pln
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  • Official Full Name
  • phospholamban
  • Background
  • The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
  • Synonyms
  • PLN; phospholamban; PLB; cardiac phospholamban; CMD1P; CMH18; PPLA_HUMAN; OTTHUMP00000017092
Cat.#:PLN-1489HTag:GST
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PLN Protein (1-52 aa), GST-tagged
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Cat.#:PLN-1791HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLN, GST-tagged
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Cat.#:PLN-1928HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLN protein, His & GST-tagged
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Cat.#:PLN-30732THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLN
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Cat.#:PLN-12983MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLN Protein
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Cat.#:PLN-4529RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PLN Protein
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Cat.#:PLN-3474RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PLN Protein, His-tagged
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Cat.#:PLN-6961CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLN
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Cat.#:PLN-7947ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PLN
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Involved Pathway

PLN involved in several pathways and played different roles in them. We selected most pathways PLN participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
PPP3R1B; TACR1A; EDNRB; ATP2B1A; PPIF; NTSR1; PLCD3A; ERBB4A; CALM1A; PRKCB
cGMP-PKG signaling pathway
PPP1R12A; ATP2B1; GNAQ; KCNJ8; NFATC1; GUCY1A3; SLC25A6; PPIF; NPPB; MAP2K2
cAMP signaling pathway
VIPR2; ATP2A2; VAV1; PIK3R2; GABBR1; FOS; NFKB1; CAMK2D; PDE3A; F2R
Adrenergic signaling in cardiomyocytes
CREB3L4; SLC8A1; PRKCA; PPP2R2BB; CALML5; ATP1B3B; CREB3L3L; ATP1A2A; PPP2R2A; MAPK12
Thyroid hormone signaling pathway
PIK3CA; PLN; TRP53; RHEB; MED30; PIK3CD; PRKCA; GATA4; CASP9; MED4
Dilated cardiomyopathy
LAMA2; TPM3; CACNA2D1; ITGA8; CACNA2D4; CACNG8; MYBPC3; PRKACG; ADRB1; ITGA9

Protein Function

PLN has several biochemical functions, for example, ATPase binding, ATPase inhibitor activity, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLN itself. We selected most functions PLN had, and list some proteins which have the same functions with PLN. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein TOR1AIP2; CAV1; ATP6V0A1A; PLN; SELS; ATP1B1; ATP6V0A1; ATP1B3; PDE4D; ATXN3
Function ATPase inhibitor activity
Related Protein ATPIF1A; ATPIF1B; ATPIF1; PLN
Function calcium channel regulator activity
Related Protein SGK1; TSPAN13A; CACNA2D4; SGK3; CACNA2D3; NPY; SRI; GNB2; CACNA2D2; SGK2
Function enzyme inhibitor activity
Related Protein PRPSAP1; UGT1A9; TAE1; WDTC1; WFIKKN1; UGT1A7; ATPIF1A; ANGPTL3; UGT1A1; CD46
Function identical protein binding
Related Protein IL12B; HNRNPC; NUFIP1; CLDN14; CLPP; CLDN7; TPRGL; CD74; NDC80; LYZ
Function protein binding
Related Protein SETD7; MAPK10; EIF4G1; TSPAN1; KSR1; SNAP91; LYN; FKBP7; MTA3; GPN1

Interacting Protein

PLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLN here. Most of them are supplied by our site. Hope this information will be useful for your research of PLN.
DMPK; EDA; DVL3

PLN Related Articles

El-Ghonaimy, EA; El-Shinawi, M; et al. Positive lymph-node breast cancer patients - activation of NF-kappa B in tumor-associated leukocytes stimulates cytokine secretion that promotes metastasis via C-C chemokine receptor CCR7. FEBS Journal 282:271-282(2015).
Ding, L; Gysemans, CA; et al. Combining MK626, a Novel DPP-4 Inhibitor, and Low-Dose Monoclonal CD3 Antibody for Stable Remission of New-Onset Diabetes in Mice. PLOS ONE 9:-(2014).