PLN
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Official Full Name
phospholamban
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Overview
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. -
Synonyms
PLN; phospholamban; PLB; cardiac phospholamban; CMD1P; CMH18; PPLA_HUMAN; OTTHUMP00000017092;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PLN Related Articles
PLN involved in several pathways and played different roles in them. We selected most pathways PLN participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Calcium signaling pathway | AVPR1B;TRHR2;SLC25A4;ATP2B4;CYSLTR1;GNAS;P2RX8;CACNA1SB;ADRB2B |
cGMP-PKG signaling pathway | BAD;BNP;MEF2A;RGS2;KCNJ8;ATP1B4;CALM2;MAPK1;MEF2C |
cAMP signaling pathway | PPP1R12A;CNGA2;HTR1B;PIK3CG;GIPR;ARAP3;GRIN3A;CNGA1;CAMK2D |
Adrenergic signaling in cardiomyocytes | MAPK14A;CREB3L4;CACNB4;ATF4B1;TPMA;TPM1;AGTR1A;ADRB1;CACNG8 |
Thyroid hormone signaling pathway | PIK3R3;SLCO1C1;ATP1A3;KAT2B;RXRG;RXRB;FXYD2;ATP1A1;DIO3 |
Dilated cardiomyopathy | ITGA3;PRKACB;MYH7;ITGB4;ADRB1;TGFB3;TNF;ITGA9;MYL2 |
PLN has several biochemical functions, for example, ATPase binding, ATPase inhibitor activity, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLN itself. We selected most functions PLN had, and list some proteins which have the same functions with PLN. You can find most of the proteins on our site.
Function | Related Protein |
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ATPase binding | ATPIF1B;ANK2;DNAJB1;DERL1;ATP6V0A2;WFS1;ANK1;Ar;ATP1B2 |
ATPase inhibitor activity | ATPIF1A;ATPIF1;PLN;ATPIF1B |
calcium channel regulator activity | SGK3;GRM2;SGK2A;PRKCB;CACNA2D3;HPCAL4;NRXN2;NPY;CAV3 |
enzyme inhibitor activity | WFIKKN1;PRPSAP1;TXNIP;DGKZ;UGT1A7;SCG5;OAZ1A;WDTC1;APOV1 |
identical protein binding | AHCY;ADIPOQ;ROBO1;RYR2;SMAD3;ALCAMA;HSD17B10;HNRNPC;AKT1 |
protein binding | GSTO2;WHRN;FAM40A;MIB1;HHLA2;RAVER2;AKT1;GFPT2;FZD2 |
PLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLN here. Most of them are supplied by our site. Hope this information will be useful for your research of PLN.
DMPK; EDA; DVL3
- Q&As
- Reviews
Q&As (5)
Ask a questionPLN regulates cardiac contractility by fine-tuning calcium cycling, influencing the force of myocardial contractions.
Dysregulation of PLN in heart failure results in impaired calcium handling, contributing to contractile dysfunction and the progression of heart failure.
PLN has a transmembrane domain and interacts with SERCA through its cytoplasmic domain, forming a complex that modulates calcium transport.
Phosphorylation of PLN at specific sites, particularly by protein kinase A (PKA), relieves its inhibitory effect on SERCA, enhancing calcium reuptake into the sarcoplasmic reticulum.
PLN regulates muscle contraction by inhibiting the activity of the sarcoplasmic reticulum calcium pump (SERCA), modulating intracellular calcium levels.
Customer Reviews (3)
Write a reviewCustomer service provided valuable insights into the applications of this product, helping us make an informed decision.
The team promptly addressed my inquiries and provided valuable assistance in selecting the right recombined protein for our research.
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