RNF4
-
Official Full Name
ring finger protein 4 -
Synonyms
RNF4;ring finger protein 4;SLX5;SNURF;RES4-26;E3 ubiquitin-protein ligase RNF4;E3 ubiquitin ligase RNF4;small nuclear RING finger protein;EC=6.3.2;Protein SNURF;002938
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- GST
- Avi
- Fc
Involved Pathway
RNF4 involved in several pathways and played different roles in them. We selected most pathways RNF4 participated on our site, such as Adaptive Immune System,Androgen receptor signaling pathway,Antigen processing: Ubiquitination &, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome degradation | UBE2F,LRR1,SH3RF1,TRIM39,TPP2,PJA1,BLMH,UBE2V1,TRIM41,TRAF7 |
| Homology Directed Repair | RTEL1,RHNO1,PPP4R2,EME2,GEN1,TOPBP1,RAD51AP1,FUZ,TIPIN,PPP4R2B |
| DNA Double-Strand Break Repair | PPP4R2A,EYA3,TDP1,KDM4B,GEN1,RAD51AP1,PARP2,RAD50,TIMELESS,CHEK1 |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | BRCC3,HUS1,RAD1,PPP4CA,TIPIN,KIAA0146,EME2,RAD9B,RNF168,EME1 |
| Class I MHC mediated antigen processing & | CTSL1,RNF144B,TRIM9,RNF41,CD207,UBE2E3,TRAF7,RNF220,HECTD3,UBE2V1 |
| presentation | CD207,TRIM39,WSB1,ASB13,RNF144B,SPSB4,UBE2V1,B2ML,RNF6,CYBA |
| Androgen receptor signaling pathway | AES,RNF6,KAT5,SVILA,STUB1,RAD54L2,TGFB1I1,MYST2,DAXX,KAT7B |
| DNA Repair | PPP4CA,SPRTN,ALKBH3,TIPIN,UBE2V2,YY1,DCLRE1A,USP10,USP45,CHEK2 |
| Adaptive Immune System | ATG7,AKT3,SEC23A,MAPKAP1,ASB11,RNF14,DTX3L,KIF20A,ERAP1,SEC24A |
Protein Function
RNF4 has several biochemical functions, for example, DNA binding,SUMO polymer binding,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF4 itself. We selected most functions RNF4 had, and list some proteins which have the same functions with RNF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | G2E3,MARCH1,BIRC5A,LRSAM1,FBXO3,HERC2,CNOT4,TRIM68,RCHY1,MARCH6 |
| zinc ion binding | MAP3K7IP3,LIMK2,ACE,RFWD2,CPA5,NR1D4B,TLL1,FTR14,UBR5,RARAB |
| SUMO polymer binding | SIMC1,RNF222,RNF111,SOBP |
| androgen receptor binding | CCNE1,TRIM68,PRMT2,NRIP1,Ar,GRIP1,KDM3A,PKN1,RAN,SMARCA4 |
| identical protein binding | WRNIP1,MPST,TNF,MRI1,RIPK1,EID3,PAFAH1B3,AGXT2,PACSIN2,STK4 |
| protein binding | KCNA3,COMMD8,POLD1,FLOT2,PIF1,JAGN1,GIPC1,EMP2,PABPC1,CRYBB3 |
| nucleosome binding | RNF169,ZNHIT1,SMARCA5,HP1BP3,L3MBTL1,NOC2L,MUM1,RNF168,ARID1A,DNTTIP1 |
| ubiquitin protein ligase activity | CMTM2A,UBE3C,RNF217,ZNRF2,MED17,RNF222,CBL,RAG2,UBE2W,TOPORS |
| transcription coactivator activity | MNT,ARNT,NRIP1,CD3D,HCFC2,UBE2L3,MED20,PIAS1,USP16,RBPMS |
Interacting Protein
RNF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF4.
UBE2I;TRPS1;PARP1;UBA1;UBE2N;SRPK2;UBE2V1;NFATC2IP;HIP2;SKIL;UBE2D1;UBE2E1;UBE2D3;UBE2H;UBE2D2;cdsA
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References
- Hendriks, IA; Treffers, LW; et al. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. CELL REPORTS 10:1778-1791(2015).
- Pagadala, NS; Perez-Pineiro, R; et al. In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 91:118-131(2015).
