PNPLA6 Protein, patatin-like phospholipase domain containing 6


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Official Full Name patatin-like phospholipase domain containing 6
Background This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms PNPLA6; patatin-like phospholipase domain containing 6; neuropathy target esterase; NTE; sws; EC; NTEMND; Patatin like phospholipase domain containing 6; Patatin like phospholipase domain containing protein 6; Patatin-like phospholipase domain-containing protein 6; PLPL6_HUMAN; SPG39
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PNPLA6-1819H Recombinant Human PNPLA6, His-tagged E.coli His
    Human PNPLA6-2408H Recombinant Human PNPLA6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PNPLA6-29926TH Recombinant Human PNPLA6, His-tagged E.coli His
    Mouse PNPLA6-13045M Recombinant Mouse PNPLA6 Protein Mammalian Cell His
    Chicken PNPLA6-3804C Recombinant Chicken PNPLA6 Mammalian Cell His

    PNPLA6 involved in several pathways and played different roles in them. We selected most pathways PNPLA6 participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism LCAT; GNPAT; PPAP2C; CHAT; GPAM; PLD4; PLA2G4F; PNPLA6; PCYT1BA; DGKZ

    PNPLA6 has several biochemical functions, for example, lysophospholipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA6 itself. We selected most functions PNPLA6 had, and list some proteins which have the same functions with PNPLA6. You can find most of the proteins on our site.

    Function Related Protein
    lysophospholipase activity ENPP2; PNPLA7; MGLL; PLA2G4AA; PNPLA8; LGALS13; PLA2G15; PLB1; Cel; LYPLA1

    PNPLA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA6.


    Wei, N; Wang, Y; et al. PU.1 antisense lncRNA against its mRNA translation promotes adipogenesis in porcine preadipocytes. ANIMAL GENETICS 46:133-140(2015).
    Zhou, Y; Llaurado, G; et al. Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. JOURNAL OF HEPATOLOGY 62:657-663(2015).

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