RUNX1 Protein, runt-related transcription factor 1

RUNX1

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RUNX1

Official Full Name runt-related transcription factor 1
Background Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms RUNX1; runt-related transcription factor 1; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; CBF-alpha-2; PEA2-alpha B; PEBP2-alpha B; oncogene AML-1; AML1-EVI-1 fusion protein; acute myeloid leukemia 1 protein; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; core-binding factor, runt domain, alpha subunit 2; polyomavirus enhancer-binding protein 2 alpha B subunit;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Arg
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Runx1-783M Recombinant Mouse Runx1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human RUNX1-148H Recombinant Human RUNX1 protein, Arginine-tagged E.coli Arg
    Human RUNX1-2111HCL Recombinant Human RUNX1 293 Cell Lysate HEK293 N/A
    Human RUNX1-2112HCL Recombinant Human RUNX1 293 Cell Lysate HEK293 N/A
    Human RUNX1-2471H Recombinant Human RUNX1, GST-tagged E.coli GST
    Human RUNX1-263H Recombinant Human RUNX1 Mammalian Cell His
    Human RUNX1-27497TH Recombinant Human RUNX1 Wheat Germ N/A
    Human RUNX1-8209H Recombinant Human RUNX1 protein, His & T7-tagged E.coli His/T7
    Rat RUNX1-5201R Recombinant Rat RUNX1 Protein Mammalian Cell His
    Rhesus Macaque RUNX1-4053R Recombinant Rhesus monkey RUNX1 Protein, His-tagged Mammalian Cell His
    Chicken RUNX1-6780C Recombinant Chicken RUNX1 Mammalian Cell His
    Zebrafish RUNX1-9143Z Recombinant Zebrafish RUNX1 Mammalian Cell His

    RUNX1 involved in several pathways and played different roles in them. We selected most pathways RUNX1 participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Chronic myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer GNB3; MAPK10; CXCL12; MSH3; GNA11; GNGT1; PLD1; MITF; PLCG2; WNT7B
    Transcriptional misregulation in cancer GOLPH3L; HIST1H3I; PBX1; MPO; TLX3; HIST1H3H; IL-8; HIST1H3G; MDM2; DEFA3
    Chronic myeloid leukemia MAP2K1; AKT2; HRAS; CTBP2; BCR; CBLB; NRAS; CBLC; PTPN11; HDAC2
    Acute myeloid leukemia RPS6KB1; RELA; GRB2; PIK3R5; NFKB1; MYC; PIK3R2; PIK3CB; PIM1; SFPI1

    RUNX1 has several biochemical functions, for example, DNA binding, transcription coactivator activity, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX1 itself. We selected most functions RUNX1 had, and list some proteins which have the same functions with RUNX1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding DBX1; HIVEP3; FOXN2B; ZNF559-ZNF177; ARXA; H2AFY; PRM2; ZFP92; TBPL1; MEIS2A
    transcription coactivator activity PRDM16; NACA; BCL10; CREBBP; MED7; GABPA; CITED4; PIAS2; POU2AF1; NR2F1
    transcription factor activity, sequence-specific DNA binding STAT5B; TAF13; RXRGA; POU5F1; TADA2B; FOXD1; FOXI3A; TAF6; ZNF167; HOXD10
    zinc ion binding NR1D4B; WT1; MLL5; GFI1; CUL9; RBM4.2; RNF152; MT1B; CSRP1B; ZFAND1

    RUNX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX1.

    CDK6; HIPK2; NCOR2; CBFB; ELF2; WWTR1; TAL1

    Lindskog, C; Kuhlwilm, M; et al. Analysis of Candidate Genes for Lineage-Specific Expression Changes in Humans and Primates. JOURNAL OF PROTEOME RESEARCH 13:3596-3606(2014).
    Ren, TL; Han, ZJ; et al. Association of SLC22A4 Gene Polymorphism with Rheumatoid Arthritis in the Chinese Population. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 28:206-210(2014).

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