ptk2
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  • Official Full Name
  • protein tyrosine kinase 2
  • Background
  • Focal adhesion kinase subfamily consists of the non-receptor proline-rich protein tyrosine kinases (PTKs). Two members of the family are focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). These two kinases have molecular mass between 110-125 kDa and are closely related in their structure. The presence
    of two proline-rich motifs within the C-terminal domains is conserved. FAK is a nonreceptor and nonmembrane associated PTK which does not contain Src homology 2 (SH2) or SH3 protein interaction domains. The centrally located kinase domain of FAK is flanked by large N- and C-terminal noncatalytic domains. FAK links integrin receptors to intracellular signaling pathways that are important for cell growth, survival, and migration. Integrin receptor engagement with ligands such as fibronectin can stimulate FAK autophosphorylation which enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways. Recent study reveals that FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice.
  • Synonyms
  • PTK2; protein tyrosine kinase 2; FAK; FADK; FAK1; FADK 1; FRNK; PPP1R71; pp125FAK; Protein-tyrosine kinase 2; focal adhesion kinase 1; FADK 1; FAK-related non-kinase polypeptide; protein phosphatase 1, regulatory subunit 71; P_001186578.1; EC 2.7.10.2; EC 2.7.10; NP_005598.3; EC 2.7.10.2; NP_722560.1; OTTHUMP00000226325; OTTHUMP00000226326; OTTHUMP00000226334; OTTHUMP00000226350; OTTHUMP00000226586; OTTHUMP00000226318; OTTHUMP00000226320
Cat.#:PTK2-1901HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged
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Cat.#:PTK2-28820THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2
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Cat.#:PTK2-309HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged, Active
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Cat.#:PTK2-38HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2, GST-tagged
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Cat.#:PTK2-44HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PTK2 protein, Flag-tagged, Biotinylated
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Cat.#:PTK2-600HTag:His
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PTK2, His-tagged
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Cat.#:PTK2-6827HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTK2 protein, His & T7-tagged
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Cat.#:PTK2-90HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTK2 protein, MYC/DDK-tagged
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Cat.#:PTK2-13657MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTK2 Protein
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Cat.#:PTK2-4822RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTK2 Protein
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Cat.#:PTK2-6985CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTK2
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Cat.#:PTK2-2700HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTK2 293 Cell Lysate
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Cat.#:PtK2-1434MTag:
Source (Host):Species:Marsupials
Product namePtK2 (Marsupial kidney) whole cell lysate
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Involved Pathway

PTK2 involved in several pathways and played different roles in them. We selected most pathways PTK2 participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PLCG1; AKT2; PAK2; AKT2L; PAK2B; CAMK2D2; CAMK2A; PAK7; MYCB; MAP2K4B
Chemokine signaling pathway
ADRBK2; PIK3R1; CXCL3; PAK1; CXCR3; RHOA; GRK6; GNG8; PRKCZ; PRKCD
PIK-Akt signaling pathway
PIK3R5; TCL1B; LAMB3; RAF1; ITGB1; CCND1; GRB2; G6PC; ITGB4; PIK3R1
Axon guidance
PAK7; NCK2; HRAS; RGMA; PPP3CB; RAC2; ARHGEF28; NETO2; EFNA5; SEMA6D
VEGF signaling pathway
RAC3A; VEGFA; RAC1; PXNA; RAF1B; MAP2K2; PRKCB; PIK3R2; PPP3R1B; PPP3CB
Focal adhesion
PIK3R5; SRC; TNC; THBS4B; CAV2; PARVG; CHAD; ITGB1B.2; COL6A1; LAMC2
Leukocyte transendothelial migration
CDH5; MAPK13; ACTN3; EZR; PTPN11; ACTG1; NOX3; PRKCG; ITGB2L; GNAI1
Regulation of actin cytoskeleton
PIP5K2; ARHGAP35; GNA13A; DIAPH1; RHOAB; MYL5; EGFRA; FGF18; MYL9A; CDC42
Bacterial invasion of epithelial cells
SRC; ELMO1; MAD2L2; PIK3CA; ILK; PIK3CD; CD2AP; ELMO3; ACTG1; CTNNA3
Amoebiasis
PRKACB; COL1A1; IL12B; RAB7; VCL; LAMC3; SERPINB2; GNAL; SERPINB3; ARG1
Pathways in cancer
CSF3R; BMP4; CCNE2; TPM3; RXRG; Fasl; Ar; WNT7B; STAT1; FZD2
Transcriptional misregulation in cancer
CCNT2; HIST1H3A; HIST1H3I; FEV; CLSTN2; IL2RB; SSX1; MLF1; ERG; MDM2
Proteoglycans in cancer
FN1; WNT8B; TRP53; WNT9A; ANK2; ELK1; ESR1; SDC4; ROCK1; NANOG
Small cell lung cancer
TRAF6; PIK3R3; PIK3R2; PIK3CB; IKBKG; AKT2; RXRA; ITGA2B; PTGS2; TRAF3

Protein Function

PTK2 has several biochemical functions, for example, ATP binding, JUN kinase binding, SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2 itself. We selected most functions PTK2 had, and list some proteins which have the same functions with PTK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX17; NPR1; MTHFD1L; SLFN5; PINK1; ABCC9; CHORDC1; IRAK4; ABCA8; NMNAT3
Function JUN kinase binding
Related Protein MAD2L2; SPAG9A; MAPK8IP3; PTK2; GSTP1; SPAG9
Function SH2 domain binding
Related Protein ARHGAP5; SYP; PTK2; SYNGR3; NLK; DLC1; SQSTM1; CTR9; LCK; LILRB1
Function actin binding
Related Protein SMYHC1; PARVB; ABRAB; KLHL1; TPM1; DST; MTSS1LA; DAAM1B; NF2A; ABLIM3
Function non-membrane spanning protein tyrosine kinase activity
Related Protein TNK2; PTK2AB; ZNF143B; JAK2B; CSK; SRC; PTK6B; JAK3; TEC; JAK1
Function protein binding
Related Protein DUSP15; CYHR1; SGK1; WDR20; UBXN1; FBXW8; TRAPPC5; GK; CYTIP; FAM111A
Function protein kinase activity
Related Protein CAMK2G1; AVP; TESK2; SBK1; CAMK2B1; TRIO; Fert2; NTRK3A; PLK5; DYRK1A
Function protein kinase binding
Related Protein HSPB1; PTPN6; SFN; Cd24a; PPP1CC; SV2A; RB1CC1; DPYSL2; TSACC; SPRED2
Function protein tyrosine kinase activity
Related Protein FER; TNK1; HCK; TYRO3; TESK2; TTK; JAK3; DYRK4; INSRA; ZAP70
Function receptor binding
Related Protein STRAP; HAMP; FGF6B; SCYL2; UFD1L; ANGPT2; MTSS1; RASA1; CCL17; PLG
Function signal transducer activity
Related Protein IRS4; MRGPRA5; GNAQ; OLFR154; AVP; DRD1B; OPN4XA; OLFR469; RGS7; ADORA2AB

Interacting Protein

PTK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2.
SRC; PXN

PTK2 Related Articles

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Weisser, M; Yeh, RF; et al. PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia. BLOOD 124:420-425(2014).