| Description : |
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
67.8 kDa |
| AA Sequence : |
MTSRRWFHPNITGVEAENLLLTRGV DGSFLARPSKSNPGDFTLSVRRNGA VTHIKIQNTGDYYDLYGGEK FATLAELVQYYMEHHGQLKEKNGDV IELKYPLNCADPTSERWFHGHLSGK EAEKLLTEKGKHGSFLVRES QSHPGDFVLSVRTGDDKGESNDGKS KVTHVMIRCQELKYDVGGGERFDSL TDLVEHYKKNPMVETLGTVL QLKQPLNTTRINAAEIESRVRELSK LAETTDKVKQGFWEEFETLQQQECK LLYSRKEGQRQENKNKNRYK NILPFDHTRVVLHDGDPNEPVSDYI NANIIMPEFETKCNNSKPKKSYIAT QGCLQNTVNDFWRMVFQENS RVIVMTTKEVERGKSKCVKYWPDEY ALKEYGVMRVRNVKESAAHDYTLRE LKLSKVGQGNTERTVWQYHF RTWPDHGVPSDPGGVLDFLEEVHHK QESIMDAGPVVVHCSAGIGRTGTFI VIDILIDIIREKGVDCDIDV PKTIQMVRSQRSGMVQTEAQYRFIY MAVQHYIETLQRRIEEEQKSKRKGH EYTNIKYSLADQTSGDQSPL
PPCTPTPPCAEMREDSARVYENVGL MQQQKSFRTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Phosphatase |
| Protein Pathways : |
Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma |
