ptprc
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  • Official Full Name
  • protein tyrosine phosphatase, receptor type, C
  • Background
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
  • Synonyms
  • PTPRC; protein tyrosine phosphatase, receptor type, C; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide;
Cat.#:PTPRC-133HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human PTPRC Protein, His-tagged
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Cat.#:PTPRC-655HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPRC Protein (Met1-Lys529), His-tagged
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Cat.#:PTPRC-1622HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Tyrosine Phosphatase, Receptor Type, C, His-tagged
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Cat.#:Ptprc-1623MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Protein Tyrosine Phosphatase, Receptor Type, C, GST-tagged
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Cat.#:PTPRC-186HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPRC Protein, DDK/His-tagged
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Cat.#:PTPRC-230HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPRC, Fc tagged
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Cat.#:PTPRC-231HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPRC, StrepII-tagged
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Cat.#:PTPRC-232HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPRC, StrepII-tagged
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Cat.#:PTPRC-27135THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PTPRC, His-tagged
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Cat.#:PTPRC-3046HCLTag:Myc|DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human PTPRC cell lysate
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Cat.#:PTPRC-4265HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Tyrosine Phosphatase, Receptor Type, C
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Cat.#:PTPRC-480HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human protein tyrosine phosphatase, receptor type, C, His-tagged
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Cat.#:PTPRC-480MTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Ptprc, DDDDK tagged
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Cat.#:Ptprc-550MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ptprc, Fc tagged
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Cat.#:Ptprc-5759MTag:His|S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptprc protein, His & S-tagged
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Cat.#:Ptprc-684MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Ptprc, His-tagged
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Cat.#:Ptprc-8677MTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Ptprc, His & GST tagged
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Cat.#:PTPRC-4838RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTPRC Protein
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Cat.#:PTPRC-5987CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTPRC
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Cat.#:PTPRC-1522HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTPRC (Active), His-tagged
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Cat.#:PTPRC-468HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPRC, GST-tagged, Active
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Cat.#:PTPRC-671HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTPRC, His-tagged
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Cat.#:PTPRC-3045HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPRC cell lysate
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Cat.#:PTPRC-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse PTPRC cell lysate
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Cat.#:PTPRC-1141MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PTPRC cell lysate
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Cat.#:CDA089PTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD-45
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Involved Pathway

PTPRC involved in several pathways and played different roles in them. We selected most pathways PTPRC participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
CLDN4; BMA2; CLDN11B; CD4; MHC2DAB; CLDN11A; MHC2DCB; VTCN1; ESAM; CLDN18
T cell receptor signaling pathway
PAK3; MAP2K1; KRAS; RHOA; NRAS; NFKBIA; CD3E; VAV2; PIK3CA; MAP2K7
Fc gamma R-mediated phagocytosis
SYK; FCGR1A; PLA2G4F; PLCG2; CFL1; PIK3CD; SPHK1; PRKCD; PIK3R5; RAC2
Primary i
RFX5; LCK; IL7R; CD4; BTK; CD8B1; BLNK; CD3E; AIRE; TAP1
nodeficiency
ORAI1; RAG1; TNFRSF13B; IL7R; CD19; IGLL1; RFX5; IL2RG; CD3E; BLNK

Protein Function

PTPRC has several biochemical functions, for example, protein binding, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRC itself. We selected most functions PTPRC had, and list some proteins which have the same functions with PTPRC. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein LCE3E; RPA2; NIPAL3; ZNF792; TSSK3; LGALS3; SMIM3; TMEM183A; DALRD3; CXorf48
Function protein kinase binding
Related Protein MAP3K5; AXIN1; CEP68; CDC25A; CCNL1A; DNM1; DVL1; GHR; JIP1; PTEN
Function protein tyrosine phosphatase activity
Related Protein TIMM50; EYA1; MTM1; MTMR14; DUSP13; PTPN11; PTPN4A; PTPRJ; PTPRR; PTPMT1
Function transmembrane receptor protein tyrosine phosphatase activity
Related Protein PTPRC; PTPRD; PTPRS; PTPRB; PTPRN2; PTPN6; PTPRM; PTPRG; PTPRUB; PTPRE

Interacting Protein

PTPRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRC here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRC.
LCK; CSK; CTNNB1; LGALS1; ITGAL; PDPK1; EGFR; ERBB2

PTPRC Related Articles

Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).
Aspinall-O'Dea, M; Pierce, A; et al. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. NATURE PROTOCOLS 10:149-168(2015).