ptk2
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  • Official Full Name
  • protein tyrosine kinase 2
  • Background
  • Focal adhesion kinase subfamily consists of the non-receptor proline-rich protein tyrosine kinases (PTKs). Two members of the family are focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). These two kinases have molecular mass between 110-125 kDa and are closely related in their structure. The presence
    of two proline-rich motifs within the C-terminal domains is conserved. FAK is a nonreceptor and nonmembrane associated PTK which does not contain Src homology 2 (SH2) or SH3 protein interaction domains. The centrally located kinase domain of FAK is flanked by large N- and C-terminal noncatalytic domains. FAK links integrin receptors to intracellular signaling pathways that are important for cell growth, survival, and migration. Integrin receptor engagement with ligands such as fibronectin can stimulate FAK autophosphorylation which enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways. Recent study reveals that FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice.
  • Synonyms
  • PTK2; protein tyrosine kinase 2; FAK; FADK; FAK1; FADK 1; FRNK; PPP1R71; pp125FAK; Protein-tyrosine kinase 2; focal adhesion kinase 1; FADK 1; FAK-related non-kinase polypeptide; protein phosphatase 1, regulatory subunit 71; P_001186578.1; EC 2.7.10.2; EC 2.7.10; NP_005598.3; EC 2.7.10.2; NP_722560.1; OTTHUMP00000226325; OTTHUMP00000226326; OTTHUMP00000226334; OTTHUMP00000226350; OTTHUMP00000226586; OTTHUMP00000226318; OTTHUMP00000226320
Cat.#:PTK2-1272CTag:GST
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken PTK2 Protein (376-683 aa), GST-tagged
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Cat.#:PTK2-1901HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged
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Cat.#:PTK2-28820THTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2
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Cat.#:PTK2-309HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged, Active
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Cat.#:PTK2-38HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2, GST-tagged
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Cat.#:PTK2-44HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PTK2 protein, Flag-tagged, Biotinylated
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Cat.#:PTK2-600HTag:His
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PTK2, His-tagged
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Cat.#:PTK2-6827HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTK2 protein, His & T7-tagged
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Cat.#:PTK2-90HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTK2 protein, MYC/DDK-tagged
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Cat.#:PTK2-13657MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTK2 Protein
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Cat.#:PTK2-4822RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTK2 Protein
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Cat.#:PTK2-6985CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTK2
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Cat.#:PTK2-2700HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PTK2 293 Cell Lysate
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Cat.#:PtK2-1434MTag:N/A
Source (Host):Species:Marsupials
Product namePtK2 (Marsupial kidney) whole cell lysate
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Involved Pathway

PTK2 involved in several pathways and played different roles in them. We selected most pathways PTK2 participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PAK2A; PLCG1; PRKCA; PAK3; PIK3CG; CAMK2D1; PAK1; CAMK2A; PIK3CA; HRASA
Chemokine signaling pathway
MAP2K1; PAK1; CCL19; IKBKB; CX3CL1; JAK3; SHC4; CCL27; GRK1; PRKCZ
PIK-Akt signaling pathway
IFNA2; ITGA4; PPP2CA; COL24A1; COL4A1; TP53; CASP9; RHEB; TCL1A; IL3RA
Axon guidance
TRPC5; CAP2; PPP3CA; NCK2; CSF2RA; GPC1B; CSF2RB; ROBO2; EPHA1; DCC
VEGF signaling pathway
MAPK12; MAPKAPK2; RAC2; SPHK2; RAC1B; RAC1A; PRKCBB; PPP3CCB; MAPK12B; VEGFAB
Focal adhesion
SRC; CDC42; MAPK10; THBS4; COL5A2; ITGA9; MYLK4; PTEN; PPP1R12B; COL5A1
Leukocyte transendothelial migration
MMP2; CLDN8; MAPK12; MYL7; ITGB2; NOX1; PRKCG; MYL10; CLDN7; AASS
Regulation of actin cytoskeleton
LIMK1A; PPP1R12A; CFL2L; RASSF7; PTK2AA; PAK3; CYFIP2; PIP5K1C; CFL2; SSH1
Bacterial invasion of epithelial cells
SHC2; SEPT1; BCAR1; DNM1; VCL; CTTN; CTNNA2; CLTC; CRKL; ARPC4
Amoebiasis
COL4A5; SERPINB10; ADCY1; RAB7; RAB5C; COL27A1; CTSG; PRKCG; PIK3R5; COL1A1
Pathways in cancer
FGF3; GNG3; BIRC8; PIK3CA; BMP4; BID; FGF21; VEGFC; FH; VEGFB
Transcriptional misregulation in cancer
ITGAM; TSPAN7; SMAD1; TLX3; IGF1; ARNT2; PAX8; IGF1R; HIST1H3E; BCL2L1
Proteoglycans in cancer
VAV2; PIK3R3; WNT7A; PIK3R1; PDPK1; WNT5A; ITPR3; ACTG1; NUDT16L1; PLCG1
Small cell lung cancer
MAX; TRP53; PIK3R1; RELA; CCNE1; PTGS2; LAMA3; RXRB; PIK3R5; PIK3CD

Protein Function

PTK2 has several biochemical functions, for example, ATP binding, JUN kinase binding, SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2 itself. We selected most functions PTK2 had, and list some proteins which have the same functions with PTK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein FKBP4; RNASEL; TUT1; UBE2I; HSPA1B; XRCC3; MYO5B; MKNK2B; MAP4K3; HARS2
Function JUN kinase binding
Related Protein GSTP1; PTK2; SPAG9; MAD2L2; MAPK8IP3; SPAG9A
Function SH2 domain binding
Related Protein PTK2; DLC1; CRK; TRPV4; GNB2L1; DAG1; SQSTM1; NUP62; LAX1; SRC
Function actin binding
Related Protein PLEC; PPP1R9B; FMNL2; DAAM1; SNTA1; MKL1; MYOZ2; VCL; PARVAB; NEXN
Function non-membrane spanning protein tyrosine kinase activity
Related Protein Fert2; YES1; BMX; MATK; STK16; RIPK2; PRKCD; SRC; TXK; BAZ1B
Function protein binding
Related Protein ADRA2B; MSX2; STX1A; STAG2; SOX7; PIM1; IFIT1; GAPDHS; C9orf142; UCP3
Function protein kinase activity
Related Protein ACVR1; PTK6B; TRIO; CAMK2B1; MAP2K2A; GSK3AB; ANKK1; ERBB3B; RIPK1L; CSF1RA
Function protein kinase binding
Related Protein PTPN6; CYLD; PPP1R12B; CALM; GRB7; ATP1A1; CD4; CCNA2; PLCG1; RELA
Function protein tyrosine kinase activity
Related Protein ZNF143B; KIT; MATK; EPHB3A; INSRA; INSRB; IGF1RA; LCK; RET; DYRK1B
Function receptor binding
Related Protein DAO; FYNA; Ar; HNF4A; MCHR1; TNFSF4; NPFFL; HLA-E; NUDT19; WNT7A
Function signal transducer activity
Related Protein TAAR1B; OLFR15; FPR-RS3; RASGRP3; TAAR7A; OR103-4; GMFB; TMTOPS3B; TRHR2; VMN1R52

Interacting Protein

PTK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2.
SRC; PXN

PTK2 Related Articles

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Weisser, M; Yeh, RF; et al. PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia. BLOOD 124:420-425(2014).