rpa2
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  • Official Full Name
  • replication protein A2, 32kDa
  • Background
  • Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
  • Synonyms
  • RPA2; replication protein A2, 32kDa; replication protein A2 (32kD); replication protein A 32 kDa subunit; RP-A p32; RP-A p34; RF-A protein 2; replication factor A protein 2; replication protein A 34 kDa subunit; REPA2; RPA32
Cat.#:RPA2-176HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPA2 protein, T7-tagged
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Cat.#:RPA2-2852HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Replication Protein A2, 32kDa, His-tagged
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Cat.#:RPA2-2983HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPA2, T7-tagged
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Cat.#:RPA2-30437THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPA2, T7 -tagged
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Cat.#:RPA2-31146THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPA2, His-tagged
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Cat.#:RPA2-5099RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPA2 Protein
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Cat.#:RPA2-3959RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RPA2 Protein, His-tagged
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Cat.#:RPA2-2581CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPA2
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Cat.#:RPA2-9233ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPA2
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Cat.#:RPA2-2242HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RPA2 293 Cell Lysate
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Involved Pathway

RPA2 involved in several pathways and played different roles in them. We selected most pathways RPA2 participated on our site, such as DNA replication, Nucleotide excision repair, Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA replication
RPA4; MCM6L; RPA2; POLE3; RNASEH2C; MCM6; rnhA; PRIM1; RNASEH2A; MCM2
Nucleotide excision repair
GTF2H1; RFC1; GTF2H5; RFC3; GTF2H2C_2; RAD23B; POLD2; POLE2; GTF2H2C; MCRS1
Mismatch repair
POLD1; RFC2; MLH3; MLH1; RFC1; LIG1; SSBP1; PMS2; RFC3; RFC4
Homologous recombination
RPA2; MRE11A; BRCA2; RPA4; RPA1; RAD51B; NBN; POLD1; FUZ; XRCC2
Fanconi anemia pathway
USP1; POLN; FAN1; POLK; RAD51C; BRCA1; EME2; FUZ; FANCG; PMS2

Protein Function

RPA2 has several biochemical functions, for example, damaged DNA binding, enzyme binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPA2 itself. We selected most functions RPA2 had, and list some proteins which have the same functions with RPA2. You can find most of the proteins on our site.
Function
Related Protein
Function damaged DNA binding
Related Protein POLH; OGG1; DCLRE1C; PCNA; TRP53; EP300; FANCG; POLD1; RAD23A; TP53
Function enzyme binding
Related Protein CCDC99; TRIO; UBE2I; CBS; EIF4E; CYP2A4; GSTM2; KRT79; SELS; SUDS3
Function protein N-terminus binding
Related Protein PEX19; TAF11; TBL1XR1; LACRT; TP53; EIF3E; PDCD10; EXOC4; THAP7; SNCA
Function protein binding
Related Protein CD247; NFKBIB; NUP35; DTNBP1; FASTKD3; PPP2CB; AP1M2; SIGLEC8; C10orf119; STBD1
Function protein phosphatase binding
Related Protein GNB2L1; HSF4; TRAF3; PPME1; JUP; DRD1A; CSF1R; RPA3; FLT4; FGF19
Function single-stranded DNA binding
Related Protein RAD51D; OBFC2B; SSBP3A; HNRNPA1; PURB; CDAN1; TREX1; RBMS1; LUZP4; FBXO18
Function ubiquitin protein ligase binding
Related Protein SUMO2; FZD8; PACRG; SCN5A; RFFL; TMEM189; ASB4; RAD18; RNF40; YOD1

Interacting Protein

RPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPA2.
RPA1; RPA3; SMARCAL1

RPA2 Related Articles

Machida, T; Kubota, M; et al. Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX). JOURNAL OF TRANSLATIONAL MEDICINE 13:-(2015).
Lee, J; Lee, DH; et al. Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 452:42-47(2014).