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PTPRA

  • Official Full Name

    protein tyrosine phosphatase, receptor type, A

  • Overview

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
  • Synonyms

    PTPRA; protein tyrosine phosphatase, receptor type, A; PTPA, PTPRL2; receptor-type tyrosine-protein phosphatase alpha; HLPR; HPTPA; LRP; RPTPA; PTPase-alpha; PTPLCA-related phosphatase; tyrosine phosphatase alpha; protein-tyrosine phosphatase alpha; prote;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPRA-1521H Active Recombinant Human PTPRA, GST-tagged E.coli GST 174-802 aa
Human PTPRA-467H Recombinant Human PTPRA, GST-tagged, Active Sf9 Insect Cell GST
Human PTPRA-7007H Active Recombinant Human PTPRA protein, His&GST-tagged Insect Cells His/GST Ala174-Lys793
Human PTPRA-8105H Recombinant Human PTPRA protein, His & T7-tagged E.coli His/T7 Trp624~Asn800 (Accession # P18433)
Human PTPRA-503HCL Recombinant Human PTPRA cell lysate Insect Cell N/A
Human PTPRA-2157HFL Recombinant Full Length Human PTPRA Protein, C-Flag-tagged Mammalian cells Flag
Human PTPRA-3140H Recombinant Human PTPRA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTPRA-1803H Recombinant Human PTPRA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTPRA-1703H Recombinant Human PTPRA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPRA-1803H-B Recombinant Human PTPRA Protein Pre-coupled Magnetic Beads HEK293
Human PTPRA-6683H Recombinant Human PTPRA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Ptpra-5243M Recombinant Mouse Ptpra Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Ptpra-8106R Recombinant Rat Ptpra protein, His & T7-tagged E.coli His/T7 Trp618~Lys796 (Accession # Q66HJ7)
Homo sapiens (Human) RFL17537HF Recombinant Full Length Human Receptor-Type Tyrosine-Protein Phosphatase Alpha(Ptpra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-802)
Rattus norvegicus (Rat) RFL18512RF Recombinant Full Length Rat Receptor-Type Tyrosine-Protein Phosphatase Alpha(Ptpra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-796)
Zebrafish PTPRA-9392Z Recombinant Zebrafish PTPRA Mammalian Cell His
Chicken PTPRA-6711C Recombinant Chicken PTPRA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPRA Related Research Area

PTPRA involved in several pathways and played different roles in them. We selected most pathways PTPRA participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationSPRED2;SPTBN2;DUSP4;FGF10B;NRG3;JAK1;PSMD10;DUSP5;FRS2A
Axon guidanceSEMA3C;EFNA1B;NCK1;RASGRP1;MYL12B;PAK6;SPRED1;LRRC4C;TRPC3
Cytokine Signaling in Immune systemJAK3;GBP1;TNIP2;FCGR1B;HBEGF;IFIT14;NRG2A;IFI35;KLB
DAP12 interactionsSPTA1;CD300E;PTPRA;PEA15;LAMTOR2;PAQR3B;AGO3;FRS2A;DUSP4
DAP12 signalingFRS3;AGO2;RASGRP1;MOV10;HBEGF;FGF8B;SPTA1;DUSP4;KBTBD7
Developmental BiologyNKX2.2A;SCN2B;CLTC;LGI3;RHOC;TCF3A;SCN3B;MED9;DUSP5
Downstream signal transductionFGF8B;SPTBN1;SPTB;FGF20A;AGO3;THEM4;SPRED1;FRS2B;GRB7
Downstream signaling of activated FGFR1SPRED3;RASGEF1A;DUSP9;PHB;PAQR3A;SPRED1;PEA15;PTPRA;DAB2IPB

PTPRA has several biochemical functions, for example, protein binding, protein tyrosine phosphatase activity, transmembrane receptor protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRA itself. We selected most functions PTPRA had, and list some proteins which have the same functions with PTPRA. You can find most of the proteins on our site.

Function Related Protein
protein bindingRIPK2;REPS1;TRIM72;PLIN3;SPHK1;CBLN3;SPRR3;TAF9;PRDM10
protein tyrosine phosphatase activityPTPN3;EYA2;PTPN6;PTPN11;MTMR7A;EYA4;PTPN7;DUPD1;DUSP10
transmembrane receptor protein tyrosine phosphatase activityPTPRF;PTPRO;PTPRUB;PTPRN2;PTPRM;PTPRB;PTPRR;PTPRC;PTPRE

PTPRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRA.

GRB2; SRC; SRC; Fyn; UVRAG

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