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RPA2

  • Official Full Name

    replication protein A2, 32kDa

  • Overview

    Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
  • Synonyms

    RPA2; replication protein A2, 32kDa; replication protein A2 (32kD); replication protein A 32 kDa subunit; RP-A p32; RP-A p34; RF-A protein 2; replication factor A protein 2; replication protein A 34 kDa subunit; REPA2; RPA32;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPA2-2852H Recombinant Human Replication Protein A2, 32kDa, His-tagged E.coli His
Human RPA2-31146TH Recombinant Human RPA2, His-tagged E.coli His 270 amino acids
Human RPA2-30437TH Recombinant Human RPA2, T7 -tagged E.coli T7
Human RPA2-2983H Recombinant Human RPA2, T7-tagged E.coli T7
Human RPA2-176H Recombinant Human RPA2 protein, T7-tagged E.coli T7
Human RPA2-2242HCL Recombinant Human RPA2 293 Cell Lysate HEK293 N/A
Human RPA2-3103H Recombinant Human RPA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RPA2-3440H Recombinant Human RPA2 protein, GST-tagged E.coli GST 1-267aa
Human RPA2-1430HFL Recombinant Full Length Human RPA2 Protein, C-Flag-tagged Mammalian cells Flag
Human RPA2-3892H Recombinant Human RPA2 protein, His-tagged E.coli His 80-270 aa
Human RPA2-1910H Recombinant Human RPA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RPA2-1910H-B Recombinant Human RPA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rpa2-5579M Recombinant Mouse Rpa2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat RPA2-5099R Recombinant Rat RPA2 Protein Mammalian Cell His
Rat RPA2-4758R-B Recombinant Rat RPA2 Protein Pre-coupled Magnetic Beads HEK293
Rat RPA2-4758R Recombinant Rat RPA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RPA2-3959R Recombinant Rhesus monkey RPA2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RPA2-3776R Recombinant Rhesus Macaque RPA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RPA2-3776R-B Recombinant Rhesus Macaque RPA2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RPA2-9233Z Recombinant Zebrafish RPA2 Mammalian Cell His
Chicken RPA2-2581C Recombinant Chicken RPA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RPA2 Related Articles

RPA2 involved in several pathways and played different roles in them. We selected most pathways RPA2 participated on our site, such as DNA replication, Nucleotide excision repair, Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA replicationDBF4;RPA1;CDT1;MCM5;LIG1;FEN1;POLD2;POLD4;GINS1
Nucleotide excision repairCUL4B;ERCC1;COPS3;COPS2;COPS6;ERCC3;COPS4;XPC;GTF2H2C
Mismatch repairMSH6;MLH1;EXO1;PCNA;POLD4;POLD2;SSBP1;MSH3;RFC3
Homologous recombinationTOP3A;RAD51D;POLD4;RAD51;RPA1;BRCA2;RPA2;RAD51L1;CDK5R2
Fanconi anemia pathwayRMI2;FANCF;HES1;SLX1B;TOP3A;FUZ;REV1;EME1;RPA1

RPA2 has several biochemical functions, for example, damaged DNA binding, enzyme binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPA2 itself. We selected most functions RPA2 had, and list some proteins which have the same functions with RPA2. You can find most of the proteins on our site.

Function Related Protein
damaged DNA bindingRAD23AB;XPC;RAD1;TRP63;NEIL3;RPA2;EP300;FANCG;RAD23AA
enzyme bindingHINFP;CASP2;SUDS3;HIST1H2AK;TMBIM6;DIS3L;ACAT1;KIAA1967;CDC20
protein N-terminus bindingALG2;RND2;STX5;BIRC2;ATM;HDAC1;YWHAQ;VPS25;SMARCE1
protein bindingDUSP23;TCF7L2;RELL2;FKBP1B;ZMAT3;FLNA;LILRB4;C19orf47;COMMD8
protein phosphatase bindingKAT2A;STAT3;ANAPC7;PARD3;VCAN;JUPA;MET;PPP1R3C;GNB2L1
single-stranded DNA bindingSSBP3;NCL;TDP1;CRY2;SUB1;XRCC3;BRCA2;MCM10;PURB
ubiquitin protein ligase bindingTRIM37;NDUFS2;PARK2;SMAD7;ERBB2;ACTG1;CD40;CLU;JAK1

RPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPA2.

RPA1; RPA3; SMARCAL1

Machida, T; Kubota, M; et al. Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX). JOURNAL OF TRANSLATIONAL MEDICINE 13:-(2015).
Lee, J; Lee, DH; et al. Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 452:42-47(2014).
  • Q&As
  • Reviews

Q&As (5)

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How might RPA2 be targeted for cancer therapy? 11/12/2022

Targeting RPA2 with specific inhibitors could disrupt DNA repair mechanisms in cancer cells, rendering them more susceptible to treatments like chemotherapy or radiation therapy.

How does RPA2 contribute to the maintenance of telomeres? 05/09/2019

RPA2 participates in the protection and maintenance of telomeres, the protective caps at the end of chromosomes, thereby contributing to cellular longevity and genomic stability.

Are there any known side effects or challenges associated with targeting RPA2 in therapy? 06/16/2018

Targeting RPA2 in therapy may pose challenges, as its essential role in normal cellular processes raises concerns about potential side effects. Careful modulation is crucial.

Can RPA2 be targeted for therapeutic purposes beyond cancer treatment? 08/01/2017

Yes, exploring RPA2 as a therapeutic target extends to conditions where genomic stability is compromised, such as certain genetic disorders and autoimmune diseases.

Are there any ongoing clinical trials involving RPA2 in cancer treatment? 02/13/2016

Information about specific clinical trials should be checked, but the potential use of RPA2 as a target for cancer therapy is an area of active research.

Customer Reviews (3)

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Reviews
12/21/2020

    This commitment ensures that I have access to the most advanced and reliable protein available, enhancing the integrity and impact of my experiments.

    03/30/2020

      The RPA2 protein exhibits exceptional quality, making it an ideal choice to meet my experimental requirements.

      07/19/2018

        the manufacturer's customer-centric approach highlights their focus on ensuring my satisfaction.

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