| Description : |
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
175.7 kDa |
| AA Sequence : |
MIAEPAHFYLFGLICLCSGSRLRQE DFPPRIVEHPSDLIVSKGEPATLNC KAEGRPTPTIEWYKGGERVETDKDD PRSHRMLLPSGSLFFLRIVHGRKSR PDEGVYVCVARNYLGEAVSHNASLE VAILRDDFRQNPSDVMVAVGEPAVM ECQPPRGHPEPTISWKKDGSPLDDK DERITIRGGKLMITYTRKSDAGKYV CVGTNMVGERESEVAELTVLERPSF VKRPSNLAVTVDDSAEFKCEARGDP VPTVRWRKDDGELPKSRYEIRDDHT LKIRKVTAGDMGSYTCVAENMVGKA EASATLTVQVGSEPPHFVVKPRDQV VALGRTVTFQCEATGNPQPAIFWRR EGSQNLLFSYQPPQSSSRFSVSQTG DLTITNVQRSDVGYYICQTLNVAGS IITKAYLEVTDVIADRPPPVIRQGP VNQTVAVDGTFVLSCVATGSPVPTI LWRKDGVLVSTQDSRIKQLENGVLQ IRYAKLGDTGRYTCIASTPSGEATW SAYIEVQEFGVPVQPPRPTDPNLIP SAPSKPEVTDVSRNTVTLSWQPNLN SGATPTSYIIEAFSHASGSSWQTVA ENVKTETSAIKGLKPNAIYLFLVRA ANAYGISDPSQISDPVKTQDVLPTS QGVDHKQVQRELGNAVLHLHNPTVL SSSSIEVHWTVDQQSQYIQGYKILY RPSGANHGESDWLVFEVRTPAKNSV VIPDLRKGVNYEIKARPFFNEFQGA DSEIKFAKTLEEAPSAPPQGVTVSK NDGNGTAILVSWQPPPEDTQNGMVQ EYKVWCLGNETRYHINKTVDGSTFS VVIPFLVPGIRYSVEVAASTGAGSG VKSEPQFIQLDAHGNPVSPEDQVSL AQQISDVVKQPAFIAGIGAACWIIL MVFSIWLYRHRKKRNGLTSTYAGIR KVTYQRGGEAVSSGGRPGLLNISEP AAQPWLADTWPNTGNNHNDCSISCC TAGNGNSDSNLTTYSRPADCIANYN NQLDNKQTNLMLPESTVYGDVDLSN KINEMKTFNSPNLKDGRFVNPSGQP TPYATTQLIQSNLSNNMNNGSGDSG EKHWKPLGQQKQEVAPVQYNIVEQN KLNKDYRANDTVPPTIPYNQSYDQN TGGSYNSSDRGSSTSGSQGHKKGAR TPKVPKQGGMNWADLLPPPPAHPPP HSNSEEYNISVDESYDQEMPCPVPP ARMYLQQDELEEEEDERGPTPPVRG AASSPAAVSYSHQSTATLTPSPQEE LQPMLQDCPEETGHMQHQPDRRRQP VSPPPPPRPISPPHTYGYISGPLVS DMDTDAPEEEEDEADMEVAKMQTRR LLLRGLEQTPASSVGDLESSVTGSM INGWGSASEEDNISSGRSSVSSSDG SFFTDADFAQAVAAAAEYAGLKVAR RQMQDAAGRRHFHASQCPRPTSPVS TDSNMSAAVMQKTRPAKKLKHQPGH LRRETYTDDLPPPPVPPPAIKSPTA QSKTQLEVRPVVVPKLPSMDARTDR SSDRKGSSYKGREVLDGRQVVDMRT NPGDPREAQEQQNDGKGRGNKAAKR DLPPAKTHLIQEDILPYCRPTFPTS NNPRDPSSSSSMSSRGSGSRQREQA NVGRRNIAEMQVLGGYERGEDNNEE LEETESTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
