ROBO1

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ROBO1

Official Full Name roundabout, axon guidance receptor, homolog 1 (Drosophila)
Background Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Synonyms ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila); SAX3; DUTT1; roundabout homolog 1; deleted in U twenty twenty;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ROBO1-001H Recombinant Human ROBO1 Protein, Fc-tagged NS0 Fc
    Mouse ROBO1-2415M Recombinant Mouse ROBO1 Protein (880-1612 aa), His-tagged Yeast His
    Human ROBO1-4672H Recombinant Human ROBO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Robo1-5566M Recombinant Mouse Robo1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human ROBO1-2256HCL Recombinant Human ROBO1 293 Cell Lysate HEK293 N/A
    Human ROBO1-30953TH Recombinant Human ROBO1 Wheat Germ N/A
    Human ROBO1-594H Recombinant Human ROBO1 Mammalian Cell His
    Rat ROBO1-5092R Recombinant Rat ROBO1 Protein Mammalian Cell His
    Rat Robo1-988R Recombinant Rat Robo1 Protein, Fc Chimera NS0 Fc
    Zebrafish ROBO1-9040Z Recombinant Zebrafish ROBO1 Mammalian Cell His

    ROBO1 involved in several pathways and played different roles in them. We selected most pathways ROBO1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROBO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance FGF20A; PAQR3B; SCN3A; SRGAP2; DNM1; ADAM10; RASGRP1; LAMTOR2; GPC1B; SPTBN2

    ROBO1 has several biochemical functions, for example, LRR domain binding, axon guidance receptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROBO1 itself. We selected most functions ROBO1 had, and list some proteins which have the same functions with ROBO1. You can find most of the proteins on our site.

    Function Related Protein
    LRR domain binding LRRFIP2; KRAS; ROBO1; POLR2J; STK11; ZXDC
    axon guidance receptor activity ROBO1; SEMA5A; EPHA7; EPHB1; ROBO2; GFRA3; EPHB3
    identical protein binding CLDN2; PON2; ADIPOQ; DYNLT1C; PTPRM; SNX33; THG1L; SH3GL3; ITGB3; PARK2
    protein binding NLRP3; TCF7L2; PEX14; TSPAN4; PYGM; NOXA1; EGLN2; TEKT4; UCKL1; IPO11

    ROBO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROBO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROBO1.

    ROBO4; ROBO2; TUBB4A; BRK1

    Nakayama, T; Mizohata, E; et al. Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses. PROTEIN SCIENCE 24:328-340(2015).
    Qi, CL; Lan, HM; et al. Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis. LABORATORY INVESTIGATION 94:766-776(2014).

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