ptpn1
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  • Official Full Name
  • protein tyrosine phosphatase, non-receptor type 1
  • Background
  • PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and may be a potential therapeutic target for diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B.
  • Synonyms
  • PTPN1; protein tyrosine phosphatase, non-receptor type 1; PTP1B; tyrosine-protein phosphatase non-receptor type 1; protein tyrosine phosphatase 1B; protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental
Cat.#:PTPN1-1521HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN1
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Cat.#:PTPN1-1908HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Tyrosine Phosphatase, Non-Receptor Type 1, GST-tagged
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Cat.#:PTPN1-220HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTPN1 protein, DDK-tagged
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Cat.#:PTPN1-221HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN1 protein, His-tagged
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Cat.#:PTPN1-31256THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN1 protein, Bioactivity Validated
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Cat.#:PTPN1-764HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN1, His tagged
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Cat.#:PTPN1-13674MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTPN1 Protein
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Cat.#:PTPN1-4829RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTPN1 Protein
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Cat.#:PTPN1-3704RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTPN1 Protein, His-tagged
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Cat.#:PTPN1-6438CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTPN1
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Cat.#:PTPN1-8565ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PTPN1
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Cat.#:PTPN1-537HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN1
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Cat.#:Ptpn1-455MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptpn1, GST-tagged
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Cat.#:Ptpn1-456RTag:GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ptpn1, GST-tagged
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Cat.#:PTPN1-460HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTPN1, GST-tagged, Active
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Cat.#:PTPN1-1517HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN1 (Active), GST-tagged
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Cat.#:PTPN1-2686HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTPN1 293 Cell Lysate
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Involved Pathway

PTPN1 involved in several pathways and played different roles in them. We selected most pathways PTPN1 participated on our site, such as Adherens junction, Insulin signaling pathway, Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junction
WASF3B; SSX2IPA; WASB; SMAD2; ACTB1; FGFR1; RAC1B; TGFBR2; CSNK2A2; WASLB
Insulin signaling pathway
HRAS; PDPK1; PIK3R3B; TSC1; FBP2; CBLB; SHC2; PRKAG2A; IRS2; PPP1CAB
Insulin resistance
ACACB; G6PC2; RPS6KA3A; SLC2A2; INSB; GFPT1; PPP2R4; NFKBIAA; GSK3B; PTPRFB

Protein Function

PTPN1 has several biochemical functions, for example, enzyme binding, ephrin receptor binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN1 itself. We selected most functions PTPN1 had, and list some proteins which have the same functions with PTPN1. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein YES1; HIST1H2AG; RCOR3; ESR1; PEX5; BACE1; CBX1; HAND1; TUT1; NPM2
Function ephrin receptor binding
Related Protein SHC1; FYN; CHN1; EFNA5; EPHA4; PTPN1; NTRK3; CRK; EFNA1A; GRB2
Function insulin receptor binding
Related Protein FRS3; DOK7; IGF1R; FRS2B; INSL3; PDPK1; IRS2; SNX4; PHIP; PTPN11
Function poly(A) RNA binding
Related Protein DDX24; PRMT1; DDX23; RPL7A; AGO2; DKC1; HNRPLL; DIEXF; APEH; RBM39
Function protein binding
Related Protein MCM10; SNAP29; CATSPERG2; NCOA5; PLXDC1; NR2C2; FUBP1; PENK; TRAIP; AKR1C1
Function protein kinase binding
Related Protein JTB; PLCG1; FAM83A; GATA4; RPS3; WAS; CDK5RAP1; PXN; PTEN; SKI
Function protein phosphatase 2A binding
Related Protein PTPN1; SPHK1; EIF4EBP1; HMGCR; IGBP1; STRN; SMG5; FOXO1; SHC1; PPP2R2A
Function protein tyrosine phosphatase activity
Related Protein PTPRF; CDC14AA; PGP; PTPN2A; PTPRU; DUSP13A; DUSP23; DUSP4; PTPRNA; MTMR7A
Function receptor tyrosine kinase binding
Related Protein PTPN1; ANGPT2; PIK3R2; SHC3; ELMO2; NRG1; ANGPT2A; PCNA; TRP53; GAS6
Function zinc ion binding
Related Protein FHL1A; SIAH2L; ADH1C; NR2E1; ABLIM1A; LHX2; GRIN2A; RBM5; ZCCHC6; DPF3

Interacting Protein

PTPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN1.
INSR