ryk
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  • Official Full Name
  • receptor-like tyrosine kinase
  • Background
  • The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.
  • Synonyms
  • RYK; receptor-like tyrosine kinase; JTK5A, JTK5A protein tyrosine kinase , RYK receptor like tyrosine kinase; tyrosine-protein kinase RYK; D3S3195; JTK5; RYK1; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; RYK receptor-like tyrosine kinase
Cat.#:RYK-2012HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RYK Protein, MYC/DDK-tagged
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Cat.#:RYK-1937HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RYK protein, His & T7-tagged
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Cat.#:RYK-262HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RYK, GST-tagged
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Cat.#:RYK-31340THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RYK
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Cat.#:RYK-633HTag:Fc Chimera
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human RYK, Fc Chimera
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Cat.#:RYK-694HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human RYK Protein, DDK/His-tagged
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Cat.#:Ryk-1938MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ryk protein, His & T7-tagged
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Cat.#:RYK-5445ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RYK
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Involved Pathway

RYK involved in several pathways and played different roles in them. We selected most pathways RYK participated on our site, such as Beta-catenin independent WNT signaling, PCP/CE pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYK were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Beta-catenin independent WNT signaling
AGO2; AP2A1; GNB5; ROR1; PRICKLE1; AP2M1; CLTC; ROR2; ITPR2; DVL3
PCP/CE pathway
RYK; ROR1; ROR2; PRICKLE1; PRICKLE1B
Signal Transduction
WNT8-2; GPR65; OR10A5; OTULIN; TLE2; AXL; NMBA; KLHL12; STARD8; METAP2
Signaling by Wnt
AES; C; WIF1; FMNL3; SOX7; RNF146; KREMEN2; SOX9A; WNT8-2; KREMEN1
TCF dependent signaling in response to WNT
ASH2L; TNKS2; RNF146; KREMEN1; RSPO4; RSPO1; LGR5; RSPO3; HECW1; C
Wnt signaling network
RYK; WIF1; IGFBP4; CTHRC1; ATP6AP2; RSPO1

Protein Function

RYK has several biochemical functions, for example, ATP binding, protein binding, NOT protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RYK itself. We selected most functions RYK had, and list some proteins which have the same functions with RYK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAPK8B; MYH9; ERBB3B; KIF4; STK38L; CHD1; ABCC8; TRIOA; NAT10; KDR
Function protein binding
Related Protein AMOTL2A; L3MBTL4; TP73; ARL6IP5; C1orf216; PVRL4; MECP2; STK24; PRKAR1A; MKI67IP
Function NOT protein tyrosine kinase activity
Related Protein ERBB3; KLHL8; TWF1; RYK
Function transmembrane receptor protein tyrosine kinase activity
Related Protein TRIM27; IGF1RB; ERBB3B; NTRK3A; MERTK; EPHB2B; AXL; DDR1; NPTN; TEK
Function transmembrane signaling receptor activity
Related Protein KLRF1; CD69; LGR6; OR115-6; LILRB3; CLDN3; GHRHRL; HIST2H3C2; OR6K3; NRXN2

Interacting Protein

RYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYK here. Most of them are supplied by our site. Hope this information will be useful for your research of RYK.
CFTR

RYK Related Articles

Cummings, CT; DeRyckere, D; et al. Molecular Pathways: MERTK Signaling in Cancer. CLINICAL CANCER RESEARCH 19:5275-5280(2013).
Halford, MM; Macheda, ML; et al. A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK. PLOS ONE 8:-(2013).