prss2
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  • Official Full Name
  • protease, serine, 2 (trypsin 2)
  • Background
  • Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It is found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is activated by enteropeptidase, which is found in the intestinal mucosa, to form trypsin. Once activated, the trypsin can activate more trypsinogen into trypsin. Trypsin cleaves peptide bond on carboxyl side of basic amino acids. Serum trypsinogen is measured using a blood test. High levels are seen in acute pancreatitis, and cystic fibrosis.
  • Synonyms
  • PRSS2 protease, serine, 2; PRSS2; TRYP; 8 anionic trypsin; pancreatic anionic trypsinogen; NP_777115.1; EC 3.4.21.4; Trypsinogen
Cat.#:PRSS2-2690RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat PRSS2 Protein (24-246 aa), His-tagged
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Cat.#:PRSS2-6BTag:N/A
Source (Host):Species:Bovine
Product nameRecombinant Bovine Trypsin
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Cat.#:PRSS2-316HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Protease, Serine, 2 (Trypsin 2) , His-tagged
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Cat.#:PRSS2-7091HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRSS2 protein, His & T7-tagged
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Cat.#:PRSS2-850HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRSS2
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Cat.#:Prss2-7092MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prss2 protein, His-tagged
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Cat.#:Prss2-909MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Prss2, His tagged
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Cat.#:PRSS2-4739RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRSS2 Protein
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Cat.#:PRSS2-3637RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRSS2 Protein, His-tagged
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Cat.#:PRSS2-6936CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRSS2
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Cat.#:PRSS2-2293MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PRSS2 cell lysate
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Involved Pathway

Prss2 involved in several pathways and played different roles in them. We selected most pathways Prss2 participated on our site, such as Neuroactive ligand-receptor interaction, Pancreatic secretion, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prss2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
TAAR10C; P2RX3A; PTH2R; DRD4B; FPR3; TAAR10D; GHRA; P2RY6; TRY; MC5RA
Pancreatic secretion
PRKCB; RAB27B; CELA3B; ATP1B1; TPCN2; RAB11A; ATP1A3; PLCB3; AMY2A; AMY2B
Protein digestion and absorption
COL7A1; COL21A1; CELA2A; SLC15A1; CELA3A; SLC3A1; COL6A6; SLC1A5; ELN; SLC8A1
Influenza A
MAP2K3; NFKBIA; IL1A; FDPS; IL12B; HLA-DQA1; CASP1; AGFG1; IFNA4; IFNA13

Protein Function

Prss2 has several biochemical functions, for example, calcium ion binding, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Prss2 itself. We selected most functions Prss2 had, and list some proteins which have the same functions with Prss2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PKD1L3; SCIN; S100A16; ANXA3A; PCDH2AB6; ITSN2A; ICN; S100Z; PADI2; ANXA10
Function protein binding
Related Protein DLX2; THOP1; CUL3; SPRY1; FAF2; TWSG1; SIK2; ATG13; ACVR2B; TRIM31
Function serine-type endopeptidase activity
Related Protein TMPRSS11F; LOC100686744; C1RA; TMPRSS15; OVCH2; HTRA2; MASP2; PCSK7; F12; F2

Prss2 Related Articles

Lin, JJ; Zhao, DM; et al. Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:146-156(2015).
Mounzer, R; Whitcomb, DC; et al. Genetics of acute and chronic pancreatitis. CURRENT OPINION IN GASTROENTEROLOGY 29:544-551(2013).