RSPO2 Protein, R-spondin 2


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Official Full Name R-spondin 2
Background R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
Synonyms RSPO2; R-spondin 2; CRISTIN2; R-spondin-2; R-spondin 2 homolog; roof plate-specific spondin-2;
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NS0
    • Tag :
    • Fc
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RSPO2-1645HCL Recombinant Human RSPO2 cell lysate Human Cell N/A
    Human RSPO2-171H Recombinant Human RSPO2 Protein CHO N/A
    Human RSPO2-2454H Recombinant Human RSPO2, His-tagged E.coli His
    Human RSPO2-42HCL Recombinant Human RSPO2 HEK293T cell lysate HEK293T Myc/DDK
    Human RSPO2-480H Recombinant Human RSPO2 Protein, Fc-tagged HEK293 Fc
    Human RSPO2-866H Recombinant Human RSPO2 Protein, His-tagged NS0 His
    Mouse RSPO2-14553M Recombinant Mouse RSPO2 Protein Mammalian Cell His
    Mouse Rspo2-850M Recombinant Mouse Rspo2 CHO N/A
    Mouse Rspo2-956M Recombinant Mouse Rspo2 Protein, Fc-tagged HEK293 Fc
    Zebrafish RSPO2-8354Z Recombinant Zebrafish RSPO2 Mammalian Cell His

    RSPO2 involved in several pathways and played different roles in them. We selected most pathways RSPO2 participated on our site, such as Regulation of FZD by ubiquitination, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RSPO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of FZD by ubiquitination LGR6; RSPO4; ZNRF3; RSPO3; FMNL3; LGR4; RSPO2; RNF43; RSPO1; LGR5
    Signal Transduction XK; CRHR2; RNF146; ARHGAP6; CRABP2; ABHD6B; TRIM33; THBS3B; ARHGAP24; CCK
    Signaling by Wnt KREMEN1; HECW1B; WLS; SOX9A; TNKS2; SOX6; RSPO2; FMNL3; GPR177; RBBP5
    TCF dependent signaling in response to WNT TNKS2; RBBP5; HECW1B; RSPO4; KREMEN1; ZNRF3; DACT1; SOX7; SOX4B; SRY

    RSPO2 has several biochemical functions, for example, G-protein coupled receptor binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RSPO2 itself. We selected most functions RSPO2 had, and list some proteins which have the same functions with RSPO2. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor binding SFTPB; ARRB2; GNA11B; S1PR1; RSPO3; S1PR2; GNAT2; GNAI2; USP33; PYY
    heparin binding COMP; CYR61L1; CCL5; RSPO2; VTN; LTBP2; APOB; VEGFB; LPA; GREM2
    protein binding KATNBL1; ZNF496; ADAMTS10; TNFAIP8; GNB2; MTMR4; NGDN; GAD2; ACTB; ANAPC4
    receptor binding CADM2; PTK6B; JAK2; ICOSLG; DAO; PVRL3; POU2F1; TAC4; CXADR; RCHY1

    RSPO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RSPO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RSPO2.

    KRTAP10-4; KRTAP10-7; KRTAP10-9; PLEKHF2; SUV39H1; JMJD6

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