ppp1r15a
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  • Official Full Name
  • protein phosphatase 1, regulatory subunit 15A
  • Background
  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.
  • Synonyms
  • PPP1R15A; protein phosphatase 1, regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; protein phosphatase 1 regulatory subunit 15A; GADD34; growth arrest and DNA damage inducible 34; growth arrest and DNA-damage-inducible 34
Cat.#:Ppp1r15a-397MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ppp1r15a Protein, His-tagged
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Cat.#:Ppp1r15a-398RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ppp1r15a Protein, His-tagged
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Cat.#:PPP1R15A-15HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PPP1R15A Protein, GST-tagged
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Cat.#:PPP1R15A-2943HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPP1R15A protein, MYC/DDK-tagged
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Cat.#:PPP1R15A-4619RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP1R15A Protein
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Cat.#:PPP1R15A-5291ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP1R15A
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Cat.#:PPP1R15A-2943HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP1R15A 293 Cell Lysate
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Involved Pathway

PPP1R15A involved in several pathways and played different roles in them. We selected most pathways PPP1R15A participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R15A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
TRAF2; DAD1; DNAJB12; DNAJB2; UBE2D1A; STT3A; SYVN1; SEC61G; DNAJB1A; HSPA4L

Protein Function

PPP1R15A has several biochemical functions, for example, protein binding, protein kinase binding, protein phosphatase 1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R15A itself. We selected most functions PPP1R15A had, and list some proteins which have the same functions with PPP1R15A. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein OLA1; SUPV3L1; RTN4R; FBXO45; F3; UBE2O; ELF4; ZMAT4; PEX2; CD40
Function protein kinase binding
Related Protein AGTR1A; GYS1; AP1B1; MAP2K6; FER; FAF1; AKAP7; PPP1R12A; RFFL; SFN
Function protein phosphatase 1 binding
Related Protein PAWR; PHACTR4B; PHACTR3B; PHACTR3; Fert2; STAU1; PPP1R9B; PHACTR1; TCTEX1D4; PPP1R11
Function protein phosphatase type 1 activator activity
Related Protein PHACTR4B; PPP1R15A; PHACTR4
Function protein phosphatase type 1 regulator activity
Related Protein PPP1R16A; PHACTR3; KCNS1; PHACTR3B; PPP1R7; PPP1R15A; PHACTR1; UBXN2A; PPP1R8; UBXN2B

Interacting Protein

PPP1R15A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R15A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R15A.
CTBP2; PPP1R1A; Dlg4; microcystin-lr; MYC; POU3F3; BCAR1; PPP1CA; trpE; q81l21_bacan; secA2; q81w74_bacan; ZNF512B

PPP1R15A Related Articles

Ohri, SS; Mullins, A; et al. Inhibition of GADD34, the Stress-Inducible Regulatory Subunit of the Endoplasmic Reticulum Stress Response, Does Not Enhance Functional Recovery after Spinal Cord Injury. PLOS ONE 9:-(2014).
Yong, KJ; Milenic, DE; et al. Impact of alpha-Targeted Radiation Therapy on Gene Expression in a Pre-Clinical Model for Disseminated Peritoneal Disease when Combined with Paclitaxel. PLOS ONE 9:-(2014).