ptpra
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  • Official Full Name
  • protein tyrosine phosphatase, receptor type, A
  • Background
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
  • Synonyms
  • PTPRA; protein tyrosine phosphatase, receptor type, A; PTPA, PTPRL2; receptor-type tyrosine-protein phosphatase alpha; HLPR; HPTPA; LRP; RPTPA; PTPase-alpha; PTPLCA-related phosphatase; tyrosine phosphatase alpha; protein-tyrosine phosphatase alpha; prote
Cat.#:PTPRA-3140HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPRA Protein, MYC/DDK-tagged
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Cat.#:PTPRA-1621HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Tyrosine Phosphatase, Receptor Type, A, GST-tagged
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Cat.#:PTPRA-30074THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPRA
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Cat.#:PTPRA-7007HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTPRA, His & GST tagged
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Cat.#:PTPRA-8105HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPRA protein, His & T7-tagged
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Cat.#:Ptpra-8106RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ptpra protein, His & T7-tagged
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Cat.#:PTPRA-6711CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTPRA
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Cat.#:PTPRA-9392ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PTPRA
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Cat.#:PTPRA-1521HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPRA (Active), GST-tagged
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Cat.#:PTPRA-467HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTPRA, GST-tagged, Active
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Cat.#:PTPRA-503HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTPRA cell lysate
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Involved Pathway

PTPRA involved in several pathways and played different roles in them. We selected most pathways PTPRA participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
KBTBD7; HBEGF; CSF2RB; JAK1; NTF7; NRG4; RASGRP4; FGF20A; LAMTOR2; SPTA1
Axon guidance
EFNB2A; SCN3B; PAK7; SEMA5A; SCN2A; COL6A2; KBTBD7; SEMA3E; SEMA3C; EPHB4B
Cytokine Signaling in Immune system
DPF1; IRAK3; SPTB; SPRED3; IRF2; RASGEF1A; TAB1; TRIM29; IFIT11; CSH1
DAP12 interactions
PEA15A; DUSP6; SIGLEC14; FGF20A; DUSP2; SPRED1; PAQR3B; IL17RD; MARK3; SPNA2
DAP12 signaling
GRAP2B; FGF20A; HBEGF; RASGEF1A; NRG2A; PEA15A; FGF18B; DUSP10; FGF10B; NRG3
Developmental Biology
MED23; KALRN; RGMA; KIF4; NKX2.2A; INSM1B; WDR83; NRTN; LIN28A; POU5F3
Downstream signal transduction
FRS3; FGFR1B; FGF20A; AGO2; PAQR3B; CRKL; GRB7; MARK3; FGF18B; RASGEF1A
Downstream signaling of activated FGFR1
IL17RD; RASGEF1A; SPRED2; MARK3; PTPRA; SPRED3; DUSP2; AGO2; RASGRP4; CNKSR1

Protein Function

PTPRA has several biochemical functions, for example, protein binding, protein tyrosine phosphatase activity, transmembrane receptor protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRA itself. We selected most functions PTPRA had, and list some proteins which have the same functions with PTPRA. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein ASB3; HSP90AA1; RAB17; PCSK9; CSRP2; CRHR2; HBXIP; MAB21L3; COPS6; GIP
Function protein tyrosine phosphatase activity
Related Protein PTPN11A; EPM2A; PTPRF; PTPN2; DUSP21; EYA4; PTPN2B; PTPN6; PTENB; PTPN11B
Function transmembrane receptor protein tyrosine phosphatase activity
Related Protein PTPRN2; PTPRS; PTPN6; PTPRR; PTPRG; PTPRM; EVLA; PTPRA; PTPRO; PTPRE

Interacting Protein

PTPRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRA.
GRB2; SRC; SRC; Fyn; UVRAG