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PLN

  • Official Full Name

    phospholamban

  • Overview

    The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
  • Synonyms

    PLN; phospholamban; PLB; cardiac phospholamban; CMD1P; CMH18; PPLA_HUMAN; OTTHUMP00000017092;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLN-30732TH Recombinant Human PLN Wheat Germ N/A 30 amino acids
Human PLN-1928H Recombinant Human PLN protein, His & GST-tagged E.coli His/GST Met1~Leu52 (Accession # P26678)
Human PLN-1791H Recombinant Human PLN, GST-tagged E.coli GST 1-52aa
Human PLN-1489H Recombinant Human PLN Protein (1-52 aa), GST-tagged Yeast GST 1-52 aa
Human PLN-4936H Recombinant Human PLN Protein (Met1-Leu52), N-GST tagged E.coli N-GST Met1-Leu52
Mouse PLN-12983M Recombinant Mouse PLN Protein Mammalian Cell His
Mouse PLN-6856M Recombinant Mouse PLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PLN-6856M-B Recombinant Mouse PLN Protein Pre-coupled Magnetic Beads HEK293
Rat PLN-4529R Recombinant Rat PLN Protein Mammalian Cell His
Rat PLN-4189R-B Recombinant Rat PLN Protein Pre-coupled Magnetic Beads HEK293
Rat PLN-4189R Recombinant Rat PLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PLN-3474R Recombinant Rhesus monkey PLN Protein, His-tagged Mammalian Cell His
Rhesus Macaque PLN-3292R Recombinant Rhesus Macaque PLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PLN-3292R-B Recombinant Rhesus Macaque PLN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PLN-7947Z Recombinant Zebrafish PLN Mammalian Cell His
Chicken PLN-6961C Recombinant Chicken PLN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PLN Related Articles

PLN involved in several pathways and played different roles in them. We selected most pathways PLN participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayAVPR1B;TRHR2;SLC25A4;ATP2B4;CYSLTR1;GNAS;P2RX8;CACNA1SB;ADRB2B
cGMP-PKG signaling pathwayBAD;BNP;MEF2A;RGS2;KCNJ8;ATP1B4;CALM2;MAPK1;MEF2C
cAMP signaling pathwayPPP1R12A;CNGA2;HTR1B;PIK3CG;GIPR;ARAP3;GRIN3A;CNGA1;CAMK2D
Adrenergic signaling in cardiomyocytesMAPK14A;CREB3L4;CACNB4;ATF4B1;TPMA;TPM1;AGTR1A;ADRB1;CACNG8
Thyroid hormone signaling pathwayPIK3R3;SLCO1C1;ATP1A3;KAT2B;RXRG;RXRB;FXYD2;ATP1A1;DIO3
Dilated cardiomyopathyITGA3;PRKACB;MYH7;ITGB4;ADRB1;TGFB3;TNF;ITGA9;MYL2

PLN has several biochemical functions, for example, ATPase binding, ATPase inhibitor activity, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLN itself. We selected most functions PLN had, and list some proteins which have the same functions with PLN. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingATPIF1B;ANK2;DNAJB1;DERL1;ATP6V0A2;WFS1;ANK1;Ar;ATP1B2
ATPase inhibitor activityATPIF1A;ATPIF1;PLN;ATPIF1B
calcium channel regulator activitySGK3;GRM2;SGK2A;PRKCB;CACNA2D3;HPCAL4;NRXN2;NPY;CAV3
enzyme inhibitor activityWFIKKN1;PRPSAP1;TXNIP;DGKZ;UGT1A7;SCG5;OAZ1A;WDTC1;APOV1
identical protein bindingAHCY;ADIPOQ;ROBO1;RYR2;SMAD3;ALCAMA;HSD17B10;HNRNPC;AKT1
protein bindingGSTO2;WHRN;FAM40A;MIB1;HHLA2;RAVER2;AKT1;GFPT2;FZD2

PLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLN here. Most of them are supplied by our site. Hope this information will be useful for your research of PLN.

DMPK; EDA; DVL3

El-Ghonaimy, EA; El-Shinawi, M; et al. Positive lymph-node breast cancer patients - activation of NF-kappa B in tumor-associated leukocytes stimulates cytokine secretion that promotes metastasis via C-C chemokine receptor CCR7. FEBS Journal 282:271-282(2015).
Ding, L; Gysemans, CA; et al. Combining MK626, a Novel DPP-4 Inhibitor, and Low-Dose Monoclonal CD3 Antibody for Stable Remission of New-Onset Diabetes in Mice. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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What is the role of PLN in the regulation of cardiac contractility? 05/11/2022

PLN regulates cardiac contractility by fine-tuning calcium cycling, influencing the force of myocardial contractions.

How does PLN contribute to the pathophysiology of heart failure? 07/03/2021

Dysregulation of PLN in heart failure results in impaired calcium handling, contributing to contractile dysfunction and the progression of heart failure.

Can you explain the structural features of PLN and its interaction with SERCA? 11/08/2020

PLN has a transmembrane domain and interacts with SERCA through its cytoplasmic domain, forming a complex that modulates calcium transport.

How does phosphorylation regulate the activity of PLN? 04/16/2019

Phosphorylation of PLN at specific sites, particularly by protein kinase A (PKA), relieves its inhibitory effect on SERCA, enhancing calcium reuptake into the sarcoplasmic reticulum.

What is the molecular function of PLN in the context of muscle contraction? 08/27/2018

PLN regulates muscle contraction by inhibiting the activity of the sarcoplasmic reticulum calcium pump (SERCA), modulating intracellular calcium levels.

Customer Reviews (3)

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Reviews
03/16/2022

    Customer service provided valuable insights into the applications of this product, helping us make an informed decision.

    03/02/2019

      The team promptly addressed my inquiries and provided valuable assistance in selecting the right recombined protein for our research.

      06/23/2018

        Lightning-fast delivery!

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