Prss2
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Official Full Name
protease, serine, 2 (trypsin 2)
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Overview
Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It is found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is activated by enteropeptidase, which is found in the intestinal mucosa, to form trypsin. Once activated, the trypsin can activate more trypsinogen into trypsin. Trypsin cleaves peptide bond on carboxyl side of basic amino acids. Serum trypsinogen is measured using a blood test. High levels are seen in acute pancreatitis, and cystic fibrosis. -
Synonyms
PRSS2 protease, serine, 2; PRSS2; TRYP; 8 anionic trypsin; pancreatic anionic trypsinogen; NP_777115.1; EC 3.4.21.4; Trypsinogen;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- NS0
- Yeast
- C
- His
- His (Fc)
- Avi
- His|T7
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Prss2 Related Articles
- Prss2 Related Research Area
Prss2 involved in several pathways and played different roles in them. We selected most pathways Prss2 participated on our site, such as Neuroactive ligand-receptor interaction, Pancreatic secretion, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prss2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neuroactive ligand-receptor interaction | TAAR12G;GRIA2B;P2RY4;PRL;GABRG1;GALR2;GABRR2;GLRA2;S1PR2 |
Pancreatic secretion | CELA3B;BST1;CCKAR;CLCA2;PLA2G10;ITPR1;RAC1;LOC780933;PLA2G2E |
Protein digestion and absorption | SLC16A10;SLC8A2;CELA2A;SLC1A1;SLC3A1;PRSS1;PRSS2;ATP1A2;ATP1A4 |
Influenza A | IFNA10;MX1;IFNGR1;MAPK9;BLB2;IVNS1ABP;IFNAR2;TNFRSF10D;HSPA8 |
Prss2 has several biochemical functions, for example, calcium ion binding, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Prss2 itself. We selected most functions Prss2 had, and list some proteins which have the same functions with Prss2. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | CAPN2A;MYLZ3;SPATA21;ELTD1;PCDH2G8;NCS1;MYL1;NID2;PCDH1A6 |
protein binding | HLA-A;HIST1H4A;PCDH18;SNRPE;SYT4;SCAMP1;ULK1;FEZ1;PALB2 |
serine-type endopeptidase activity | TMPRSS4B;PREP;HTRA3;PRSS59.1;IMMP1L;PIK3IP1;FURINB;GZMF;FURINA |
Prss2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prss2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Prss2.
- Q&As
- Reviews
Q&As (6)
Ask a questionDrug development for PRSS2 is currently in clinical trials, including monoclonal antibodies against the PRSS2 receptor and inhibitors against the PRSS2 signaling pathway.
Studies have shown that PRSS2 protein can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.
PRSS2 protein plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.
Studies have shown that PRSS2 protein may be associated with the development of cardiovascular diseases such as atherosclerosis and myocardial infarction.
There is no direct way to increase the expression level of PRSS2 protein, but it can be improved by regulating gene expression and providing nutritional support.
In clinical practice, the expression level of PRSS2 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen.
Customer Reviews (3)
Write a reviewGood stability and consistency in the process of mass production.
PRSS2 has an excellent expression system.
PRSS2 has long-lasting effects and sustained release performance.
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