| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
89.7 kDa |
| AA Sequence : |
MDSWFILVLLGSGLICVSANNATTV APSVGITRLINSSTAEPVKEEAKTS NPTSSLTSLSVAPTFSPNITLGPTY LTTVNSSDSDNGTTRTASTNSIGIT ISPNGTWLPDNQFTDARTEPWEGNS STAATTPETFPPSDETPIIAVMVAL SSLLVIVFIIIVLYMLRFKKYKQAG SHSNSFRLSNGRTEDVEPQSVPLLA RSPSTNRKYPPLPVDKLEEEINRRM ADDNKLFREEFNALPACPIQATCEA ASKEENKEKNRYVNILPYDHSRVHL TPVEGVPDSDYINASFINGYQEKNK FIAAQGPKEETVNDFWRMIWEQNTA TIVMVTNLKERKECKCAQYWPDQGC WTYGNIRVSVEDVTVLVDYTVRKFC IQQVGDMTNRKPQRLITQFHFTSWP DFGVPFTPIGMLKFLKKVKACNPQY AGAIVVHCSAGVGRTGTFVVIDAML DMMHTERKVDVYGFVSRIRAQRCQM VQTDMQYVFIYQALLEHYLYGDTEL EVTSLETHLQKIYNKIPGTSNNGLE EEFKKLTSIKIQNDKMRTGNLPANM KKNRVLQIIPYEFNRVIIPVKRGEE NTDYVNASFIDGYRQKDSYIASQGP LLHTIEDFWRMIWEWKSCSIVMLTE LEERGQEKCAQYWPSDGLVSYGDIT VELKKEEECESYTVRDLLVTNTREN KSRQIRQFHFHGWPEVGIPSDGKGM ISIIAAVQKQQQQSGNHPITVHCSA GAGRTGTFCALSTVLERVKAEGILD VFQTVKSLRLQRPHMVQTLEQYEFC YKVVQEYIDAFSDYANFKTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
