Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

ROBO1

  • Official Full Name

    roundabout, axon guidance receptor, homolog 1 (Drosophila)

  • Overview

    Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms

    ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila); SAX3; DUTT1; roundabout homolog 1; deleted in U twenty twenty;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Fc
  • hFc
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ROBO1-30953TH Recombinant Human ROBO1 Wheat Germ N/A 99 amino acids
Human ROBO1-594H Recombinant Human ROBO1 Mammalian Cell His
Human ROBO1-2256HCL Recombinant Human ROBO1 293 Cell Lysate HEK293 N/A
Human ROBO1-4672H Recombinant Human ROBO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ROBO1-1893H Active Recombinant Human ROBO1 protein, His-tagged HEK293 His GIn 26 - Pro 897
Human ROBO1-136H-B Recombinant Human ROBO1 Protein Pre-coupled Magnetic Beads HEK293
Human ROBO1-001H Active Recombinant Human ROBO1 Protein, Fc-tagged Mammalian cells Fc
Human ROBO1-0661H Active Recombinant Human ROBO1 protein, His-tagged, FITC-Labeled HEK293 His GIn26-Pro897
Human ROBO1-041H Recombinant Human ROBO1 protein, hFc-tagged(VLPs) HEK293 hFc Met1-Pro897
Human ROBO1-042H Active Recombinant Human ROBO1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi GIn 26 - Pro 897
Human ROBO1-136H Recombinant Human ROBO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Robo1-5566M Recombinant Mouse Robo1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ROBO1-2415M Recombinant Mouse ROBO1 Protein (880-1612 aa), His-tagged Yeast His 880-1612 aa
Mouse Robo1-5059M Recombinant Mouse Robo1 protein, His-tagged HEK293 His 880-1612aa
Rat Robo1-988R Active Recombinant Rat Robo1 Protein, Fc Chimera Mammalian cells Fc
Rat ROBO1-5092R Recombinant Rat ROBO1 Protein Mammalian Cell His
Rat Robo1-17R Recombinant Rat Robo1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Robo1-17R-B Recombinant Rat Robo1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ROBO1-9040Z Recombinant Zebrafish ROBO1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ROBO1 Related Articles
  • ROBO1 Related Research Area

ROBO1 involved in several pathways and played different roles in them. We selected most pathways ROBO1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROBO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceEFNA2A;DPYSL4;LRRC4C;RNF8;MAPK1;SIAH2;SEMA3AA;DUSP6;LIMK1

ROBO1 has several biochemical functions, for example, LRR domain binding, axon guidance receptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROBO1 itself. We selected most functions ROBO1 had, and list some proteins which have the same functions with ROBO1. You can find most of the proteins on our site.

Function Related Protein
LRR domain bindingZXDC;KRAS;POLR2J;ROBO1;STK11;LRRFIP2
axon guidance receptor activityROBO2;EPHB1;EPHB3;ROBO1;EPHA7;SEMA5A;GFRA3
identical protein bindingAHI1;CEP170L;UHRF1;RUVBL2;DIAP1;CALHM1;S100A2;EPHA4;PSME3
protein bindingATP5G1;PFN2;ANKRD17;CERK;TRPS1;POLD2;HERPUD1;EPM2A;SMN1

ROBO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROBO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROBO1.

ROBO4; ROBO2; TUBB4A; BRK1

Nakayama, T; Mizohata, E; et al. Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses. PROTEIN SCIENCE 24:328-340(2015).
Qi, CL; Lan, HM; et al. Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis. LABORATORY INVESTIGATION 94:766-776(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the association between ROBO1 recombinant protein and tumors? 10/23/2022

Some studies have shown that ROBO1 recombinant protein may be involved in the initiation and progression of tumors, especially in neurological tumors.

Does ROBO1 recombinant protein function in pregnant women? 04/01/2022

The level of ROBO1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.

Does ROBO1 have a function in the human body? 09/21/2021

ROBO1 is mainly involved in axon guidance and neural network formation in the human body, affecting the development and function of the nervous system.

If the level of ROBO1 recombinant protein is abnormal, what should I do? 05/20/2021

If the level of ROBO1 recombinant protein is abnormal, treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

Is there a treatment for ROBO1 recombinant proteins? 08/15/2020

The current treatments for ROBO1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for axon guidance.

What is the association between ROBO1 recombinant protein and neurological diseases? 03/13/2020

ROBO1 recombinant protein may be involved in the occurrence and progression of neurological diseases, especially in glioma, neural tube defects, and autism.

Customer Reviews (3)

Write a review
Reviews
06/28/2023

    ROBO1 is able to maintain its biological activity and structural integrity under specific experimental conditions.

    06/07/2022

      ROBO1 products have low endotoxin levels and do not interfere with experimental results.

      07/31/2021

        When using ROBO1 for experiments, you can get a clear and reliable interpretation of your results.

        Ask a Question for All ROBO1 Products

        Required fields are marked with *

        My Review for All ROBO1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends