rac2
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  • Official Full Name
  • ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
  • Background
  • The Rho family of GTPases or small G-proteins, most Rho, and Cdc42, are all implicated in different aspects of regulation of cytoskeletal signaling when in their GTP-bound active state. Rac, Rho and Cdc42 encompass the assembly of actin-based structures such as lamellipodia, stress fibers, and filopodia, respectively. Together they help control the organization of the actin cytoskeleton, proliferation, apoptosis, membrane transport and gene expression. Rac, Cdc42, and Rho work in concert with one a involved in lamellipodia formation,Works with Cdc42,Involved in cell polarization and filopodia formation, through their downstream targets WAVE and WASP, respectively, that signal through the Arp2/3 complex to the actin cytoskeleton. This signaling enables the coordination of cell migration at the leading edge by inducing the migrating cell to stimulate actin-mediated membrane protrusion. The downstream target of Rac,WAVE-1, functions as a scaffolding protein that directs actin reorganization by relaying signals from Rac to the Arp2/3 complex. The continued addition of actin monomers in this branched network is thought to provide the driving force for the extension of the membrane that occurs during lamellipodial protrusion.
  • Synonyms
  • RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); ras-related C3 botulinum toxin substrate 2; EN 7; p21-Rac2; small G protein; rho family, small GTP binding protein Rac2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Gx; EN-7; HSPC022
Cat.#:RAC2-2148HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC2, GST-tagged
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Cat.#:RAC2-2549HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC2, His tagged
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Cat.#:RAC2-486HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC2
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Cat.#:RAC2-13858MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAC2 Protein
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Cat.#:RAC2-3770RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RAC2 Protein, His-tagged
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Cat.#:RAC2-4492CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAC2
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Cat.#:RAC2-295ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAC2
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Cat.#:RAC2-526HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAC2 lysate
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Involved Pathway

RAC2 involved in several pathways and played different roles in them. We selected most pathways RAC2 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
HSPA6; FGF11; GADD45G; NGF; PRKACAB; CACNA2D1; FLNC; GRB2A; RASGRF2; MAP3K11
Ras signaling pathway
GNB4; PDGFB; GNG11; GNG7; IGF1R; KLK1B4; FGF19; FGF11; GNG4; MLLT4
Rap signaling pathway
P2RY1; RRAS; VEGFC; FGF3; RAF1; INS1; ACTB; AKT2; FGF20; ITGB2
cAMP signaling pathway
GRIN2A; SLC9A1; RRAS2; GLI3; GRIN3B; ATP1B3; PIK3R2; ATP2B1; CALM3; HCN2
Chemokine signaling pathway
GNG8; Ccl9; ADRBK1; CCL23; CCL25; CCR5; CCL2; GNB1; CCL16; IKBKG
Sphingolipid signaling pathway
SPTLC1; PPP2R5A; MAPK11; MAPK13; SGPL1; PLCB4; PTEN; PIK3CG; PPP2R2B; GAB2
Wnt signaling pathway
WNT8B; LRP5; CUL1B; TCF7; PRKACG; WNT2B; CCND2A; FBXW11B; FZD8; FRAT2
Axon guidance
DPYSL5; ACTR2B; GFRA1; MYL12A; SEMA3E; EFNB3; GSK3B; EFNA1A; CSNK2A2; RND1L
VEGF signaling pathway
SHC2; MAPK14B; MAP2K2B; CASP9; PPP3CCB; PXN; MAPK1; HRASB; SRC; RAC3B
Focal adhesion
GRB2A; ACTB2; SPP1; BCL2; LAMA5; CCND1; AKT1; VCL; ITGA9; TNC
Adherens junction
TJP1; SMAD2; ACTN1; CSNK2A2A; TGFBR1B; TGFBR1; WASF2; SMAD4; SRC; WASF1
Natural killer cell mediated cytotoxicity
ZAP70; PTK2B; SAMD3; IFNAR1; TNFRSF10B; TNFRSF10D; PIK3R2; PIK3CD; PLCG1; PTPN11
B cell receptor signaling pathway
CDK6; PLCG2; RAC2; PRKCB; CDK7; CDK4; SLA2; BLK; DUSP6; CD19
Fc epsilon RI signaling pathway
MAP2K6; PLA2G4B; PIK3CB; MAPK10; PIK3R1; PLA2G4F; KRAS; MAP2K2; MAPK3; PLA2G4A
Fc gamma R-mediated phagocytosis
WASF3; WASL; INPP5D; ASAP2; HCK; CFL1; ASAP3; cgr2b; PIK3R1; PLCG2
Leukocyte transendothelial migration
BCAR1; ACTB; CLDN17; MYL12B; MMP9; NCF1; CLDN1; CLDN16; CLDN11; ACTN4
Regulation of actin cytoskeleton
PAK6; GNA13A; Pdgfa&Pdgfb; MYLPFA; PIK3R1; MYLPFB; MYL9B; SOS1; FGF19; FGF17
Pathways in cancer
TGFBR2; FH1; LAMA4; AKT1; FGFR3; HGF; KIT; PTGER1; MAPK1; TRAF1
Colorectal cancer
FOS; PIK3CD; MSH3; GSK3B; CASP9; CCND1; AKT1; TGFB1; APC2; PIK3R1
Pancreatic cancer
TGFA; KRAS; RB1; BCL2L1; PIK3CB; TGFB3; IKBKB; MAP2K1; STAT3; CASP9
Choline metabolism in cancer
SLC5A7; DGKG; PLD2; RAF1; PPAP2C; Pdgfa&Pdgfb; PPAP2A; PIK3CD; PDGFD; PRKCB
Viral myocarditis
ABL2; HLA-F; SGCG; HLA-DRB5; HLA-DRB1; HLA-E; RAC3; RAC2; SGCA; MYH7

Protein Function

RAC2 has several biochemical functions, for example, GTP binding, GTPase activity, protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAC2 itself. We selected most functions RAC2 had, and list some proteins which have the same functions with RAC2. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein MTG1; SAR1B; SEPT10; TUBA1A; GNL1; RAB6B; RHEBL1; GSPT2; RAP2AB; EIF5
Function GTPase activity
Related Protein IFT27; RAB40AL; IFT22; RAB2A; RAB27A; ARF5; RRAGCB; RHEB; RABL2A; MX1
Function protein kinase regulator activity
Related Protein RAC2; FAF1; KIDINS220B; CDC37; CDK5RAP1; KIDINS220; APC; ANKRD54; CSNK2B

Interacting Protein

RAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAC2.
ARHGDIB; XIAP; NCF2; WAS; PAK1; CHGB; pnp; ilvD; ADAM22; AFG3L2; VCAM1

RAC2 Related Articles

Shelef, MA; Tauzin, S; et al. Neutrophil migration: moving from zebrafish models to human autoimmunity. IMMUNOLOGICAL REVIEWS 256:269-281(2013).
Cai, CQ; Tang, SH; et al. Requirement for both receptor-operated and store-operated calcium entry in N-formyl-methionine-leucine-phenylalanine-induced neutrophil polarization. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430:816-821(2013).