercetin 2,3-dioxygenase PIR
Cat.#:PIR-453HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIR Protein, His-tagged
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Cat.#:PIR-5547HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pirin (iron-binding nuclear protein), His-tagged
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Cat.#:PIR-1730HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIR, GST-tagged
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Cat.#:PIR-12833MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIR Protein
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Cat.#:PIR-4472RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIR Protein
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Cat.#:PIR-3439RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIR Protein, His-tagged
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Cat.#:PIR-671ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIR
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Cat.#:PIR-3168HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIR 293 Cell Lysate
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Cat.#:PIR-3169HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIR 293 Cell Lysate
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Protein Function

PIR has several biochemical functions, for example, metal ion binding, protein binding, quercetin 2,3-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIR itself. We selected most functions PIR had, and list some proteins which have the same functions with PIR. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein CDH24; TRIM12A; TIMP4; RARAA; TRIM35-23; FTR54; ZFP423; GART; B3GAT1; RRM2B
Function protein binding
Related Protein SUV420H2; DCTN4; APPL1; PIK3R2; MARCH10; S100A12; FGD5; NEFM; CDC23; MAK
Function quercetin 2,3-dioxygenase activity
Related Protein PIR
Function transcription cofactor activity
Related Protein MAX; HES6; IRF3; CALCOCO1; ELK4; NSD1; ZNF763; TFDP2; ZFP865; LDB1B

Interacting Protein

PIR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIR here. Most of them are supplied by our site. Hope this information will be useful for your research of PIR.
BCL3; SMAD9

PIR Related Articles

Zhong, HH; Fazenbaker, C; et al. MEDI-573, Alone or in Combination with Mammalian Target of Rapamycin Inhibitors, Targets the Insulin-like Growth Factor Pathway in Sarcomas. MOLECULAR CANCER THERAPEUTICS 13:2662-2673(2014).
Moon, HY; Van, TL; et al. Cell-Surface Expression of Aspergillus saitoi-Derived Functional alpha-1,2-Mannosidase on Yarrowia lipolytica for Glycan Remodeling. JOURNAL OF MICROBIOLOGY 51:506-514(2013).