pkd2
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  • Official Full Name
  • polycystic kidney disease 2 (autosomal dominant)
  • Background
  • As members of the calcium-/calmodulin-depedent protein kinase superfamily, there are three known Protein Kinase D receptor in stably-transfected AGS-B cells. Furthermore, PKD2 is found to be active during the early phase of differentation of C2C12 cells into skeletal muscle cells. It is also reported to enhance TCR-induced NFAT activity in Jurkat T cells.
  • Synonyms
  • PKD2; polycystic kidney disease 2 (autosomal dominant); polycystin-2; Pc 2; PC2; PKD4; transient receptor potential cation channel; subfamily P; member 2; TRPP2; R48321; polycystwin; autosomal dominant polycystic kidney disease type II protein; transient receptor potential cation channel, subfamily P, member 2; Pc-2; APKD2; MGC138466; MGC138468
Cat.#:PKD2-30689THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PKD2
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Cat.#:PKD2-410HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PKD2, GST-tagged, Active
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Cat.#:PKD2-12860MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PKD2 Protein
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Cat.#:PKD2-2812CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PKD2
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Cat.#:PKD2-459ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PKD2
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Cat.#:PKD2-660HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Polycystic Kidney Disease 2 (Autosomal Dominant)
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Involved Pathway

PKD2 involved in several pathways and played different roles in them. We selected most pathways PKD2 participated on our site, such as Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
CEP152; IFT43; TRAF3IP1; TMEM67; EXOC5; DYNLL2; EXOC6; MAPRE1B; CCT4; IFT74
Cargo trafficking to the periciliary membrane
ARL13B; PKD1; RHOL; EXOC5; UNC119B; BBS12; ARF4; EXOC6; PROL1; BBS2
Organelle biogenesis and maintenance
DYNLRB2; IFT43; FBF1; CYS1; CCDC41; IFT-20; MRPS22; TTC30A2; DYNLL2A; IFT88
VxPx cargo-targeting to cilium
ARF4; ARF4A; PKD2; RAB3IP; CNGA5; CNGA2; PKD1

Protein Function

PKD2 has several biochemical functions, for example, ATPase binding, HLH domain binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD2 itself. We selected most functions PKD2 had, and list some proteins which have the same functions with PKD2. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein RALB; CHRNA7; WFS1; SNTA1; ATP6V1E1; RAB4A; S100A1; ABCA1; CHMP4A; NSFL1C
Function HLH domain binding
Related Protein PKD2; UBE2I; SIRT1
Function actinin binding
Related Protein TTN; CSRP3; PROM1; PDLIM5; MICALL2; RELA; NFKB1; PKD2
Function calcium ion binding
Related Protein BGLAP-RS1; PCDHA4; PCDH1G32; CABP1A; AGRN; SLC25A13; MMP16; THBS4B; CALRL2; PLCB1
Function calcium-induced calcium release activity
Related Protein RYR2; PKD2; RYR3
Function cytoskeletal protein binding
Related Protein PTPN4A; FARP2; CDK5; CAPN1; ABI1; EPB41B; EPB41L4B; ALDOC; TOR1AIP1; FABP3
Function identical protein binding
Related Protein TTC32; ATF3; MAPK1IP1; ITGB3; MRAP2; PSMA7; ST13; NLRC4; DYNLT1B; ACADM
Function ion channel binding
Related Protein PACS1; KCNC1; HSP90AB1; SRI; CIB1; FXYD1; ANK2; BAK1; SLC8A1; NOS1
Function muscle alpha-actinin binding
Related Protein NRAP; LDB3; PKD2; MYPN; PKD2L1; TTN; PALLD; PDLIM2
Function phosphoprotein binding
Related Protein YWHAB; MS4A2; TBK1; IGF2R; CBX4; ARR3; SAG; YWHAE; SNCA; SFN
Function potassium channel activity
Related Protein KCNIP4; KCNF1; TMEM38B; KCNK1A; KCNK5B; KCNA1; KCNK16; KCNIP1; KCNF1A; KCNK10B
Function protein binding
Related Protein MPZL1L; IL18; GMIP; PSMD9; SLC11A2; NAPB; ZNF624; MED8; PDK1; ELK1
Function protein homodimerization activity
Related Protein NUDT21; STC2; NR6A1A; RAB11FIP3; UGT1A6; DMRT3; ENPP1; SYNE1; HMGCS1; FAM109A
Function receptor binding
Related Protein LGI1; FGF1A; GAS6; HLA-E; CADM1B; HMGCL; BAAT; NRXN1; STRAP; KCNJ10
Function voltage-gated calcium channel activity
Related Protein NCS1; CACNG7; CACNG2A; RYR1; CATSPER1; CACNA2D2; ATP6V0CB; OPRM1; CACNB3A; NALCN
Function voltage-gated cation channel activity
Related Protein GRIN2A; PKD2; HVCN1; GRIN1; GRIK1
Function voltage-gated ion channel activity
Related Protein KCNJ2A; KCNIP3; CACNA1SA; KCNV2B; KCNS3B; PKD2; KCNJ1A.6; SCN12AB; NALCN; CATSPER2
Function voltage-gated sodium channel activity
Related Protein SCN2A; SCN1LAB; SCN1A; SCN3A; SCN12AB; SCN8AB; SCN4AA; SCN11A; SCN8AA; SCN5A

Interacting Protein

PKD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD2.
PKD1; TRPC1

PKD2 Related Articles

Armacki, M; Joodi, G; et al. A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. ONCOGENE 33:1167-1180(2014).
Streets, AJ; Wessely, O; et al. Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation. HUMAN MOLECULAR GENETICS 22:1924-1939(2013).