RPA2
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Official Full Name
replication protein A2, 32kDa
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Overview
Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. -
Synonyms
RPA2; replication protein A2, 32kDa; replication protein A2 (32kD); replication protein A 32 kDa subunit; RP-A p32; RP-A p34; RF-A protein 2; replication factor A protein 2; replication protein A 34 kDa subunit; REPA2; RPA32;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- RPA2 Related Articles
RPA2 involved in several pathways and played different roles in them. We selected most pathways RPA2 participated on our site, such as DNA replication, Nucleotide excision repair, Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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DNA replication | DBF4;RPA1;CDT1;MCM5;LIG1;FEN1;POLD2;POLD4;GINS1 |
Nucleotide excision repair | CUL4B;ERCC1;COPS3;COPS2;COPS6;ERCC3;COPS4;XPC;GTF2H2C |
Mismatch repair | MSH6;MLH1;EXO1;PCNA;POLD4;POLD2;SSBP1;MSH3;RFC3 |
Homologous recombination | TOP3A;RAD51D;POLD4;RAD51;RPA1;BRCA2;RPA2;RAD51L1;CDK5R2 |
Fanconi anemia pathway | RMI2;FANCF;HES1;SLX1B;TOP3A;FUZ;REV1;EME1;RPA1 |
RPA2 has several biochemical functions, for example, damaged DNA binding, enzyme binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPA2 itself. We selected most functions RPA2 had, and list some proteins which have the same functions with RPA2. You can find most of the proteins on our site.
Function | Related Protein |
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damaged DNA binding | RAD23AB;XPC;RAD1;TRP63;NEIL3;RPA2;EP300;FANCG;RAD23AA |
enzyme binding | HINFP;CASP2;SUDS3;HIST1H2AK;TMBIM6;DIS3L;ACAT1;KIAA1967;CDC20 |
protein N-terminus binding | ALG2;RND2;STX5;BIRC2;ATM;HDAC1;YWHAQ;VPS25;SMARCE1 |
protein binding | DUSP23;TCF7L2;RELL2;FKBP1B;ZMAT3;FLNA;LILRB4;C19orf47;COMMD8 |
protein phosphatase binding | KAT2A;STAT3;ANAPC7;PARD3;VCAN;JUPA;MET;PPP1R3C;GNB2L1 |
single-stranded DNA binding | SSBP3;NCL;TDP1;CRY2;SUB1;XRCC3;BRCA2;MCM10;PURB |
ubiquitin protein ligase binding | TRIM37;NDUFS2;PARK2;SMAD7;ERBB2;ACTG1;CD40;CLU;JAK1 |
RPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPA2.
RPA1; RPA3; SMARCAL1
- Q&As
- Reviews
Q&As (5)
Ask a questionTargeting RPA2 with specific inhibitors could disrupt DNA repair mechanisms in cancer cells, rendering them more susceptible to treatments like chemotherapy or radiation therapy.
RPA2 participates in the protection and maintenance of telomeres, the protective caps at the end of chromosomes, thereby contributing to cellular longevity and genomic stability.
Targeting RPA2 in therapy may pose challenges, as its essential role in normal cellular processes raises concerns about potential side effects. Careful modulation is crucial.
Yes, exploring RPA2 as a therapeutic target extends to conditions where genomic stability is compromised, such as certain genetic disorders and autoimmune diseases.
Information about specific clinical trials should be checked, but the potential use of RPA2 as a target for cancer therapy is an area of active research.
Customer Reviews (3)
Write a reviewThis commitment ensures that I have access to the most advanced and reliable protein available, enhancing the integrity and impact of my experiments.
The RPA2 protein exhibits exceptional quality, making it an ideal choice to meet my experimental requirements.
the manufacturer's customer-centric approach highlights their focus on ensuring my satisfaction.
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