|Official Full Name||roundabout, axon guidance receptor, homolog 1 (Drosophila)|
|Background||Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]|
|Synonyms||ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila); SAX3; DUTT1; roundabout homolog 1; deleted in U twenty twenty;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ROBO1 involved in several pathways and played different roles in them. We selected most pathways ROBO1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROBO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Axon guidance||FGF20A; PAQR3B; SCN3A; SRGAP2; DNM1; ADAM10; RASGRP1; LAMTOR2; GPC1B; SPTBN2|
ROBO1 has several biochemical functions, for example, LRR domain binding, axon guidance receptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROBO1 itself. We selected most functions ROBO1 had, and list some proteins which have the same functions with ROBO1. You can find most of the proteins on our site.
|LRR domain binding||LRRFIP2; KRAS; ROBO1; POLR2J; STK11; ZXDC|
|axon guidance receptor activity||ROBO1; SEMA5A; EPHA7; EPHB1; ROBO2; GFRA3; EPHB3|
|identical protein binding||CLDN2; PON2; ADIPOQ; DYNLT1C; PTPRM; SNX33; THG1L; SH3GL3; ITGB3; PARK2|
|protein binding||NLRP3; TCF7L2; PEX14; TSPAN4; PYGM; NOXA1; EGLN2; TEKT4; UCKL1; IPO11|
ROBO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROBO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROBO1.
ROBO4; ROBO2; TUBB4A; BRK1