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RHOC

  • Official Full Name

    ras homolog family member C

  • Overview

    This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    RHOC; ras homolog family member C; H9; ARH9; ARHC; RHOH9; rho-related GTP-binding protein RhoC; rhoC GTPase; oncogene RHO H9; rho cDNA clone 9; RAS-related homolog 9; small GTP binding protein RhoC; ras homolog gene family, member C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RHOC-2732H Active Recombinant Human RHOC protein, His-tagged E.coli His
Human RHOC-1628H Recombinant Human Ras Homolog Gene Family, Member C, His-tagged E.coli His
Human RHOC-30285TH Recombinant Human RHOC, His-tagged E.coli His 190 amino acids
Human RHOC-30286TH Recombinant Human RHOC E.coli N/A
Human RHOC-2768H Recombinant Human Ras Homolog Gene Family, Member C, His-tagged E.coli His
Human RHOC-2351HCL Recombinant Human RHOC 293 Cell Lysate HEK293 N/A
Human RHOC-2352HCL Recombinant Human RHOC 293 Cell Lysate HEK293 N/A
Human RHOC-572H Recombinant Human RHOC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RHOC-1889H-B Recombinant Human RHOC Protein Pre-coupled Magnetic Beads HEK293
Human RHOC-301274H Recombinant Human RHOC protein, GST-tagged E.coli GST Met1-Leu193
Human RHOC-1350HFL Recombinant Full Length Human RHOC Protein, C-Flag-tagged Mammalian cells Flag
Human RHOC-1889H Recombinant Human RHOC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RHOC-14172M Recombinant Mouse RHOC Protein Mammalian Cell His
Mouse RHOC-7588M-B Recombinant Mouse RHOC Protein Pre-coupled Magnetic Beads HEK293
Mouse Rhoc-643M Recombinant Mouse Rhoc Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse RHOC-7588M Recombinant Mouse RHOC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken RHOC-2215C Recombinant Chicken RHOC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RHOC Related Articles
  • RHOC Related Research Area

RHOC involved in several pathways and played different roles in them. We selected most pathways RHOC participated on our site, such as Axon guidance, Developmental Biology, G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceRASGRP1;ITGB1;DPYSL2B;PAK4;RAC3;DPYSL2;ROBO3;KIF4A;SCN4A
Developmental BiologyGPC1A;SCN3A;LGI2;BOC;COL6A2;SPTB;AP2A1;TRPC3;MED6
G alpha (12/13) signalling eventsKALRNB;GNA13B;KALRN;FGD4;DCLRE1B;OBSCN;ARHGEF1B;RHOB;RHOGA
GPCR downstream signalingMLN;RGR;RLN3;ADM;FGD4;OR2AP1;PNOC;ARHGEF25;FGD2
RHO GTPase EffectorsWIPF2;RHOAE;PMF1;CCDC99;KNTC1;FMNL1;SKA1;NOXO1A;NSL1
RHO GTPases Activate ForminsZWILCH;CLIP1;NDEL1B;FMNL2;RCC2;SKA1;SGOL2;MKL1B;RHOAE
RHO GTPases Activate ROCKsRHOAE;RHOC
RHO GTPases Activate Rhotekin and RhophilinsRHPN1;TAX1BP3;RTKN;ROPN1;LIN7B;RHOC;RHPN2

RHOC has several biochemical functions, for example, GTP binding, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOC itself. We selected most functions RHOC had, and list some proteins which have the same functions with RHOC. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRND1;NKIRAS1;GTPBP8;RAB43;MXC;GNA12;DIRAS1;RRAS2;DRG2
protein bindingTRIM3;MAPK14;ASB7;PYY;GFM1;GNAS;C1QA;RABIF;MED9
signal transducer activityOLFR11;LPAR6;CREBBP;OLFR24;TACR1B;MAPKAPK2;TAAR8B;OLFR481;S100A9

RHOC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOC here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOC.

FAM65B; env; Diaph1; DIAPH1; sseJ; DAAM1; GH1; MCC; VHL; ARHGDIA; IKBKE; CNKSR1; PINX1; TRAF6; ARHGAP1

Zhao, ZH; Tian, Y; et al. RhoC, vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma. WORLD JOURNAL OF GASTROENTEROLOGY 21:905-912(2015).
Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).
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