|Official Full Name||patatin-like phospholipase domain containing 6|
|Background||This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||PNPLA6; patatin-like phospholipase domain containing 6; neuropathy target esterase; NTE; sws; EC 220.127.116.11; NTEMND; Patatin like phospholipase domain containing 6; Patatin like phospholipase domain containing protein 6; Patatin-like phospholipase domain-containing protein 6; PLPL6_HUMAN; SPG39|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PNPLA6 involved in several pathways and played different roles in them. We selected most pathways PNPLA6 participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Glycerophospholipid metabolism||LCAT; GNPAT; PPAP2C; CHAT; GPAM; PLD4; PLA2G4F; PNPLA6; PCYT1BA; DGKZ|
PNPLA6 has several biochemical functions, for example, lysophospholipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA6 itself. We selected most functions PNPLA6 had, and list some proteins which have the same functions with PNPLA6. You can find most of the proteins on our site.
|lysophospholipase activity||ENPP2; PNPLA7; MGLL; PLA2G4AA; PNPLA8; LGALS13; PLA2G15; PLB1; Cel; LYPLA1|
PNPLA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA6.