RAC2
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Official Full Name
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
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Overview
The Rho family of GTPases or small G-proteins, most Rho, and Cdc42, are all implicated in different aspects of regulation of cytoskeletal signaling when in their GTP-bound active state. Rac, Rho and Cdc42 encompass the assembly of actin-based structures such as lamellipodia, stress fibers, and filopodia, respectively. Together they help control the organization of the actin cytoskeleton, proliferation, apoptosis, membrane transport and gene expression. Rac, Cdc42, and Rho work in concert with one a involved in lamellipodia formation,Works with Cdc42,Involved in cell polarization and filopodia formation, through their downstream targets WAVE and WASP, respectively, that signal through the Arp2/3 complex to the actin cytoskeleton. This signaling enables the coordination of cell migration at the leading edge by inducing the migrating cell to stimulate actin-mediated membrane protrusion. The downstream target of Rac,WAVE-1, functions as a scaffolding protein that directs actin reorganization by relaying signals from Rac to the Arp2/3 complex. The continued addition of actin monomers in this branched network is thought to provide the driving force for the extension of the membrane that occurs during lamellipodial protrusion. -
Synonyms
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); ras-related C3 botulinum toxin substrate 2; EN 7; p21-Rac2; small G protein; rho family, small GTP binding protein Rac2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Gx; EN-7; HSPC022;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Human
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- RAC2 Related Articles
- RAC2 Related Research Area
- RAC2 Related Signal Pathway
RAC2 involved in several pathways and played different roles in them. We selected most pathways RAC2 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | ZAK;NTRK2B;CACNB4A;FGF11A;MAP4K3;NF1;ARRB1;FASLG;MAPK13 |
Ras signaling pathway | VEGFB;RASAL1;PLA2G10;RASA1;GNG4;ANGPT1;INSR;MLLT4;GNG2 |
Rap signaling pathway | GNAI3;GNAO1;PRKCI;PDGFRB;CDC42;FGFR3;SRC;GNAQ;FGF14 |
cAMP signaling pathway | BAD;PIK3R5;ACOX3;CAMK4;Adcy4;CNGA1;NPY1R;GPR119;GRIN2B |
Chemokine signaling pathway | XCR1;CCL4;GNG12;PLCB2;IL-8;GNAI2;CXCL14;IKBKB;CCL26 |
Sphingolipid signaling pathway | PRKCB;FYN;PLD1;GNA12;PIK3R3;LASS2;MAPK3;PDPK1;OPRD1 |
Wnt signaling pathway | WNT9B;PRKACBB;TBL1X;BAMBI;LRP6;DKK4;RAC3A;NFATC4;FOSL1A |
Axon guidance | TRIO;COL6A1;CNTN1;PAK3;ACTR2B;RASGEF1A;ST8SIA2;CNTN6;DPYSL2 |
VEGF signaling pathway | MAPK12B;PPP3CB;PIK3R1;RAF1B;PIK3R3;MAPKAPK3;RAC1B;PIK3CA;RAC1 |
Focal adhesion | PAK7;ITGB7;MYL12A;MAPK10;FLNB;ITGB1;PARVG;PDGFRA;VAV2 |
Adherens junction | LMO7;CSNK2A2A;RAC1B;ACTB;WASF3B;CTNNA1;ACTB1;MAP3K7;RHOAD |
Natural killer cell mediated cytotoxicity | FASLG;FCGR3B;ZAP70;RAET1L;TNF;ICAM2;GZMB;PIK3R5;PAK1 |
B cell receptor signaling pathway | CD81;LCP2A;HDAC5;HRAS;VAV3;FOS;RAP2A;SLA2;NFATC2 |
Fc epsilon RI signaling pathway | PIK3CG;SOS1;RAC2;RAF1;NRAS;MAPK10;RAC1;LAT;AKT1 |
Fc gamma R-mediated phagocytosis | PLCG2;BIN1;PLD1;PTPRC;GSN;MAPK3;LAT;FCGR2A;FCGR1A |
Leukocyte transendothelial migration | RHOA;ROCK1;CYBB;VCAM1;PXN;PIK3CG;MAPK11;MMP2;MLLT4 |
Regulation of actin cytoskeleton | FGFR2;WASB;MAPK6;PIP4K2AA;SSH3;VAV1;KRAS;ARHGEF7A;Fgf15 |
Pathways in cancer | MAPK3;PTGS2;GNA11;GNGT1;MAP2K1;GNG7;VEGFB;TRAF3;SMAD3 |
Colorectal cancer | PIK3R3;FOS;MAPK9;MAPK10;GSK3B;TGFB3;PIK3CB;LEF1;PIK3CD |
Pancreatic cancer | TGFBR1;SMAD4;IKBKB;PLD1;RAD51;KRAS;STAT3;PIK3CG;ARHGEF6 |
Choline metabolism in cancer | DGKB;TAE1;MAPK9;PIK3CD;PIK3R2;RPS6KB2;EIF4EBP1;DGKA;PLA2G4D |
Viral myocarditis | SGCD;HLA-B;HLA-F;HLA-DQA2;CD40;CCND1;MYH7;H2-AB1;EIF4G2 |
RAC2 has several biochemical functions, for example, GTP binding, GTPase activity, protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAC2 itself. We selected most functions RAC2 had, and list some proteins which have the same functions with RAC2. You can find most of the proteins on our site.
Function | Related Protein |
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GTP binding | ARL4C;RAP1AA;GNAI2A;RAP1AB;SEPT7A;RHOA;RHOGD;RAB44;MXC |
GTPase activity | IRGE4;GNL2;EIF5B;RAB22A;GNA11B;NKIRAS2;RAB3DB;RALAB;RAB39B |
protein kinase regulator activity | KIDINS220;ANKRD54;RAC2;CDK5RAP1;CSNK2B;CDC37;KIDINS220B;FAF1;APC |
RAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAC2.
ARHGDIB; XIAP; NCF2; WAS; PAK1; CHGB; pnp; ilvD; ADAM22; AFG3L2; VCAM1
- Q&As
- Reviews
Q&As (5)
Ask a questionSeveral small molecule inhibitors targeting RAC2 are under development for the treatment of cancer and other diseases.
Like any targeted therapy, RAC2 inhibitors may have potential side effects, which need to be carefully evaluated in clinical trials.
RAC2 interacts with various downstream effectors and signaling molecules to regulate cellular processes such as cytoskeletal dynamics and gene expression.
Yes, mutations in the RAC2 gene have been linked to primary immunodeficiency disorders, affecting the function of immune cells.
Yes, abnormal expression or activity of RAC2 has been observed in certain diseases, making it a potential biomarker for diagnostic purposes.
Customer Reviews (3)
Write a reviewRAC2 protein has shown great utility in protein electron microscopy structure analysis.
The use of RAC2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.
By visualizing the structural features, interactions, and conformational changes of RAC2, researchers gain valuable insights into its function and potential for therapeutic interventions.
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