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RYK

  • Official Full Name

    receptor-like tyrosine kinase

  • Overview

    The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.
  • Synonyms

    RYK; receptor-like tyrosine kinase; JTK5A, JTK5A protein tyrosine kinase , RYK receptor like tyrosine kinase; tyrosine-protein kinase RYK; D3S3195; JTK5; RYK1; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; RYK receptor-like tyrosine kinase;

  • Recombinant Proteins
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK|His
  • Fc Chimera
  • GST
  • hFc
  • His
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RYK-633H Active Recombinant Human RYK, Fc Chimera CHO Fc Chimera
Human RYK-262H Recombinant Human RYK, GST-tagged Sf9 Insect Cell GST
Human RYK-31340TH Recombinant Human RYK Wheat Germ N/A 110 amino acids
Human RYK-694H Recombinant Human RYK Protein, DDK/His-tagged HEK293 DDK/His
Human RYK-1937H Recombinant Human RYK protein, His & T7-tagged E.coli His/T7 Lys308~Cys570 (Accession # NM_001005861.2)
Human RYK-2012H Recombinant Human RYK Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RYK-3895H Recombinant Human RYK protein, His-tagged E.coli His 261-610 aa
Human RYK-634H Recombinant Human RYK protein, hFc-tagged HEK293 hFc Met1-Arg227
Human RYK-6209H Recombinant Human RYK Protein (Leu308-Pro568), N-His tagged E.coli N-His Leu308-Pro568
Mouse Ryk-1938M Recombinant Mouse Ryk protein, His & T7-tagged E.coli His/T7 Thr287~Ile533 (Accession # Q01887)
Mouse Ryk-5663M Recombinant Mouse Ryk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Homo sapiens (Human) RFL18925HF Recombinant Full Length Human Tyrosine-Protein Kinase Ryk(Ryk) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-607)
Zebrafish RYK-5445Z Recombinant Zebrafish RYK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RYK Related Articles
  • RYK Related Research Area

RYK involved in several pathways and played different roles in them. We selected most pathways RYK participated on our site, such as Beta-catenin independent WNT signaling, PCP/CE pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Beta-catenin independent WNT signalingPRICKLE1;AGO2;DVL3;AP2B1;PRICKLE1B;CLTC;ROR1;DVL1;AGO1
PCP/CE pathwayPRICKLE1;ROR2;ROR1;PRICKLE1B;RYK
Signal TransductionCHN1;GHRB;TAGAP1;CRABP1B;NPS;MKL1;CCK;TJP2B;RHOJ
Signaling by WntSOX4A;KLHL12;RSPO1;ASH2L;AES;PYGO2;BCL9;WLS;SOX9A
TCF dependent signaling in response to WNTC;CCDC88C;TNKS2;SOX6;BCL9;RNF146;SOX7;SOX4B;BCL9L
Wnt signaling networkRYK;CTHRC1;WIF1;RSPO1;IGFBP4;ATP6AP2

RYK has several biochemical functions, for example, ATP binding, protein binding, NOT protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RYK itself. We selected most functions RYK had, and list some proteins which have the same functions with RYK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPI4K2B;NEK2;HSPA1B;YME1L1B;CKMB;KIF16B;PLK1;MCM7;SLFNL1
protein bindingLTBP2;CARTPT;HEMK1;CNTNAP4;KRT15;PLXNB2;ERBB2;CCNB3;CLK1
NOT protein tyrosine kinase activityERBB3;TWF1;RYK;KLHL8
transmembrane receptor protein tyrosine kinase activityEGFR;EPHB4B;RYK;PDGFRA;FGFR1A;FLT3;DDR1;ROR1;ERBB3A
transmembrane signaling receptor activityNRXN2;OR2A4;FZD7A;CD3E;IL4R.1;LAG3;CD300C;CD3G;TLR5

RYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYK here. Most of them are supplied by our site. Hope this information will be useful for your research of RYK.

CFTR

Cummings, CT; DeRyckere, D; et al. Molecular Pathways: MERTK Signaling in Cancer. CLINICAL CANCER RESEARCH 19:5275-5280(2013).
Halford, MM; Macheda, ML; et al. A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK. PLOS ONE 8:-(2013).
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