prkaca
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, alpha
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the;cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The;inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the;dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric;catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.;The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of;cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been;observed.
  • Synonyms
  • PRKACA; protein kinase, cAMP-dependent, catalytic, alpha; cAMP-dependent protein kinase catalytic subunit alpha; PKACa; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; MGC48865; MGC102831
Cat.#:PRKACA-2952HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRKACA Protein, MYC/DDK-tagged
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Cat.#:PRKACA-31113THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACA
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Cat.#:PRKACA-394HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACA, GST-tagged, Active
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Cat.#:PRKACA-547HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRKACA
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Cat.#:PRKACA-552HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACA, GST-tagged
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Cat.#:PRKACA-55643HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACA, GST-tagged
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Cat.#:PRKACA-13352MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACA Protein
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Cat.#:Prkaca-608MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prkaca
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Cat.#:PRKACA-1415HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PRKACA cell lysate
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Involved Pathway

PRKACA involved in several pathways and played different roles in them. We selected most pathways PRKACA participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
ACVR1C; PDGFRB; FOS; KRAS; C11orf52; ZAK; MAPK4; PPP3CA; FGFR2; HSPA1L
Ras signaling pathway
KSR2; KRAS; ABL2; PRKCG; GRB2; INS2; INS1; PIK3R3; RAC2; NRAS
Calcium signaling pathway
TBXA2R; PLCD3; CAMK2D1; NOS2; SLC8A1A; HTR2CL1; P2RX1; BDKRB2; EDNRB2; CCKBR
cAMP signaling pathway
RRAS2; HTR1E; MAPK1; PPP1R12A; F2R; GRIA4; PDE4A; PDE3A; NFKBIA; RELA
Chemokine signaling pathway
CCL3L1; FGR; CCR5; Ccl21a; VAV2; IKBKB; CXCR5; CXCL9; WAS; CCL17
Oocyte meiosis
YWHABA; CCNB2; SMC1A; YWHAH; PRKACB; RPS6KA6; PRKACAA; PTTG1; ANAPC4; PPP2CB
Apoptosis
PPP3R1; DFFB; CASP6L1; TNFRSF10B; PANK1A; MYD88; CRADD; PRKAR1B; DSG3; TP53
Adrenergic signaling in cardiomyocytes
PPP1CB; PPP1CC; ATP1B1A; ATP2B3B; CREB1A; SLC8A1; CAMK2D2; GNAQ; NETO2; TPM4
Vascular smooth muscle contraction
GNA15.4; AVPR1B; ROCK2; PLA2G4C; GNA11; PRKG1A; CALM3B; CALM1; PLA2G4AA; CALM1A
Wnt signaling pathway
DVL1B; CUL1; PRKCBA; FZD6; PSEN1; RHOAA; FOSL1; WNT6; SMAD4; RAC1
Hedgehog signaling pathway
Shh; WNT3; IHHA; SAP18; WNT2B; CSNK1G2B; ZIC2; SKIA; WNT9B; WNT5B
Gap junction
GRB2B; DRD1B; RAF1; GNAI1; TUBB2; GRM1; KRAS; TUBA3A; DRD2A; GUCY1B3
Platelet activation
FGB; P2RY1; GUCY1B3; GNAI1; GNAI3; PIK3CA; PIK3R3; P2RX1; MYL12B; PLCG2
Circadian entrainment
AKR1C1; RASD1; PER3; CAMK2B; CALML5; CACNA1G; GNB2; KCNJ3; GNG10; GNB4
Long-term potentiation
PLCB1; GRIN2D; CALM3; CAMK2B; PPP3CA; PPP1CA; PLCB2; CALML5; ITPR1; RPS6KA2
Retrograde endocannabinoid signaling
GABRE; DAGLB; GNAO1; GNG8; GABRB3; PLCB2; GABRB2; MAPK3; ABHD6; GABRR2
Glutamatergic synapse
GNG2; GNB1; SLC38A2; GNGT1; GRM8; PPP3R2; GRIN1; GNG4; PLD2; SLC1A6
Cholinergic synapse
GNG10; GNG13; PRKCA; GNAI2; CREB3L2; FOS; CHRM1; CHRM3; GNGT1; MAP2K1
Serotonergic synapse
HTR5A; GNB3; SLC18A2; GNAI1; PLCB2; HTR1E; SLC6A4; GNAS; ALOX12E; GNG11
GABAergic synapse
GABRA6; GNG7; GNAI1; PRKCA; SLC6A13; GNG5; GABRA3; GNB1; GNG12; PLCL1
Dopaminergic synapse
SLC6A3; PLCB4; PPP3CC; PPP3CB; AKT2; GRIN2A; CALM1; CAMK2D; GNB1; GNG11
Olfactory transduction
CLCA1; OLFR473; OR3A2; OLFR482; OLFR508; OR4N4; OLFR688; OLFR958; CAMK2G; OLFR494
Taste transduction
Adcy4; TAS2R123; TAS2R117; TAS2R129; TAS2R134; TAS2R130; TAS2R136; TAS2R139; PLCB2; TAS2R3
Inflammatory mediator regulation of TRP channels
P2RY2; IL1B; PIK3R2; TRPV1; ASIC3; NTRK1; CALML3; PIK3CG; PPP1CA; HTR2A
Insulin signaling pathway
FBP1; INSRA; CALM2; IKBKB; PRKAG3B; CALM3A; G6PC3; PKLR; RPS6KB1; GSK3AA
Insulin secretion
TRPM4; ITPR3; KCNN3; PLCB4; ADCYAP1; PRKACA; GNA11; PLCB3; KCNMB4; FXYD2
GnRH signaling pathway
MAP2K2; CACNA1D; PRKACG; PLA2G4D; CAMK2D1; CAMK2B; MAP2K1; MAP3K4; GNA11A; PLA2G4A
Ovarian steroidogenesis
BMP6; HSD17B2; PLA2G4F; CYP2J5; PLA2G4C; GDF9; IGF1R; GNAS; STAR; HSD3B4
Progesterone-mediated oocyte maturation
MAPK8A; AKT3A; BRAF; CPEB1; BUB1; MAPK13; CDC16; CPEB1A; PRKACAA; MAPK12B
Estrogen signaling pathway
PIK3R3; GNAQ; PRKCD; CALM1; CALML3; PIK3CG; RAF1; CALM2; HSPA8; GNAI3
Melanogenesis
DCT; Kitl; PRKCA; HRAS; CALM3A; GNAI2B; PRKCB; WNT5A; CREB1A; GNAQ
Thyroid hormone synthesis
ATP1A3; ATP1B4; GNAS; SLC5A5; ITPR1; ATP1B1; GSR; FXYD2; HSP90B1; PLCB2
Thyroid hormone signaling pathway
MAPK1; RAF1; ATP1B4; ATP1A4; ACTB; MED4; RCAN1; RXRG; SLC9A1; TRP53
Oxytocin signaling pathway
PRKCA; PLA2G4C; NFATC2; CACNG8; PRKACB; PIK3R2; PIK3R1; PRKAG2; PLA2G4D; EEF2K
Glucagon signaling pathway
CALM2; PYGB; PGAM1; PRKAG2; PHKB; PRKAB1; PHKA1; CPT1C; GYS2; PRKACG
Regulation of lipolysis in adipocytes
PRKG1; ABHD5; PTGER3; PIK3R5; TSHB; PTGS2; PIK3CG; GNAI1; PDE3B; TSHR
Renin secretion
LOC100328615; PPP3CC; GNAS; CALML5; PDE1A; CLCA3; CLCA2; PRKACA; GNAQ; ORAI1
Aldosterone synthesis and secretion
SLC14A2; ITPR3; ATF6B; CREB3L4; PRKCE; CAMK2A; PLCB3; ADCY1; AKR1C1; PLCB1
Endocrine and other factor-regulated calcium reabsorption
KLK1B24; CALB1; GNAQ; ATP1A3; PLCB4; ATP1A2; KLK1B26; ATP1B2; KLK1B22; PRKCA
Vasopressin-regulated water reabsorption
STX4; NSF; RAB11B; DYNC1LI1; DYNC1I1; AVP; VAMP2; PRKACG; PRKACA; DCTN4
Salivary secretion
DMBT1; ATP1B1; CALM4; ITPR1; ATP1A1; ATP1A4; Slc4a2; MUC5B; PRB1; CALML5
Gastric acid secretion
PLCB2; Slc4a2; PRKCA; PRKACG; KCNJ2; SSTR2; CAMK2D; ITPR3; ATP1B4; ATP1B3
Bile secretion
ATP1A1; ATP1B1; ATP1A4; SLCO1A5; SLCO1A2; OSTB; ATP1A2; Slc4a2; NCEH1; AQP1
Parkinsons disease
NDUFC2; UBE2G2; NDUFA3; UQCR10; NDUFB1; UBE2J1; NDUFS8; UCHL1; UQCRFS1; mt-Atp8
Prion diseases
MAP2K1; NCAM2; C8A; IL6; IL1A; C1QB; MAPK1; BAX; LAMC1; PRKACG
Cocaine addiction
GRIN2A; DRD1; GNAI3; GRIN2D; GRIN3A; NFKB1; CREB3L1; RGS9; GPSM1; GRIA2
Amphetamine addiction
ARC; CAMK2G; HDAC1; PPP1CB; ATF6B; PPP3R2; CREB3L3; SLC18A2; CALM2; GRIN2A
Morphine addiction
GNGT2; PDE4B; PDE7B; ARRB1; GNAO1; GNG3; GNG13; GNB2; PRKACB; GABRA6
Alcoholism
HIST1H4L; HIST1H2BA; HIST1H2AP; HIST1H3D; HDAC8; ATF6B; ATF4; HIST1H2AG; HIST1H2BP; PDYN
Vibrio cholerae infection
PRKCA; ATP6V1B1; ATP6V1A; MUC2; ATP6V1F; ATP6V1E1; ATP6V1E2; ATP6V0A1; ACTG1; ATP6V1G1
Amoebiasis
PIK3R1; COL27A1; ACTN3; LAMC3; PIK3CD; PRKCG; HSPB1; SERPINB1C; TGFB2; RAB7A
HTLV-I infection
TRP53INP1; MSX1; PDGFRB; WNT4; PIK3CB; KAT2B; PPP3CC; CD3G; PIK3R5; HLA-DRB3
Epstein-Barr virus infection
CR2; POLR2F; HLA-DQA1; HLA-DPB1; PIK3CG; POLR2J2; YWHAH; PIK3CD; HSPA1L; EIF2AK3
Pathways in cancer
FZD5; RALB; FZD6; PPARG; CCDC6; WNT1; PML; FAS; AGTR1A; RBX1
Viral carcinogenesis
PIK3R5; SRF; NFKB2; RHOA; HIST1H2BG; YWHAE; H2BFWT; CCNE2; POLB; Casp3
Proteoglycans in cancer
PRKACA; AKT1; ITGB3; WNT11; ROCK2; PPP1R12A; ERBB3; FZD1; MRAS; TWIST1
Dilated cardiomyopathy
MYL3; ITGA5; PRKACA; CACNG2; TPM4; CACNA2D4; TNF; ITGB8; SLC8A1; Itga10&Itgb1

Protein Function

PRKACA has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACA itself. We selected most functions PRKACA had, and list some proteins which have the same functions with PRKACA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein FPGS; XRCC5; RAF1B; ACVR1BA; PDK4; DYNC1H1; PDPK1B; MYO7B; ACTR1; ACTA1A
Function cAMP-dependent protein kinase activity
Related Protein AKAP13; PRKAA1; PRKACB; PRKAG1; PRKACA; PRKX; PRKACG
Function protein binding
Related Protein KLF10; CPSF2; SEC63; GDPD5; FAM200A; MAP3K9; TMEM8B; OS9; S100B; BBS2
Function protein complex binding
Related Protein CALY; RPAIN; DLG4; ATP6V1B1; ADRB2; PRKACA; LEPRE1; GIT1; CALCA; VDAC1
Function protein kinase A regulatory subunit binding
Related Protein AKAP8; PRKACA; RYR2; AKAP5; ARFGEF1; ARFGEF2; EZR; PJA2; KCNQ1; AKAP1
Function protein kinase binding
Related Protein KIF11; FGF19; TSACC; AKAP7; TOM1L1; EEF2; PPME1; POLA1; H2AFY; KCNQ3
Function protein serine/threonine/tyrosine kinase activity
Related Protein RPS6KA2; RPS6KB1; TNK2; MAP2K1; DYRK4; CLK1; DYRK3; AKT1; AURKB; MAP2K2
Function ubiquitin protein ligase binding
Related Protein PINK1; TNFRSF1B; TCEB2; FZD8; BCL2; HDAC6; MAGEC2; RNF40; CUL1; TRIOBP

Interacting Protein

PRKACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACA here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACA.
PRKAR1A; PRKAR2B; GSK3B; PRKAR2A; PRKAR1B; LRRK2