rhoc
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  • Official Full Name
  • ras homolog family member C
  • Background
  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RHOC; ras homolog family member C; H9; ARH9; ARHC; RHOH9; rho-related GTP-binding protein RhoC; rhoC GTPase; oncogene RHO H9; rho cDNA clone 9; RAS-related homolog 9; small GTP binding protein RhoC; ras homolog gene family, member C;
Cat.#:RHOC-1628HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member C, His-tagged
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Cat.#:RHOC-2732HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOC protein, His-tagged
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Cat.#:RHOC-2768HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member C, His-tagged
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Cat.#:RHOC-30285THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOC, His-tagged
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Cat.#:RHOC-30286THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOC
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Cat.#:RHOC-14172MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RHOC Protein
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Cat.#:RHOC-2215CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RHOC
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Cat.#:RHOC-2351HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RHOC 293 Cell Lysate
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Cat.#:RHOC-2352HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RHOC 293 Cell Lysate
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Involved Pathway

RHOC involved in several pathways and played different roles in them. We selected most pathways RHOC participated on our site, such as Axon guidance, Developmental Biology, G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
ADAM10; ARPC1A; SEMA5B; COL9A1B; SEMA3AB; PAQR3A; ITGB1B.1; SPTB; AP2A2; SPNA1
Developmental Biology
DNM2; COL6A1; MED15; PITPNA; DPYSL2; EPHB4A; MED21; KDR; COL9A3; CDK5R1B
G alpha (12/13) signalling events
ARHGEF9; KALRNB; MCF2L; RHOB; KALRN; GNA13B; ARHGEF17; ARHGAP4; ARHGEF18; ARHGAP4A
GPCR downstream signaling
ABR; RHOAE; FPR-RS6; KALRN; UTS2; GCGA; CXCL13; CCL35.2; PTH; RASGRP2
RHO GTPase Effectors
DSN1; FMNL2; RANGAP1B; MIS12; PMF1; MKL1B; NDEL1A; CCDC99; TAX1BP3; NDEL1B
RHO GTPases Activate Formins
SKA2; NSL1; DIAPH1; MKL1; RCC2; SPDL1; NUF2; ZWILCH; MKL1B; KNTC1
RHO GTPases Activate ROCKs
RHOC; RHOAE
RHO GTPases Activate Rhotekin and Rhophilins
ROPN1; TAX1BP3; RTKN; LIN7B; RHPN1; RHOC; RHPN2

Protein Function

RHOC has several biochemical functions, for example, GTP binding, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOC itself. We selected most functions RHOC had, and list some proteins which have the same functions with RHOC. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein GBP6; SEPT10; RALBB; RAP2A; RSG1; EEF2A.1; RAB39BA; NUDT16; GIMAP7; TUBA3D
Function protein binding
Related Protein PCTP; GTPBP10; DCAF8; SNX32; VEGFAB; BLOC1S5; OSBP; FAM54B; TINF2; MIA3
Function signal transducer activity
Related Protein PLEKHG5; GNRHR3; GNG10; MTNR1C; GAB1; OLFR469; TAAR10A; OPN4XB; PPP5C; PTGER1A

Interacting Protein

RHOC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOC here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOC.
FAM65B; env; Diaph1; DIAPH1; sseJ; DAAM1; GH1; MCC; VHL; ARHGDIA; IKBKE; CNKSR1; PINX1; TRAF6; ARHGAP1

RHOC Related Articles

Zhao, ZH; Tian, Y; et al. RhoC, vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma. WORLD JOURNAL OF GASTROENTEROLOGY 21:905-912(2015).
Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).