prkaca
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, alpha
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the;cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The;inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the;dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric;catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.;The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of;cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been;observed.
  • Synonyms
  • PRKACA; protein kinase, cAMP-dependent, catalytic, alpha; cAMP-dependent protein kinase catalytic subunit alpha; PKACa; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; MGC48865; MGC102831
Cat.#:PRKACA-2952HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRKACA Protein, MYC/DDK-tagged
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Cat.#:PRKACA-31113THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACA
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Cat.#:PRKACA-394HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACA, GST-tagged, Active
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Cat.#:PRKACA-547HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRKACA
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Cat.#:PRKACA-552HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACA, GST-tagged
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Cat.#:PRKACA-55643HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACA, GST-tagged
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Cat.#:PRKACA-13352MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACA Protein
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Cat.#:Prkaca-608MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prkaca
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Cat.#:PRKACA-1415HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACA cell lysate
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Involved Pathway

PRKACA involved in several pathways and played different roles in them. We selected most pathways PRKACA participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG6; RAC1A; MAPKAPK2A; MAPKAPK5; CACNB4; CD14; FAS; TAOK1; PAK2A; GRB2
Ras signaling pathway
BCL2L1; RAPGEF5; PLA2G12A; PIK3R1; RASSF1; GNB2; PLA2G4D; PRKCA; PIK3R3; FGF18
Calcium signaling pathway
TACR2; ATP2B1A; CALML3; ADCY1A; CAMK2D1; ATP2A1L; GNAS; GRIN1B; PRKACA; VDAC2
cAMP signaling pathway
ACOX1; ATP1A2; ATP2B1; RAC3; ATP1B2; RAP1B; GRIN2D; PIK3CG; NFKBIA; PIK3R2
Chemokine signaling pathway
SHC1; CCL26; CXCL2; CCL21; GRB2; CCL28; PRKCD; FOXO3; GNGT1; GSK3B
Oocyte meiosis
RBX1; CDC27; PTTG2; SGOL1; MAPK12B; CDC23; PPP2R1B; CALM1B; PPP1CAB; CALM
Apoptosis
PPP3CB; PRKACBB; IRF4A; BID; NFKB1; PRKACG; YWHAQ; DFFB; DBNLB; TNFRSF10D
Adrenergic signaling in cardiomyocytes
AGTR2; SCN5A; PIK3CB; PPP1R1A; PIK3R5; ATP1A1; CREB5; ADCY2B; Adcy4; PPP2R5C
Vascular smooth muscle contraction
GNA12A; ADCY1A; MAPK1; PRKCBB; PLA2G4F; ADORA2AB; GNA15.1; KCNMB2; GNA12; RAF1B
Wnt signaling pathway
CAMK2B; FBXW11; SFRP4; SIAH2L; FZD5; CCND3; PPP3CB; TBL1X; PPP3CC; SKP1
Hedgehog signaling pathway
CSNK1G1; GLI3; WNT11B; BMP2B; LRP2; ZIC2; ZIC2B; WNT11; PRKACAB; GAS1
Gap junction
TUBA3A; MAP2K5; TUBB2B; MAP2K1; HTR2CL1; GNAI2A; PDGFC; DRD1A; TUBA4A; TJP1
Platelet activation
PLCB2; ROCK2; PIK3R3; P2RY12; GNAI1; MAPK11; GP1BA; PRKACB; ARHGAP35; ITGA2
Circadian entrainment
CALM4; CALM1; GUCY1A3; CAMK2B; GNGT2; GNG8; GRIN2D; RASD1; CAMK2D; PER1
Long-term potentiation
RAP1B; PRKCG; PPP3R2; CALML5; PRKCB; CAMK2A; RAF1; CALM2; CAMK4; RPS6KA3
Retrograde endocannabinoid signaling
GABRG3; GNG13; GNG7; ITPR3; MAPK10; GNG8; GABRA2; GNG5; RIMS1; ABHD6
Glutamatergic synapse
PPP3CA; PRKACA; SLC38A1; PPP3R2; GRIN2A; ADRBK2; PPP3R1; PPP3CC; GNB4; GRIN2B
Cholinergic synapse
GNB1; GNA11; GNAI2; PLCB1; CHRNB2; CAMK4; GNG3; KCNQ4; AKT1; CAMK2A
Serotonergic synapse
GNB2; CYP2D10; GNG2; SLC18A1; GNG13; TPH2; GNG3; HTR3B; PLCB4; GABRB3
GABAergic synapse
GNB1; PRKACG; SRC; GABARAPL1; GNG11; PRKACB; GABBR1; SLC38A5; GNB3; GNG7
Dopaminergic synapse
PPP2R5B; KCNJ3; GRIA4; MAOB; GNB1; PRKCG; PLCB3; GNAI1; CREB3; KCNJ6
Olfactory transduction
CAMK2D; OLFR478; OR56A1; OLFR50; OR5K1; SLC8A1; CALM2; OLFR469; OR5H1; OR2K2
Taste transduction
TAS2R7; TAS2R109; TAS2R107; TAS2R116; Adcy4; TAS2R3; TRPM5; TAS2R121; TAS2R136; ALPHA-ENAC
Inflammatory mediator regulation of TRP channels
CALML5; IGF1; ASIC1; PIK3CB; PRKACG; PRKCA; PRKACA; MAPK8; TRPV3; CALM1
Insulin signaling pathway
CALM1; CALM1A; PRKAG3; PRKAR1B; IRS4; MKNK1; PPP1CC; SHC3; EIF4E1B; PDE3B
Insulin secretion
CAMK2G; CREB3L1; GCG; KCNMB4; SLC2A2; PLCB2; ADCYAP1; ATP1A4; PCLO; PLCB4
GnRH signaling pathway
MAP2K2A; PLA2G4A; KRAS; Adcy4; GNA11; ATF4; GRB2; MMP14; SRC; CALM
Ovarian steroidogenesis
PLA2G4F; GDF9; HSD3B2; INS; PLA2G4D; INS2; HSD17B2; PTGS2; HSD17B7; IGF1R
Progesterone-mediated oocyte maturation
CDC25B; RPS6KA2; PRKACA; GNAI2A; ANAPC11; HSP90AB1; PIK3CB; ANAPC4; CPEB2; PRKACG
Estrogen signaling pathway
HSP90AA1; ESR1; CALM4; HSP90AB1; KCNJ6; OPRM1; NOS3; CALML3; PIK3CB; PLCB4
Melanogenesis
GSK3B; CALM1B; FZD3A; WNT6; EDNRB2; TCF7L2; FZD7; WNT3; WNT5B; MITFB
Thyroid hormone synthesis
PRKCB; HSP90B1; PLCB3; SLC5A5; CREB3L1; PRKCG; PLCB4; GPX5; GNAQ; ITPR3
Thyroid hormone signaling pathway
THRA; GATA4; SRC; HRAS; HIF1A; NCOA1; PIK3R5; WNT4; SLC16A10; NOTCH3
Oxytocin signaling pathway
CACNB4; PRKAA2; MAPK7; MAP2K5; MEF2C; PRKACG; PLA2G4D; RYR2; NFATC2; NFATC3
Glucagon signaling pathway
PDE3B; PRKAB2; PHKA1; PPP3CC; PRMT1; LDHAL6B; GYS2; PDHA2; PPP3R1; PGAM2
Regulation of lipolysis in adipocytes
PIK3R2; PRKACB; PIK3CA; IRS1; PRKG1; GNAI3; NPR1; PIK3R5; PRKACA; LOC100328615
Renin secretion
GNAI1; GNAI2; GUCY1B3; CALM1; Ren1; PPP3CC; PLCB1; GUCY1A3; CALM4; PLCB2
Aldosterone synthesis and secretion
CACNA1G; CALM4; CAMK2A; PRKD3; ADCY7; PRKCE; MC2R; KCNK9; CYP21A1; LIPE
Endocrine and other factor-regulated calcium reabsorption
PRKACG; DNM3; PTH1R; ATP1A4; VDR; GNAS; ATP1B1; PLCB1; PLCB2; PLCB4
Vasopressin-regulated water reabsorption
PRKACA; DCTN4; ARHGDIA; DCTN6; CREB3L2; DYNLL1; PRKACG; DYNC1LI1; RAB5C; DYNC2H1
Salivary secretion
MUC7; BEST2; CD38; PRKCA; PMAP-36; KCNN4; PRB1; PRKG2; PRH2; CALM3
Gastric acid secretion
PLCB2; GNAI1; GNAQ; CA2; KCNQ1; KCNJ16; PRKACA; ATP1A3; ATP4A; ATP1B2
Bile secretion
NR0B2; SLC5A1; ADCY9; SLCO1B2; SLCO1B3; PRKACB; GNAS; Abcb1b; SLC22A8; Car2
Parkinsons disease
COX8C; ATP5C1; NDUFB1; UBE2L3; mt-Atp8; SLC25A5; NDUFA1; UBE2G1; PRKACA; GNAI2
Prion diseases
FYN; HSPA1A; C7; C8G; NCAM1; C6; C5; C1QC; NCAM2; C8A
Cocaine addiction
CREB3L1; NFKB1; CDK5R1; GNAI2; GRM2; CREB3L3; ATF6B; SLC18A2; ATF4; GRM3
Amphetamine addiction
MAOB; DRD1A; GRIN2C; CREB3L4; PRKACG; GRIN3B; CALM3; GRIN2A; PRKCG; CREB3L2
Morphine addiction
GNG2; GABRB2; GNGT1; GNAO1; GABRE; GABRG3; PDE4C; GNG13; GABRA1; PDE3B
Alcoholism
H2BFWT; RAF1; MAOB; HIST1H2AJ; PDYN; GNG8; GNGT2; HIST1H3F; H2AFZ; DDC
Vibrio cholerae infection
ATP6V1D; ACTG1; PLCG1; ATP6AP1; ATP6V0B; PRKACG; PRKACA; ATP6V1G2; ATP6V1C2; SEC61G
Amoebiasis
IFNG; TLR2; ITGB2; CD1d1; PIK3CA; PLCB3; SERPINB3; COL24A1; COL4A5; TGFB1
HTLV-I infection
MAP3K3; SLC2A1; RRAS; POLE3; GPS2; KAT2B; NFKB1; HLA-DRB1; CCND2; ETS2
Epstein-Barr virus infection
HSPA1L; NFKBIE; PRKACG; POLR3F; FGR; HSPA6; CD38; SYK; VIM; HSPA2
Pathways in cancer
PIK3CG; FGF11; STAT1; CSF3R; F2R; GNG2; LAMA3; Fasl; PTGER4; FH1
Viral carcinogenesis
GTF2H3; HIST1H2BI; HIST1H2BF; SCRIB; HLA-B; HIST1H4M; PRKACG; RBL1; HLA-E; HIST1H2BC
Proteoglycans in cancer
HSPB2; ACTB; TLR2; HOXD10; MAP2K2; PRKCB; FZD5; BRAF; CD44; CBL
Dilated cardiomyopathy
TGFB1; PRKACG; CACNG3; ITGB8; ITGA9; TNNC1; TTN; DES; PRKACB; DMD

Protein Function

PRKACA has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACA itself. We selected most functions PRKACA had, and list some proteins which have the same functions with PRKACA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP10A; MAPK4; BCS1L; MYH1; MYO7AA; KIF1B; PRKCHB; FES; RIPK1L; ABCB8
Function cAMP-dependent protein kinase activity
Related Protein AKAP13; PRKX; PRKAG1; PRKAA1; PRKACG; PRKACA; PRKACB
Function protein binding
Related Protein SDCBP; LRRC47; POLB; RTN2; PADI4; EPAS1; EGFR; RLTPR; ARHGEF38; CITED2
Function protein complex binding
Related Protein STRN; CYFIP1; LRP2; SKIL; SLC9A3R1; CASP8; TWF1; Ctsl; UGT1A6A; HCLS1
Function protein kinase A regulatory subunit binding
Related Protein KCNQ1; AKAP8; PJA2; ARFGEF1; PRKACA; C2orf88; ARFGEF2; AKAP6; AKAP7; EZR
Function protein kinase binding
Related Protein IRS2; CD24; FBXO5; FOXO3; DPYSL2; CDKN2D; CALM3; BAG5; TRIM6; HDAC4
Function protein serine/threonine/tyrosine kinase activity
Related Protein DSTYK; CLK4; SGK1; PRKAA2; CLK3; AURKB; MAP2K1; AURKA; PRKACA; TNK2
Function ubiquitin protein ligase binding
Related Protein DTX1; RRAGA; NFKBIA; UBE2G2; AKTIP; BAG5; TPI1; UBXN1; USP25; RNF31

Interacting Protein

PRKACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACA here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACA.
PRKAR1A; PRKAR2B; GSK3B; PRKAR2A; PRKAR1B; LRRK2