ptk2
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  • Official Full Name
  • protein tyrosine kinase 2
  • Background
  • Focal adhesion kinase subfamily consists of the non-receptor proline-rich protein tyrosine kinases (PTKs). Two members of the family are focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). These two kinases have molecular mass between 110-125 kDa and are closely related in their structure. The presence
    of two proline-rich motifs within the C-terminal domains is conserved. FAK is a nonreceptor and nonmembrane associated PTK which does not contain Src homology 2 (SH2) or SH3 protein interaction domains. The centrally located kinase domain of FAK is flanked by large N- and C-terminal noncatalytic domains. FAK links integrin receptors to intracellular signaling pathways that are important for cell growth, survival, and migration. Integrin receptor engagement with ligands such as fibronectin can stimulate FAK autophosphorylation which enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways. Recent study reveals that FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice.
  • Synonyms
  • PTK2; protein tyrosine kinase 2; FAK; FADK; FAK1; FADK 1; FRNK; PPP1R71; pp125FAK; Protein-tyrosine kinase 2; focal adhesion kinase 1; FADK 1; FAK-related non-kinase polypeptide; protein phosphatase 1, regulatory subunit 71; P_001186578.1; EC 2.7.10.2; EC 2.7.10; NP_005598.3; EC 2.7.10.2; NP_722560.1; OTTHUMP00000226325; OTTHUMP00000226326; OTTHUMP00000226334; OTTHUMP00000226350; OTTHUMP00000226586; OTTHUMP00000226318; OTTHUMP00000226320
Cat.#:PTK2-1901HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged
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Cat.#:PTK2-28820THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2
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Cat.#:PTK2-309HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged, Active
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Cat.#:PTK2-38HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2, GST-tagged
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Cat.#:PTK2-44HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PTK2 protein, Flag-tagged, Biotinylated
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Cat.#:PTK2-600HTag:His
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PTK2, His-tagged
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Cat.#:PTK2-6827HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTK2 protein, His & T7-tagged
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Cat.#:PTK2-90HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTK2 protein, MYC/DDK-tagged
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Cat.#:PTK2-13657MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTK2 Protein
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Cat.#:PTK2-4822RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTK2 Protein
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Cat.#:PTK2-6985CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTK2
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Cat.#:PTK2-2700HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTK2 293 Cell Lysate
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Cat.#:PtK2-1434MTag:
Source (Host):Species:Marsupials
Product namePtK2 (Marsupial kidney) whole cell lysate
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Involved Pathway

PTK2 involved in several pathways and played different roles in them. We selected most pathways PTK2 participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
GAB1; PAK6B; PIK3R3A; HRASB; EREG; MAP2K7; ARAF; EGFRA; PIK3CA; NCK2A
Chemokine signaling pathway
GNG5; CCL4; CCL14; PREX1; CCL11; SHC1; IKBKB; Adcy4; PTK2; BRAF
PIK-Akt signaling pathway
IBSP; FLT4; PPP2R3C; HSP90AA1; IL6; GHR; CD19; GNGT2; IFNA7; GNG11
Axon guidance
DUSP9; RASA1; RASGEF1A; RGMB; EPHB4; SPTBN2; SEMA3D; SEMA4C; UNC5C; JAK1
VEGF signaling pathway
PPP3R2; MAPK12; PPP3CCB; RAC1; AKT1; MAPK14A; RAC3; MAPK1; SPHK1; MAPK11
Focal adhesion
ITGB1; COL11A1A; COL6A3; MYLK3; VASP; ACTN3; PARVAA; CAPN2B; PPP1R12A; EGFRA
Leukocyte transendothelial migration
CLDN1; ITGB1; PIK3R3; ITGA4; CYBB; ACTG1; CLDN18; JAM3; ICAM1; RHOH
Regulation of actin cytoskeleton
MLCK2; LIMK1; MAPK6; PAK2A; GSNB; VAV1; PPP1CAA; PAK7; FGF8A; ITGAV
Bacterial invasion of epithelial cells
CDC42; PIK3CB; CLTC; MAD2L2; PIK3R5; SEPT1; CLTA; BCAR1; RAC1; WASF1
Amoebiasis
CTSG; COL5A1; MUC2; AASS; PIK3R5; IFNG; NFKB1; IL6; PRKACA; CD1d1
Pathways in cancer
F2R; LAMA2; GNGT2; SPI1; FGF9; RALB; FH; RARA; CCDC6; PIK3R5
Transcriptional misregulation in cancer
ETV1; PROM1; MLF1; IGF1; WNT16; CD40; BCL2A1A; RUNX1; SP1; EWSR1
Proteoglycans in cancer
SMAD2; AKT2; ITGAV; WNT2; PPP1R12C; HOXD10; MAPK3; CBL; ELK1; TWIST1
Small cell lung cancer
RELA; AKT1; BIRC3; PTGS2; LAMA3; LAMB2; LAMA1; BCL2L1; PIK3CD; BIRC7

Protein Function

PTK2 has several biochemical functions, for example, ATP binding, JUN kinase binding, SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2 itself. We selected most functions PTK2 had, and list some proteins which have the same functions with PTK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBA6; CCT6B; UHMK1; DDX4; KIF17; UBE2Z; GALK2; SPATA5; AURKB; ACTC1A
Function JUN kinase binding
Related Protein MAD2L2; MAPK8IP3; GSTP1; SPAG9A; PTK2; SPAG9
Function SH2 domain binding
Related Protein GNB2L1; LILRB1; MS4A2; SRC; SYP; SH3PXD2B; CRK; PTK2; JAK2; DLC1
Function actin binding
Related Protein MYO10; PPP1R9B; NF2; KPTN; MYBPC3; WASF1; MYO5B; CAMK2B; CFL2L; SPTBN2
Function non-membrane spanning protein tyrosine kinase activity
Related Protein PRKCD; MELK; TNK1; PTK2BB; PTK2; CLK1; FRK; PTK2B; STYK1; SYK
Function protein binding
Related Protein SMAD3B; GLYCTK; DSC2; SYMPK; GNB1B; HEY2; SAP18; P4HA2; SLC1A2; CRHR2
Function protein kinase activity
Related Protein CDK1; PRKAB1; STK24; RAF1; CDK5; CCL3; PRKCZ; BMPR1AB; AKT3A; FASTKD1
Function protein kinase binding
Related Protein MAP3K13; FAM83B; AKAP7; MAP3K2; STXBP1; PEBP1; MAP3K5; CDK5; MAPKAP1; ADCY6
Function protein tyrosine kinase activity
Related Protein SRC; BAZ1B; MAP2K5; FGFR4; FER; FGR; MAP2K7; PTK2AA; KIT; CSK
Function receptor binding
Related Protein PTK2AA; CXCL10; PLXNC1; IDH1; LTA; INSL4; ADIPOQ; PVRL1A; PDGFRB; CXCL1
Function signal transducer activity
Related Protein MAPKAPK2A; GNG3; OPN1MW3; PLCD1A; TRADD; TAAR2; MRGPRB5; OLFR469; TAAR12J; GNAI2A

Interacting Protein

PTK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2.
SRC; PXN

PTK2 Related Articles

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Weisser, M; Yeh, RF; et al. PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia. BLOOD 124:420-425(2014).